... by altering their proteome to survive. However, in many neurodegenerative disorders, such as Parkinson's disease, the pathway and processes for coping with cellular stress are impaired. This review explores neuronal proteome adaptation in response to cellular stress, such as nutrient stress, with a focus...

... such as native MS, top-down proteomics, and ion mobility MS. Other MS-based structural methods include affinity purification MS, chemical cross-linking, and protein footprinting. These methods have enabled the study of protein–protein and protein–ligand interactions and regions of conformational change...

... The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . enzyme mechanism of action microRNA MSC exosome proteome In contrast with large...

... novel ones, as mentioned before. However, many non-coding RNAs and the smORFs they contain remain controversial. long non-coding ribonucleic acid (ncRNA) NGS sequencing of footprints from polysome fractions (Poly-Ribo-Seq) proteome ribosome profiling small open reading frames (smORFs...

... that if we want to obtain a collection of structurally and functionally meaningful TRs from a large scale analysis of proteomes, the TR scoring metrics need to be improved. It is difficult to find a clear criterion for true and false TRs within unstructured regions and, as a result, this complicates...

...Carmelina Petrungaro; Jan Riemer Eukaryotic cells developed diverse mechanisms to guide proteins to more than one destination within the cell. Recently, the proteome of the IMS (intermembrane space) of mitochondria of yeast cells was identified showing that approximately 20% of all soluble IMS...

..., there is the common technique of real-time RT (reverse transcription)–PCR and direct quantification of mRNA copy number by the Nanostring™ method. For glyoxalase protein quantification, there is the commonly used Western blotting, and also immunoassay and, in proteome-wide studies, quantitative proteomics...

...S.G.N. Grant Synapse proteomics has recently resulted in a quantum leap in knowledge of the protein composition of brain synapses and its phosphorylation. We now have the first draft picture of the synapse, comprising ∼1000 proteins. This is not matched by available methods of functional analysis...

... Nature's Networks a Biochemical Society Focused Meeting held at University of Sheffield, 21 July 2003 22 July 2003 © 2003 Biochemical Society 2003 network interactome power law proteome scale free yeast two-hybrid Unravelling Nature s Networks 1491 On the structure...