... and restore proteostasis, which is the focus of this review. Significantly, disruptions in protein homeostasis link strongly to the pathology of several degenerative disorders highly relevant in ageing societies. A comprehensive understanding of protein import quality control will allow harnessing...

...Kathrin Ulrich Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as a first line...

...Tahir Muhammad; Jian Li Protein homeostasis (proteostasis) is essential for cellular function and organismal health and requires the concerted actions of protein synthesis, folding, transport, and turnover. In sexually reproducing organisms, the immortal germline lineage passes genetic information...

...Noah S. Helton; Stephanie L. Moon Maintenance of proteostasis is of utmost importance to cellular viability and relies on the coordination of many post-transcriptional processes to respond to stressful stimuli. Stress granules (SGs) are RNA–protein condensates that form after translation initiation...

...Sarah Rolli; Emily Mitchell Sontag Properly folded, functional proteins are essential for cell health. Cells sustain protein homeostasis, or proteostasis, via protein quality control (PQC) mechanisms. It is currently hypothesized that a breakdown in proteostasis during ageing leads...

... The Author(s) 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene regulation growth proteostasis ribosome biogenesis Saccharomyces cerevisiae yeast...

... might regulate ER proteostasis and the implication thereof to general cell physiology. Correspondence: Hesso Farhan ( [email protected] ) 19 12 2019 22 1 2020 27 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society...

... fragments to lysosomal compartments for clearance. It gives essential contribution to the maintenance of cellular homeostasis, proteostasis, lipidostasis and oligosaccharidostasis (i.e. the capacity to produce the proteome, lipidome and oligosaccharidome in appropriate quality and quantity). ER turnover...

... that glycated proteins, some of which are toxic and reduce cell homoeostasis, induce ER dysfunction (ER stress) associated with the pathogenic UPR state. These pieces of evidence significantly highlight the close link between glycative stress and ER stress, namely ER proteostasis [ 3 ]. We reported...