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Keywords: proteostasis
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Biochem Soc Trans (2023) 51 (6): 2117–2126.
Published: 21 November 2023
... and restore proteostasis, which is the focus of this review. Significantly, disruptions in protein homeostasis link strongly to the pathology of several degenerative disorders highly relevant in ageing societies. A comprehensive understanding of protein import quality control will allow harnessing...
Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
...Kathrin Ulrich Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as a first line...
Biochem Soc Trans (2023) 51 (2): 501–512.
Published: 09 March 2023
...Tahir Muhammad; Jian Li Protein homeostasis (proteostasis) is essential for cellular function and organismal health and requires the concerted actions of protein synthesis, folding, transport, and turnover. In sexually reproducing organisms, the immortal germline lineage passes genetic information...
Biochem Soc Trans (2022) 50 (6): 1715–1724.
Published: 09 December 2022
...Noah S. Helton; Stephanie L. Moon Maintenance of proteostasis is of utmost importance to cellular viability and relies on the coordination of many post-transcriptional processes to respond to stressful stimuli. Stress granules (SGs) are RNA–protein condensates that form after translation initiation...
Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
...Sarah Rolli; Emily Mitchell Sontag Properly folded, functional proteins are essential for cell health. Cells sustain protein homeostasis, or proteostasis, via protein quality control (PQC) mechanisms. It is currently hypothesized that a breakdown in proteostasis during ageing leads...
Biochem Soc Trans (2021) 49 (4): 1589–1599.
Published: 09 July 2021
... The Author(s) 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene regulation growth proteostasis ribosome biogenesis Saccharomyces cerevisiae yeast...
Biochem Soc Trans (2020) 48 (1): 199–205.
Published: 17 February 2020
... might regulate ER proteostasis and the implication thereof to general cell physiology. Correspondence: Hesso Farhan ( hesso.farhan@medisin.uio.no ) 19 12 2019 22 1 2020 27 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society...
Biochem Soc Trans (2018) 46 (3): 699–706.
Published: 25 May 2018
... fragments to lysosomal compartments for clearance. It gives essential contribution to the maintenance of cellular homeostasis, proteostasis, lipidostasis and oligosaccharidostasis (i.e. the capacity to produce the proteome, lipidome and oligosaccharidome in appropriate quality and quantity). ER turnover...
Biochem Soc Trans (2014) 42 (2): 457–460.
Published: 20 March 2014
... and UPR (unfolded protein response), which controls the protein homoeostasis state. chronic kidney disease (CKD) endoplasmic reticulum stress (ER stress) glycation hypoxia proteostasis unfolded protein response (UPR) 1 email inagi-npr@umin.ac.jp 6 1 2013 ©...