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1-9 of 9
Keywords: proteostasis
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Articles
Mechanisms of stress management in mitochondrial protein import
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2117–2126.
Published: 21 November 2023
... and restore proteostasis, which is the focus of this review. Significantly, disruptions in protein homeostasis link strongly to the pathology of several degenerative disorders highly relevant in ageing societies. A comprehensive understanding of protein import quality control will allow harnessing...
Articles
Redox-regulated chaperones in cell stress responses
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
...Kathrin Ulrich Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as a first line...
Articles
Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 501–512.
Published: 09 March 2023
...Tahir Muhammad; Jian Li Protein homeostasis (proteostasis) is essential for cellular function and organismal health and requires the concerted actions of protein synthesis, folding, transport, and turnover. In sexually reproducing organisms, the immortal germline lineage passes genetic information...
Articles
Is bRaQCing bad? New roles for ribosome associated quality control factors in stress granule regulation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1715–1724.
Published: 09 December 2022
...Noah S. Helton; Stephanie L. Moon Maintenance of proteostasis is of utmost importance to cellular viability and relies on the coordination of many post-transcriptional processes to respond to stressful stimuli. Stress granules (SGs) are RNA–protein condensates that form after translation initiation...
Articles
Spatial sequestration of misfolded proteins in neurodegenerative diseases
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
...Sarah Rolli; Emily Mitchell Sontag Properly folded, functional proteins are essential for cell health. Cells sustain protein homeostasis, or proteostasis, via protein quality control (PQC) mechanisms. It is currently hypothesized that a breakdown in proteostasis during ageing leads...
Articles
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1589–1599.
Published: 09 July 2021
... The Author(s) 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene regulation growth proteostasis ribosome biogenesis Saccharomyces cerevisiae yeast...
Articles
Tyrosine kinase signaling in and on the endoplasmic reticulum
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 199–205.
Published: 17 February 2020
... might regulate ER proteostasis and the implication thereof to general cell physiology. Correspondence: Hesso Farhan ( [email protected] ) 19 12 2019 22 1 2020 27 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society...
Articles
Eat it right: ER-phagy and recovER-phagy
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (3): 699–706.
Published: 25 May 2018
... fragments to lysosomal compartments for clearance. It gives essential contribution to the maintenance of cellular homeostasis, proteostasis, lipidostasis and oligosaccharidostasis (i.e. the capacity to produce the proteome, lipidome and oligosaccharidome in appropriate quality and quantity). ER turnover...
Articles
Glycative stress and glyoxalase in kidney disease and aging
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 457–460.
Published: 20 March 2014
... that glycated proteins, some of which are toxic and reduce cell homoeostasis, induce ER dysfunction (ER stress) associated with the pathogenic UPR state. These pieces of evidence significantly highlight the close link between glycative stress and ER stress, namely ER proteostasis [ 3 ]. We reported...