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Keywords: pseudokinase
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Articles
Biochem Soc Trans (2018) 46 (6): 1713–1720.
Published: 04 December 2018
... and let die: insights into pseudoenzyme mechanisms from structure . Curr. Opin. Struct. Biol. 47 , 95 – 104 10.1016/j.sbi.2017.07.004 5 Reiterer , V. , Eyers , P.A. and Farhan , H. ( 2014 ) Day of the dead: pseudokinases and pseudophosphatases in physiology and disease...
Articles
Biochem Soc Trans (2017) 45 (2): 537–544.
Published: 13 April 2017
... 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 enzyme non-catalytic pseudoenzyme pseudokinase pseudophosphatase The existence of pseudoenzymes was first inferred through a direct comparison of the sequences of lysozyme and α...
Articles
Biochem Soc Trans (2015) 43 (5): 1095–1103.
Published: 09 October 2015
...Daniel M. Foulkes; Dominic P. Byrne; Fiona P. Bailey; Patrick A. Eyers Tribbles (TRIB) proteins are pseudokinase mediators of eukaryotic signalling that have evolved important roles in lipoprotein metabolism, immune function and cellular differentiation and proliferation. In addition...
Articles
Biochem Soc Trans (2013) 41 (4): 995–1001.
Published: 18 July 2013
... structural consequences [ 10 , 26 , 27 ]. The final strong evidence that ILK is a bona fide pseudokinase comes from the crystal structure of ILK-KD in complex with the CH2 domain of α-parvin at 1.8 Å resolution [ 13 ]. The structure reveals that, even though the ILK KD possesses the characteristic...
Articles
Biochem Soc Trans (2013) 41 (4): 1029–1036.
Published: 18 July 2013
...Jeannine M. Mendrola; Fumin Shi; Jin H. Park; Mark A. Lemmon As with other groups of protein kinases, approximately 10% of the RTKs (receptor tyrosine kinases) in the human proteome contain intracellular pseudokinases that lack one or more conserved catalytically important residues. These include...
Articles
Biochem Soc Trans (2013) 41 (4): 969–974.
Published: 18 July 2013
...Patrick A. Eyers; James M. Murphy Recent studies of proteins containing kinase-like domains that lack catalytic residue(s) classically required for phosphotransfer, termed pseudokinases, have uncovered important roles in cell signalling across the kingdoms of life. Additionally, mutations within...
Articles
Biochem Soc Trans (2013) 41 (4): 1002–1007.
Published: 18 July 2013
...Olli Silvennoinen; Daniela Ungureanu; Yashavanthi Niranjan; Henrik Hammaren; Rajintha Bandaranayake; Stevan R. Hubbard JAK (Janus kinase) 2 plays a critical role in signal transduction through several cytokine receptors. JAKs contain a typical tyrosine kinase domain preceded by a pseudokinase [JH2...
Articles
Biochem Soc Trans (2013) 41 (4): 975–980.
Published: 18 July 2013
...Isabelle S. Lucet; Jeffrey J. Babon; James M. Murphy Approximately 10% of the human kinome has been classified as pseudokinases due to the absence of one or more of three motifs known to play key roles in the catalytic activities of protein kinases. Structural and functional studies are now...
Articles
Biochem Soc Trans (2013) 41 (4): 981–986.
Published: 18 July 2013
... by the adenine ring of ATP. In the present paper, we show how the spine concept can be applied to B-Raf, specifically to engineer a kinase-dead pseudokinase. To achieve this, we mutated one of the C-spine residues in the N-lobe (N-terminal lobe), Ala 481 , to phenylalanine. This mutant cannot bind ATP...
Articles
Biochem Soc Trans (2013) 41 (4): 1078–1082.
Published: 18 July 2013
...Hua Zhang; Chuay Yeng Koo; Justin Stebbing; Georgios Giamas Protein kinases play a pivotal role in regulating many aspects of biological processes, including development, differentiation and cell death. Within the kinome, 48 kinases (~10%) are classified as pseudokinases owing to the fact...
Articles
Biochem Soc Trans (2013) 41 (4): 1083–1088.
Published: 18 July 2013
...Jeroen Claus; Angus J.M. Cameron; Peter J. Parker Pseudokinases, the catalytically impaired component of the kinome, have recently been found to share more properties with active kinases than previously thought. In many pseudokinases, ATP binding and even some activity is preserved, highlighting...
Articles
Biochem Soc Trans (2013) 41 (4): 1055–1060.
Published: 18 July 2013
...Jason S. Kerr; Catherine H. Wilson Pseudokinases are a class of kinases which are structurally designated as lacking kinase activity. Despite the lack of kinase domain sequence conservation, there is increasing evidence that a number of pseudokinases retain kinase activity and/or have critical...