... combining structural, biochemical, and functional approaches revealed that these pseudokinases have crucial roles in vivo and may even represent attractive targets for pharmacological intervention. Pseudokinases mediate signal transduction by a diversity of mechanisms, including allosteric regulation...

... protein kinases are, however, thought to be catalytically inactive. These kinases lack conserved residues of the kinase core and are classified as pseudokinases. Yet, it has been demonstrated that pseudokinases are critically involved in biological functions. Here, we show how pseudokinases have developed...

...Annette V. Jacobsen; James M. Murphy Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise ∼10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies...

... ( [email protected] ) 9 1 2017 16 2 2017 17 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 gear-shifting bioenergetics origin of life protein modularity pseudokinases pseudosignalers systems biology...