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Keywords: reactive oxygen species (ROS)
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Biochem Soc Trans (2015) 43 (4): 680–686.
Published: 03 August 2015
... such as reactive oxygen species (ROS) and electrophilic xenobiotics, effectively providing a cellular survival mechanism. This cytoprotective activity of Nrf2 has been implicated in disease prevention, including cancer [ 5 – 8 ]. In the case of cancer, controlled Nrf2 up-regulation has shown to protect against...
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Biochem Soc Trans (2014) 42 (4): 959–964.
Published: 11 August 2014
... oxygen species (ROS) redox imaging RTT (Rett syndrome) was initially described in 1966 as an “unusual brain atrophy syndrome” [ 1 , 2 ]. It primarily affects girls with a prevalence of 1:10000–15000, and is associated with severe cognitive impairment. Typically, RTT progresses in four stages...
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Biochem Soc Trans (2014) 42 (4): 922–927.
Published: 11 August 2014
... for lifespan and immune function. ageing oxidation reactive oxygen species (ROS) rheumatoid arthritis thiol thioredoxin Trx (thioredoxin) was first identified in Escherichia coli in 1964 as an essential cofactor (hydrogen donor) for ribonucleotide reductase [ 1 ]. Trx is a small (12 kDa...
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Biochem Soc Trans (2014) 42 (4): 934–938.
Published: 11 August 2014
... correspondence should be addressed (email t.cotter@ucc.ie ). 31 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer hydrogen peroxide (H 2 O 2 ) NADPH oxidase (Nox) reactive oxygen species (ROS) signalling It comes as no surprise that such spatially...
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Biochem Soc Trans (2014) 42 (2): 370–376.
Published: 20 March 2014
... cell death (PCD) reactive oxygen species (ROS) self-incompatibility Successful sexual reproduction in many flowering plants involves a genetically controlled mechanism called SI (self-incompatibility). SI is genetically controlled by a multi-allelic S -locus that encodes linked pollen...
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Biochem Soc Trans (2014) 42 (1): 1–10.
Published: 23 January 2014
... be addressed (email areddy@cantab.net ). 14 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 circadian rhythm peroxiredoxin reactive oxygen species (ROS) redox homoeostasis Circadian rhythms are arguably one of life's most basic mechanisms, regulating...
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Biochem Soc Trans (2012) 40 (4): 735–738.
Published: 20 July 2012
... cleavage Creutzfeldt–Jakob disease octapeptide repeat prion processing reactive oxygen species (ROS) ADAM a disintegrin and metalloproteinase CDP chronic demyelinating polyneuropathy CJD Creutzfeldt–Jakob disease OR octapeptide repeat PrP prion protein PrP C...
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Biochem Soc Trans (2012) 40 (1): 129–132.
Published: 19 January 2012
... caldesmon, which was described previously as a negative regulator of podosomes and invadopodia. Thus Cdk5 represents a validated invadopodia target. atherosclerosis cancer embryonic development reactive oxygen species (ROS) Podosomes and invadopodia can be defined as dynamic actin-rich...
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Biochem Soc Trans (2011) 39 (6): 1715–1718.
Published: 21 November 2011
... email c.j.hutchison@durham.ac.uk 5 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA damage response Hutchinson–Gilford progeria syndrome (HGPS) lamin laminopathy progeria reactive oxygen species (ROS) As stated above, the most obvious...
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Biochem Soc Trans (2011) 39 (6): 1683–1686.
Published: 21 November 2011
... organization Emery–Dreifuss muscular dystrophy (EDMD) Hutchinson–Gilford progeria syndrome (HGPS) induced pluripotent stem cell (iPSC) nuclear envelope disease reactive oxygen species (ROS) © The Authors Journal compilation © 2011 Biochemical Society 2011 14 9 2011 Lamin...
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Biochem Soc Trans (2011) 39 (5): 1544–1548.
Published: 21 September 2011
... endoplasmic reticulum farnesol reactive oxygen species (ROS) FOH (farnesol), a non-sterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, has been shown to inhibit proliferation and induce apoptosis in neoplastic cell lines and also to be effective in chemoprevention...
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Biochem Soc Trans (2011) 39 (5): 1471–1475.
Published: 21 September 2011
... signalling quorum sensing reactive oxygen species (ROS) stress defence and dying yeast colony architecture and differentiation Most knowledge of yeast cell reproduction, aging and dying comes from laboratory investigations, where cells are often treated in liquid cultures grown under various...
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Biochem Soc Trans (2011) 39 (5): 1273–1278.
Published: 21 September 2011
... inflammation reactive oxygen species (ROS) redox signalling regulatory T-cell (T reg cell) The principal function of the immune system is to discriminate between self and non-self, and the effector T-cell arm (including TH1, TH2 and TH17; see Figure 1 ) is responsible, along with the B-cell arm...
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Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... mitochondrion programmed cell death (PCD) reactive oxygen species (ROS) Saccharomyces cerevisiae YCA1 The term PCD (programmed cell death) describes a highly heterogeneous process regulated by distinct but sometimes overlapping pathways including apoptosis, autophagic cell death, and necrosis...
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Biochem Soc Trans (2011) 39 (5): 1221–1225.
Published: 21 September 2011
... and HPLC to detect and quantify O 2 •− formed in cells and tissues [ 4 , 5 ]. cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide © The Authors Journal compilation © 2011 Biochemical Society 2011 15 7...
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Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
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Biochem Soc Trans (2008) 36 (5): 930–934.
Published: 19 September 2008
... ). 8 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes lipotoxicity mitochondrial DNA (mtDNA) oxidative stress pancreatic β-cell reactive oxygen species (ROS) Pancreatic β-cells are poised to sense glucose and other nutrient secretagogues...
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Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
... mitochondrion NADH:ubiquinone oxidoreductase oxidative stress reactive oxygen species (ROS) reverse electron transport The electron transport chain in mitochondria is a significant source of cellular ROS. Historically, respiratory complexes I and III have been considered two major sources...
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Biochem Soc Trans (2007) 35 (1): 28–32.
Published: 22 January 2007
.... 1 email schuber1@life.uiuc.edu 31 8 2006 © 2007 The Biochemical Society 2007 nitrate plant metabolism protein phosphorylation photosynthesis reactive oxygen species (ROS) sucrose phosphate synthase (SPS) This review focuses on phosphorylation and signalling...
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Biochem Soc Trans (2005) 33 (6): 1394–1396.
Published: 26 October 2005
... 1 To whom correspondence should be addressed (email vb207@mole.bio.cam.ac.uk ). 4 7 2005 © 2005 The Biochemical Society 2005 apoptosis hypoxia necrosis nitric oxide (NO) reactive oxygen species (ROS) superoxide production NO is an important regulator of cell...
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Biochem Soc Trans (2005) 33 (6): 1385–1389.
Published: 26 October 2005
...) lysophosphatidylcholine mitochondrion oxidized lipid reactive oxygen species (ROS) thiol The formation of low molecular mass second messengers as cell-signalling molecules is well established in the redox cell-signalling field. The molecules involved in signalling are structurally diverse and include the ROS...
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Biochem Soc Trans (2005) 33 (2): 375–379.
Published: 01 April 2005
... reactive oxygen species (ROS) upstream sensing upstream signalling Abiotic stress can limit crop productivity and is a key determinant of the natural distribution of plant species. Abiotic stresses, such as low water potential and salt stress, that cause water loss or reduced water uptake also lead...
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Biochem Soc Trans (2004) 32 (6): 1070–1071.
Published: 26 October 2004
... Society 2004 elimination of mitochondria fission fusion mitochondrial inhibitors reactive oxygen species (ROS) When HeLa cells were treated for 48–72 h with uncouplers in combination with antimycine or myxothiazole, a significant (50–70%) fraction of the cells died but the rest...
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Biochem Soc Trans (2004) 32 (6): 1018–1020.
Published: 26 October 2004
... 2004 hydrogen peroxide phosphatase protein tyrosine phosphatase (PTP) reactive oxygen species (ROS) redox signalling superoxide Regulated reversible phosphorylation of proteins and other cellular molecules plays a ubiquitous role in the control of cellular behaviour. Several different...
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Biochem Soc Trans (2003) 31 (6): 1441–1444.
Published: 01 December 2003
... of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 9 July 2003 © 2003 Biochemical Society 2003 apoptosis growth factor Mn superoxide dismutase Ras reactive oxygen species (ROS) senescence Abbreviations used: AP-1, activator protein-1; DPI...