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Keywords: redox signalling
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Biochem Soc Trans (2024) 52 (1): 269–278.
Published: 19 February 2024
... hundreds of target genes [ 17 ], including antioxidant enzymes such as NAD(P)H:quinone oxidoreductase-1 (NQO1), heme oxygenase-1 (HO-1) and glutamate cysteine ligase (GCL) [ 18–20 ] but also regulators of protein clearance and metabolism [ 13 , 21–23 ]. Metals have been linked with redox signalling due...
Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
... chaperones oxidative stress protein aggregation proteostasis redox signalling Molecular chaperones are highly conserved proteins that assist polypeptides in acquiring or retaining their native, functional conformation. Client recognition and binding are typically based on a combination...
Biochem Soc Trans (2020) 48 (3): 745–754.
Published: 15 May 2020
... for facilitated or directed oxidation of specific targets. These findings help define conditions that enable redox signalling but there is still much to learn regarding mechanisms. Correspondence: Christine C. Winterbourn ( christine.winterbourn@otago.ac.nz ) 8 3 2020 14 4 2020 16 4 2020...
Biochem Soc Trans (2020) 48 (2): 379–397.
Published: 20 April 2020
... there is a causal relation between the two. This review describes how protein aggregation can be affected both by redox signalling (downstream of H 2 O 2 ), as well as by ROS-induced damage, and aims to give an overview of the current knowledge of how redox signalling affects protein aggregation and vice versa...
Biochem Soc Trans (2020) 48 (2): 613–620.
Published: 27 March 2020
... acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail...
Biochem Soc Trans (2020) 48 (2): 367–377.
Published: 20 March 2020
... of ROS may actually be beneficial as mediators of redox signalling. In this context, enhancing ROS production in model organisms can extend lifespan, with biological effects dependent on the site, levels, and specific species of ROS. In this review, we examine the role of ROS in ageing, with a particular...
Biochem Soc Trans (2014) 42 (4): 971–978.
Published: 11 August 2014
... response. This phenomenon of signalling through cysteine oxidation is known as redox signalling and has recently been shown to be involved in a wide range of physiological processes. Cysteine residue oxidation can lead to a range of post-translational modifications, one of which is the formation...
Biochem Soc Trans (2013) 41 (1): 118–123.
Published: 29 January 2013
...Sergey Zharikov; Sruti Shiva Circulating blood platelets contain small numbers of fully functional mitochondria. Accumulating evidence demonstrates that these mitochondria regulate the pro-thrombotic function of platelets through not only energy generation, but also redox signalling...
Biochem Soc Trans (2011) 39 (5): 1247–1253.
Published: 21 September 2011
...Claus Jacob Research conducted during the last two decades has provided evidence for the existence of an extensive intracellular redox signalling, control and feedback network based on different cysteine-containing proteins and enzymes. Together, these proteins enable the living cell to sense...
Biochem Soc Trans (2006) 34 (5): 960–964.
Published: 25 October 2006
... in redox signalling. Seven NADPH oxidase isoforms, known as Noxs ( N APDH ox idases), are expressed in a cell- and tissue-specific fashion. These oxidases are thought to subserve distinct functions as a result of their tightly regulated activation (e.g. by neurohormonal and growth factors and mechanical...
Biochem Soc Trans (2004) 32 (6): 1018–1020.
Published: 26 October 2004
... studies should give us a clearer picture of the role of phosphatase inactivation in cellular behaviour and explain how specificity is achieved in redox signalling. 1 To whom correspondence should be addressed (email n.r.leslie@dundee.ac.uk ). 8 7 2004 © 2004 The Biochemical Society...
Biochem Soc Trans (2003) 31 (6): 1295–1299.
Published: 01 December 2003
... 1 July 2003 © 2003 Biochemical Society 2003 antioxidant lipophilic cation mitochondria oxidative stress reactive oxygen species redox signalling Abbreviations used: Δμ H + , proton electrochemical potential gradient; ΔpH, pH gradient; Δψ, membrane potential; Δψ m...