... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . KEAP1 NRF2 oxygen redox signalling zinc Oxidative stress is increasingly recognised as a contributor to redox dysregulation in various diseases such as stroke, cardiovascular diseases, diabetes and cancer [ 1–6...

... regions and their connectivity in the inactivation of a redox-regulated chaperone and its inter-chaperone crosstalk . Antioxid. Redox Signal. 27 , 1252 – 1267 10.1089/ars.2016.6900 22 Dahl , J.U. , Gray , M.J. and Jakob , U. ( 2015 ) Protein quality control under oxidative...

... for facilitated or directed oxidation of specific targets. These findings help define conditions that enable redox signalling but there is still much to learn regarding mechanisms. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 hydrogen peroxide...

... there is a causal relation between the two. This review describes how protein aggregation can be affected both by redox signalling (downstream of H 2 O 2 ), as well as by ROS-induced damage, and aims to give an overview of the current knowledge of how redox signalling affects protein aggregation and vice versa...

... acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail...

... of ROS may actually be beneficial as mediators of redox signalling. In this context, enhancing ROS production in model organisms can extend lifespan, with biological effects dependent on the site, levels, and specific species of ROS. In this review, we examine the role of ROS in ageing, with a particular...

... response. This phenomenon of signalling through cysteine oxidation is known as redox signalling and has recently been shown to be involved in a wide range of physiological processes. Cysteine residue oxidation can lead to a range of post-translational modifications, one of which is the formation...

...Sergey Zharikov; Sruti Shiva Circulating blood platelets contain small numbers of fully functional mitochondria. Accumulating evidence demonstrates that these mitochondria regulate the pro-thrombotic function of platelets through not only energy generation, but also redox signalling...

...Claus Jacob Research conducted during the last two decades has provided evidence for the existence of an extensive intracellular redox signalling, control and feedback network based on different cysteine-containing proteins and enzymes. Together, these proteins enable the living cell to sense...

... ). 2 Present address: Birmingham Dental School, St Chad's Queensway, Birmingham B4 6NN, U.K. 3 Present address: Abbott Laboratories, Abbott Park, IL 60064, U.S.A. 18 7 2011 ageing glutathione inflammation reactive oxygen species (ROS) redox signalling regulatory T...

... in redox signalling. Seven NADPH oxidase isoforms, known as Noxs ( N APDH ox idases), are expressed in a cell- and tissue-specific fashion. These oxidases are thought to subserve distinct functions as a result of their tightly regulated activation (e.g. by neurohormonal and growth factors and mechanical...

... studies should give us a clearer picture of the role of phosphatase inactivation in cellular behaviour and explain how specificity is achieved in redox signalling. 1 To whom correspondence should be addressed (email [email protected] ). 8 7 2004 © 2004 The Biochemical Society...

...E.K. Ceaser; D.R. Moellering; S. Shiva; A. Ramachandran; A. Landar; A. Venkartraman; J. Crawford; R. Patel; D.A. Dickinson; E. Ulasova; S. Ji; V.M. Darley-Usmar Cellular redox signalling is mediated by the post-translational modification of proteins by reactive oxygen/nitrogen species...

... 1 July 2003 © 2003 Biochemical Society 2003 antioxidant lipophilic cation mitochondria oxidative stress reactive oxygen species redox signalling Abbreviations used: Δμ H + , proton electrochemical potential gradient; ΔpH, pH gradient; Δψ, membrane potential; Δψ m...