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Keywords: regulation
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Biochem Soc Trans (2023) 51 (3): 1347–1360.
Published: 02 June 2023
... by the technological advancements in cryo-EM analysis, which has elucidated many new P-type ATPase structures and mechanisms and revealed several new ways of regulation. In this review, we highlight the progress of the field and focus on special features that are present in the five subfamilies. Hence, we outline...
Articles
Biochem Soc Trans (2023) 51 (3): 1201–1212.
Published: 04 May 2023
.... We then discuss the evidence linking CD56 − CD16 + NK cells to chronic virus infections, and the potential immunological pathways that are altered by long-term infection that could be inducing the population's differentiation. An important aspect of NK cell regulation is their interaction with human...
Articles
Biochem Soc Trans (2021) 49 (2): 541–550.
Published: 23 April 2021
... organisms has some unique features not present in other bacterial or mitochondrial systems. Among these is a larger-than-average transmembrane rotor ring and a redox-regulated switch capable of inhibiting ATP hydrolysis activity in the dark by uniquely adapted rotor subunit modifications. Here, we review...
Articles
Biochem Soc Trans (2019) 47 (2): 671–677.
Published: 08 March 2019
... genes controlled by MarA, we recently mapped binding of the regulator across the E. coli genome. As expected, many MarA targets were adjacent to genes encoding stress response systems. Surprisingly, one MarA-binding site overlapped the lac operon regulatory region. Here, we show that MarA specifically...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (2): 679–689.
Published: 05 March 2019
... ]. Correspondence: Amber Riaz-Bradley ( [email protected] ) 8 11 2018 11 1 2019 4 2 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cyanobacteria regulation RNA transcription The first stage of gene...
Articles
Biochem Soc Trans (2014) 42 (4): 1112–1117.
Published: 11 August 2014
... interactions and the regulation of gene expression. The biosynthesis of CoA requires pantothenic acid, cysteine and ATP, and involves five enzymatic steps that are highly conserved from prokaryotes to eukaryotes. The intracellular levels of CoA and its derivatives change in response to extracellular stimuli...
Articles
Biochem Soc Trans (2013) 41 (6): 1551–1556.
Published: 20 November 2013
... schizophrenia susceptibility [ 13 ]. Unravelling the factors modulating the functionality of the enzymes involved in the regulation of D -serine cellular levels (in particular DAAO) is of outstanding interest, since this might improve our understanding of the molecular mechanisms involved in complex...
Articles
Biochem Soc Trans (2010) 38 (5): 1210–1214.
Published: 24 September 2010
... 2 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 Shared control has disadvantages in terms of regulation of pathways, in that it is difficult to increase the flux of the pathway substantially without activating every single enzyme to a similar extent [ 11 , 12...
Articles
Biochem Soc Trans (2005) 33 (4): 737–742.
Published: 01 August 2005
... regulated to ensure a continuous supply to the cognate apoproteins. This may induce strong competition between different branches of the pathway for common substrates. In addition, the intermediates, which are phototoxic, must not be allowed to accumulate in the cell. The major control points are during...
Articles
Biochem Soc Trans (2005) 33 (3): 507–515.
Published: 01 June 2005
...O. Wolkenhauer; S.N. Sreenath; P. Wellstead; M. Ullah; K.-H. Cho A mathematical understanding of regulation, and, in particular, the role of feedback, has been central to the advance of the physical sciences and technology. In this article, the framework provided by systems biology is used to argue...
Articles
Biochem Soc Trans (2005) 33 (1): 134–136.
Published: 01 February 2005
.... Under aerobic conditions, nitrite has no effect and aniA expression remains very low, indicating that oxygen availability must become limited before nitrite can exert a regulatory effect on p aniA . The presence of a functional FNR (oxygen sensor-regulator) and NarQP (nitrate/nitrite two-component...
Articles
Biochem Soc Trans (2002) 30 (4): 766–768.
Published: 01 August 2002
... and convergences of the iron, copper and zinc uptake, transport and homoeostatic pathways. 1 To whom correspondence should be addressed (e-mail [email protected] ) 13 3 2002 © 2002 Biochemical Society 2002 Arabidopsis metal nutrition regulation Biometals 2002: Third...
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Articles
Biochem Soc Trans (2000) 28 (6): 607–610.
Published: 01 December 2000
... the transfer reaction, with 50% inhibition at 0.17 μM ACP close to the physiological concentration of ACP (0.13 μM). KAS I and II also differ in carrying out the decarboxylation step of the elongation reaction. acyl carrier protein fatty acid synthase β-ketoacyl synthase regulation transfer assay...