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Keywords: reperfusion injury
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Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
...), the adenine nucleotide translocase and the phosphate carrier are summarized and other potential interactions with outer mitochondrial membrane proteins are discussed. I then review the evidence that MPTP opening mediates cardiac reperfusion injury and that MPTP inhibition is cardioprotective. Inhibition may...
Biochem Soc Trans (2000) 28 (2): 170–177.
Published: 01 February 2000
... nucleotide translocase (ANT) bound to matrix cyclophilin-D and we have now demonstrated this directly by reconstitution of the pure components. Opening of the MPTP causes swelling and uncoupling of mitochondria which, unrestrained, leads to necrosis. In ischaemia/reperfusion injury of the heart we have shown...