... functions of these proteins on endo-lysosomal compartments have emerged. PROPPINs support the division of these organelles and the formation of tubulo-vesicular cargo carriers that mediate protein exit from them, such as those generated by the Retromer coat. In both cases, PROPPINs provide membrane fission...

...Matthew Gallon; Peter J. Cullen The evolutionarily conserved endosomal retromer complex rescues transmembrane proteins from the lysosomal degradative pathway and facilitates their recycling to other cellular compartments. Retromer functions in conjunction with numerous associated proteins...

... [email protected] 4 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Bin/amphiphysin/Rvs domain (BAR domain) endosome phosphoinositide retromer sorting nexin (SNX) A vital element in the biology of phosphoinositides is their rapid inter...