... is an excellent vehicle for retrotransposon-mediated genomic rearrangements by virtue of the high levels of (retrotransposon) RNA present in the ooplasm [ 23 ]. As illuminated by speakers from the previous session, LINE-1s have the potential to generate new gene constructs by juxtaposing reverse transcriptase...

...) was not examined. Using degenerate primers to conserved regions of reverse transcriptase specific for each of nine HERV families, we have detected expression of six HERV families in epididymis and three in testis. Differential HERV expression may reflect the fully differentiated state of epididymal epithelium...

... bind to the RNase H domain of the HIV RT (reverse transcriptase) have been isolated from nucleic acid libraries using combinatorial selection methods. The selected thioaptamer inhibited RNase H activity of the HIV RT in in vitro studies. In cell cultures, the transfected thioaptamer markedly reduced...