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Keywords: ribosome biogenesis
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Biochem Soc Trans (2024) 52 (1): 395–405.
Published: 13 February 2024
... to have many cellular roles, including in pre-mRNA splicing, innate immune sensing, ribosome biogenesis, translational regulation, and R-loop metabolism. In this review, we will summarize the latest understandings regarding the various roles of DDX41, as well as highlight challenges associated with drug...
Biochem Soc Trans (2021) 49 (2): 727–745.
Published: 30 April 2021
... , 110 ]. Era ribosome biogenesis uS11 YbeY All studied YbeY homologues are critically important for cell physiology. Their loss may be lethal, as in Haemophilus influenzae or Bacillus subtilis [ 7–9 ], or result in pleiotropic phenotypes hardly compatible with survival in the wild...
Biochem Soc Trans (2016) 44 (4): 1035–1044.
Published: 15 August 2016
... in proteins involved in the global process of ribosome biogenesis, result in tissue-specific defects. The questions posed by this dichotomy and the steps taken to address these questions are therefore the focus of this review: How can tissue-specific disorders result from alterations in global processes...
Biochem Soc Trans (2014) 42 (4): 1224–1228.
Published: 11 August 2014
...Tina McLeod; Akilu Abdullahi; Min Li; Saverio Brogna The nucleolus is the most prominent morphological feature within the nucleus of eukaryotic cells and is best known for its role in ribosome biogenesis. It forms around highly transcribed ribosomal RNA gene repeats which yield precursor rRNAs...
Biochem Soc Trans (2013) 41 (4): 923–926.
Published: 18 July 2013
... ]), although additional mechanisms may also be involved. mTORC1 activates Pol III by alleviating its inhibition by Maf1 [ 17 , 18 ]. mTORC1 co-localizes with Maf1 and promotes its phosphorylation. Given the complexity of ribosome biogenesis, with the necessity to generate sufficient quantities of almost 80...