... to have many cellular roles, including in pre-mRNA splicing, innate immune sensing, ribosome biogenesis, translational regulation, and R-loop metabolism. In this review, we will summarize the latest understandings regarding the various roles of DDX41, as well as highlight challenges associated with drug...

...David Shore; Sevil Zencir; Benjamin Albert Ribosome biogenesis requires prodigious transcriptional output in rapidly growing yeast cells and is highly regulated in response to both growth and stress signals. This minireview focuses on recent developments in our understanding of this regulatory...

... ] Surprisingly, after nearly two decades of research, our understanding of how YbeY works, why it is so important for bacteria and the derived eukaryotic organelles remains rather limited. Current evidence implicates YbeY in key gene expression processes, such as ribosome biogenesis, quality control and turnover...

... in proteins involved in the global process of ribosome biogenesis, result in tissue-specific defects. The questions posed by this dichotomy and the steps taken to address these questions are therefore the focus of this review: How can tissue-specific disorders result from alterations in global processes...

...Tina McLeod; Akilu Abdullahi; Min Li; Saverio Brogna The nucleolus is the most prominent morphological feature within the nucleus of eukaryotic cells and is best known for its role in ribosome biogenesis. It forms around highly transcribed ribosomal RNA gene repeats which yield precursor rRNAs...

... to the dephosphorylation and activation of eEF2. 1 email [email protected] 20 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 eukaryotic elongation factor 2 (eEF2) mammalian target of rapamycin complex 1 (mTORC1) mRNA translation ribosome biogenesis rRNA...

... in ribosome biogenesis. S6Ks are implicated in the control of cell and organismal growth [ 2 – 4 ]. Control of protein synthesis makes an important contribution to cell growth and division. This is for several reasons: (i) the bulk of the dry mass of cells is protein, so increased cell growth or cell...

... high-yielding conditions by using the doxycycline-repressible tetO system. This revealed an additional three candidate genes that might have a role in increasing the yield per cell of our membrane protein ( Figure 2 ). Most notable among them was BMS1 , which is involved in ribosome biogenesis...