... to cells, allowing for a selection process to occur and leading to tumorigenesis even in the case of reversible or unstable epigenetic states. This review seeks to highlight how the fundamental epigenetic shifts in cancer contribute to tumorigenesis, and how understanding an integrated view of cancer...

... spaces for sRNA evolution. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bacteria exaptation ncRNA selection sRNAs transcriptional noise Far from being relics of a lost RNA world [ 1 ], most bacterial non-coding RNAs (ncRNAs...

...Robert C. Karn; Christina M. Laukaitis In the present article, we summarize two aspects of our work on mouse ABP (androgen-binding protein): (i) the sexual selection function producing incipient reinforcement on the European house mouse hybrid zone, and (ii) the mechanism behind the dramatic...

... the constraint of minimizing space utilization. For any biological process with multiple steps that compete for control in series, evolution by natural selection will tend to even out the control exerted by each step. This is for two reasons: (i) shared control maximizes the flux for minimum protein...