...Vinesh Dhokia; Amal Albati; Hannah Smith; Gethin Thomas; Salvador Macip Cellular senescence, a form of terminal cell cycle arrest, is as a key driver of organismal ageing and an important factor in age-related diseases. Insights into the senescent phenotype have led to the development of novel...

...Hilary J. Rogers Floral senescence is of fundamental interest in understanding plant developmental regulation, it is of ecological and agricultural interest in relation to seed production, and is of key importance to the production of cut flowers. The biochemical changes occurring are well-studied...

.... Progerin expression results in a myriad of cellular phenotypes including abnormal nuclear morphology, loss of peripheral heterochromatin, transcriptional changes, DNA replication defects, DNA damage and premature cellular senescence. A key challenge is to elucidate how these different phenotypes...

...Kristina Kirschner; Nattaphong Rattanavirotkul; Megan F. Quince; Tamir Chandra Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence...

... that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases...

... of rapamycin (mTOR) to be a key modulator of aging and the use of mTOR inhibitors has been shown to ameliorate much age-related pathology; however, recent data suggest that senescent CD8 + T-cells function independently of mTOR. This review article will challenge the perceived dogma that mTOR universally...

... ]. 1 To whom correspondence should be addressed (email [email protected] ). 20 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 aging cancer senescence skin stem cell Aging is a complex and detrimental process that is experienced by all living...

... Society 2011 alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles in its regulation, organization and maintenance [ 1 ]. The nuclear envelope...

...-injury results in the eventual failure of epithelial cell repair due to replicative senescence are gaining favour. This is consistent with the onset of fibrotic diseases in middle age. Because epithelial injury often involves blood loss, inflammatory responses associated with the fibrotic response have...

... proliferation. However, hallmarks of OIS (oncogene-induced senescence) are evident that restrain further development of the tumour. 1 To whom correspondence should be addressed (email [email protected] ). 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 BRAF...

... cancer as an example. 1 email [email protected] 16 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Cells show a wide range of responses upon exposure to RS, ranging from increased proliferation, prevention of cell division, senescence, necrosis...

... observed that senescent cells have higher levels of SM22/transgelin. Additionally, reduced levels of SM22 have been reported in several tumour cell lines [ 29 ]. Further studies on yeast and mammalian cells might now shed light on the process of cell aging and, in particular, how this process is linked...

... motility, while ROS have also been implicated in apoptosis and cellular senescence, two mechanisms regarded as being anti-tumorigenic. This ‘two-faced’ character of free radicals will be discussed and placed in the context of the physiological conditions of the tumour cell, the different molecular...

... will necessarily be enriched in individuals that age more slowly than the average of that population. However, some investigators have suggested that, instead, individuals actually cease to senesce after a certain age. Here, using a new approach to determining the best-fit degree of heterogeneity in the Gompertz...

... on Earth, observable even from outer space [24 ] . Only in the last decade has the breakdown of chlorophyll in plants begun to yield some of its mysteries [2-61. Matile and co-workers provided the first evidence for the presence of non-green chlorophyll catabolites in senescent leaves of vas- cular plants...

... factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological...

... in animals and humans. Although the evidence is strong that telomere shortening in late-passage human lymphocyte and non-lymphocytic cell lines induces a state in which the cells can no longer divide, there is no compelling evidence to suggest that replicative senescence of this kind is an important...