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Keywords: sepsis
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Biochem Soc Trans (2023) 51 (2): 887–896.
Published: 26 April 2023
...), early-onset sepsis and late-onset sepsis. To date, no single bacterium has been associated with infection in these infants, but a Klebsiella / Enterococcus -dominated faecal microbiota is associated with an increased risk of developing NEC. Staphylococci aid and enterococci inhibit establishment...
Includes: Supplementary data
Biochem Soc Trans (2020) 48 (1): 1–14.
Published: 12 February 2020
...Inge Grondman; Andrei Pirvu; Anca Riza; Mihai Ioana; Mihai G. Netea Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a dysregulated host response to infection. The main etiological causes of sepsis are bacterial, fungal, and viral infections. Last decades...
Includes: Supplementary data
Biochem Soc Trans (2015) 43 (4): 715–719.
Published: 03 August 2015
... important interactions in the pathogenesis of cardiovascular infection. These interactions can trigger cardiac valve destruction in the case of endocarditis, multi-organ dysfunction in the case of sepsis and coagulopathy. Here, we review the interactions between S. aureus and endothelial cells and discuss...
Biochem Soc Trans (2015) 43 (4): 691–695.
Published: 03 August 2015
...) for the treatment of severe sepsis. Although originally deemed successful, Xigris was ultimately withdrawn due to lack of efficacy and an unacceptable bleeding risk. Despite this apparent failure, the problems that beset Xigris usage may be tractable using protein engineering approaches. In this review, we detail...
Biochem Soc Trans (2007) 35 (5): 1264–1268.
Published: 25 October 2007
... activities under hypoxic conditions [ 8 ]. The carotid chemoreceptor response to hypoxia was found to be markedly exaggerated in spontaneously hypertensive rats [ 9 ]. In acute inflammation, for example during bacterial sepsis, marked increases in ventilatory drive in critically ill patients occur often...
Biochem Soc Trans (2006) 34 (6): 1028–1031.
Published: 25 October 2006
.... Gabrilovich D. Heller R. Coppola D. Nat. Med. 2004 10 48 54 immune response inflammation interleukin-10 (IL-10) macrophage sepsis signal transducer and activator of transcription 3 (STAT3) Both the adaptive and innate arms of the mammalian immune response have developed...
Biochem Soc Trans (2005) 33 (2): 401–405.
Published: 01 April 2005
... NE 13th Street, Oklahoma City, OK 73104, U.S.A. (email Charles-esmon@omrf.ouhsc.edu ). 17 9 2004 © 2005 The Biochemical Society 2005 blood coagulation endothelial cell protein C receptor inflammation protein C sepsis thrombosis Inflammatory mediators trigger...
Biochem Soc Trans (2003) 31 (6): 1133–1136.
Published: 01 December 2003
... decarboxylase in response to, for example, alterations in glucose supply. Systemic inflammatory responses and sepsis lead to myocardial dysfunction as part of multiple system organ failure. We have shown that: (i) myocardial CPT I activity is inhibited during neonatal sepsis; (ii) on the basis of inhibitor...