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Keywords: serine proteinase
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13 C- and 1 H-NMR studies of oxyanion and tetrahedral intermediate stabilization by the serine proteinases: optimizing inhibitor warhead specificity and potency by studying the inhibition of the serine proteinases by peptide-derived chloromethane and glyoxal inhibitors

J.P.G. Malthouse
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 566–570.
https://doi.org/10.1042/BST0350566
Published: 22 May 2007
...J.P.G. Malthouse Catalysis by the serine proteinases proceeds via a tetrahedral intermediate whose oxyanion is stabilized by hydrogen-bonding in the oxyanion hole. There have been extensive 13 C-NMR studies of oxyanion and tetrahedral intermediate stabilization in trypsin, subtilisin...
View article titled, 13 C- and 1 H-NMR studies of oxyanion and tetrahedral intermediate stabilization by the <span class="search-highlight">serine</span> <span class="search-highlight">proteinases</span>: optimizing inhibitor warhead specificity and potency by studying the inhibition of the <span class="search-highlight">serine</span> <span class="search-highlight">proteinases</span> by peptide-derived chloromethane and glyoxal inhibitors
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