...Xiyuan Bai; Tony Schountz; Ashley M. Buckle; Janet L. Talbert; Robert A. Sandhaus; Edward D. Chan Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID-19. Herein, we...

...David J. Wilkinson Serpins ( ser ine p roteinase in hibitor s ) are an ancient superfamily of structurally similar proteins, the majority of which use an elegant suicide inhibition mechanism to target serine proteinases. Despite likely evolving from a single common ancestor, the 36 human serpins...

...D.A. Lomas; D. Belorgey; M. Mallya; E. Miranda; K.J. Kinghorn; L.K. Sharp; R.L. Phillips; R. Page; A.S. Robertson; D.C. Crowther Members of the serine proteinase inhibitor or serpin superfamily inhibit their target proteinases by a remarkable conformational transition that involves the enzyme being...