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Keywords: signalling
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (01): 145–159.
Published: 05 February 2025
... and in response to different signals. This review will illustrate these mechanisms by examining recent work on four serine/threonine kinases: Aurora B, CaMKII, GSK3β, and CK1δ. We find that these mechanisms are often shared by this diverse set of kinases in diverse cellular contexts, so they may represent common...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1035–1044.
Published: 25 April 2024
... neurodegeneration remains highly debated. Here, we discuss known links between embryonic neurogenesis and neurodegenerative disorders (including common signaling pathways), potential compensatory mechanisms that could delay presentation of neurodegenerative disorders, and the types of model systems that could...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 567–580.
Published: 17 April 2024
...Azmi Khan; Manisha Mallick; Jayashree S. Ladke; Rashna Bhandari The maintenance of phosphate homeostasis serves as a foundation for energy metabolism and signal transduction processes in all living organisms. Inositol pyrophosphates (PP-InsPs), composed of an inositol ring decorated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 517–527.
Published: 04 April 2024
...Neil J. Ball; Samuel F. H. Barnett; Benjamin T. Goult Cellular signalling is a complex process and involves cascades of enzymes that, in response to a specific signal, give rise to exact cellular responses. Signalling scaffold proteins organise components of these signalling pathways in space...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1143–1155.
Published: 12 June 2023
... a perspective on the potential relevance of this receptor as a therapeutic target for solid tumours. Correspondence: Maddy Parsons ( [email protected] ) cancer cell adhesion signalling 15 1 2023 31 5 2023 1 6 2023 © 2023 The Author(s) 2023 This is an open access...
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Awards
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 13–20.
Published: 23 January 2023
...Maria Marti-Solano G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of biomolecules to activate intracellular signalling cascades that modulate key aspects of cell physiology. Apart from their crucial role in maintaining cell homeostasis, these critical sensory...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1227–1243.
Published: 13 June 2022
... 24 5 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 aryl hydrocarbon receptor bHLH–PAS transcription factors hypoxia inducible factors signalling transcription The basic helix-loop-helix Per-Arnt-Sim family...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1105–1118.
Published: 19 May 2022
... interactions to signal apoptosis. Fas/CD95 death receptor-mediated apoptosis requires the formation of the so-called d eath- i nducing s ignaling c omplex (DISC), bringing together Fas/CD95, Fas-associated death domain-containing protein and procaspase-8. In the last two decades, cholesterol-rich lipid raft...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1171–1188.
Published: 22 June 2021
... in PKD is due to mutations in cilia-localising genes, resulting in changes in cellular signalling. As such, compounds that are currently in preclinical and clinical trials target some of these signalling pathways that are dysregulated in PKD. In this review, we highlight these pathways including cAMP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1385–1395.
Published: 01 June 2021
... to be considered as therapeutic targets. In the past two decades, around 45 drugs targeting chemokine receptors have been developed, yet only three are clinically approved. The challenging factors include the limited understanding of aberrant chemokine signalling in malignant diseases, high redundancy...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 335–345.
Published: 11 January 2021
... sciences. In recent years, the chemogenetic DAAO approach has proven beneficial to establish a new role for (patho)physiological oxidative stress on redox-dependent signaling and metabolic pathways in cultured cells and animal model systems. This mini-review covers established or emerging methods...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2015–2027.
Published: 14 October 2020
... by Leucine carboxyl methyltransferase-1 (LCMT1) that utilizes S-adenosyl-methionine (SAM) as the methyl donor and removed by protein phosphatase methylesterase 1 (PME1). For PP2A, methylation dictates regulatory subunit selection and thereby downstream phosphorylation signaling. Intriguingly, there are four...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
...Harrison M. York; Joanne Coyle; Senthil Arumugam Living cells interpret a variety of signals in different contexts to elucidate functional responses. While the understanding of signalling molecules, their respective receptors and response at the gene transcription level have been relatively well...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 95–101.
Published: 12 February 2020
..., the limitations of the current detection methods and the urgent need to understand how this polymer is synthesized. cell metabolism inorganic polyphosphates phosphate post translational modification signalling Arthur Kornberg and Igor Kulaev spent a large part of their careers working on inorganic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1291–1305.
Published: 28 October 2019
...David Barneda; Sabina Cosulich; Len Stephens; Phillip Hawkins The phosphoinositide (PIPn) family of signalling phospholipids are central regulators in membrane cell biology. Their varied functions are based on the phosphorylation pattern of their inositol ring, which can be recognized by selective...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1355–1366.
Published: 11 October 2019
... is to understand how the activity of PKA C subunits is spatially and temporally controlled in cells. Obtaining a detailed understanding of the molecular basis of PKA targeting may reveal novel strategies for pharmacological targeting of cAMP signalling. PKA activity is controlled in part by association...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1415–1427.
Published: 11 October 2019
...Urszula Luchowska-Stańska; David Morgan; Stephen J. Yarwood; Graeme Barker The cellular signalling enzymes, EPAC1 and EPAC2, have emerged as key intracellular sensors of the secondary messenger cyclic 3′,5′-adenosine monophosphate (cyclic adenosine monophosphate) alongside protein kinase...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1673–1680.
Published: 04 December 2018
...Lilian Schimmel; Emma Gordon Endothelial cell–cell adhesion within the wall of the vasculature controls a range of physiological processes, such as growth, integrity and barrier function. The adhesive properties of endothelial cells are tightly controlled by a complex cascade of signals transmitted...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1681–1695.
Published: 12 November 2018
... on target proteins or in the form of ADP-ribose chains, with the latter called poly(ADP-ribosyl)ation. PARPs regulate many cellular processes, including the maintenance of genome stability and signal transduction. In this review, we focus on the PARP family members that possess the ability to modify...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1325–1332.
Published: 04 October 2018
...Stephanie P. Mo; Judy M. Coulson; Ian A. Prior RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1063–1072.
Published: 21 September 2018
...Christian Makhoul; Prajakta Gosavi; Paul A. Gleeson An array of signalling molecules are located at the Golgi apparatus, including phosphoinositides, small GTPases, kinases, and phosphatases, which are linked to multiple signalling pathways. Initially considered to be associated predominantly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 391–401.
Published: 14 March 2018
... specificities recognised by CAR-T cells will broaden tumour antigen coverage, potentially overcoming tumour heterogeneity and limiting tumour antigen escape. Tuning the balance of signalling within bi-specific CAR-T cells may enable tumour targeting while sparing normal tissues, and thus minimise on-target, off...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 453–466.
Published: 22 February 2018
...Miriam Walden; Safi Kani Masandi; Krzysztof Pawłowski; Elton Zeqiraj The ubiquitin (Ub) proteasome system and Ub signalling networks are crucial to cell biology and disease development. Deubiquitylases (DUBs) control cell signalling by removing mono-Ub and polyubiquitin chains from substrates. DUBs...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
... ubiquitin chain types and linkages can play significantly different roles in cell signalling, but differentiating and quantifying these chain types is inherently challenging, often requiring the use of antibodies — although for several chain types no specific antibodies are available. Fortunately, MS...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
...Annette V. Jacobsen; James M. Murphy Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise ∼10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 293–298.
Published: 09 February 2016
...-established and potential new roles for phosphoinositides in β-cell function/dysfunction and discuss how our knowledge of phosphoinositide signalling could aid in the identification of potential strategies for treating or preventing type 2 diabetes. © 2016 Authors; published by Portland Press Limited 2016...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 13–17.
Published: 09 February 2016
... conditions. Polyphosphorylation detection was only possible through extensive biochemical characterization. Two targets have been identified: nuclear signal recognition 1 (Nsr1) and its interacting partner, topoisomerase 1 (Top1). Polyphosphorylation occurs within a conserved N-terminal p oly a cidic serine...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 1049–1050.
Published: 09 October 2015
...Endre Kiss-Toth; Guillermo Velasco; Warren S. Pear 1 To whom correspondence should be addressed (email [email protected] ) . 2 6 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer lipids metabolism signalling tribbles ubiquitin...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 1051–1056.
Published: 09 October 2015
...Andrew D. Rowan; Gary J. Litherland The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 687–689.
Published: 03 August 2015
... physiological and pathological processes has become widely recognized; these include redox signalling and redox homoeostasis, drug metabolism and disposition, intermediary metabolism, cellular adaptation to stress, chemoprevention and chemoresistance, toxicity, inflammation, neurodegeneration, lipogenesis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (1): 97–103.
Published: 26 January 2015
... to nutrient signalling, thus coupling environmental stimuli to secretory capacity. 1 To whom correspondence should be addressed (email [email protected] ) . 10 11 2014 After synthesis in the ER, newly synthesized cargo leave the ER at dedicated sites called ER exit sites (ERESs...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1311–1315.
Published: 18 September 2014
..., the signalling pathways eliciting glycogen degradation inside astrocytes are themselves energy-demanding processes, a fact that has been emphasized in recent studies, demonstrating dependence of these signalling mechanisms on glycogenolytic ATP. Degradation and synthesis of glycogen are regulated in opposing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1349–1355.
Published: 18 September 2014
...-kinase (PI3K)/Akt signalling cascade. Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism. Strikingly, non-redundant and even opposing functions of Akt isoforms in the regulation of phenotypes associated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 934–938.
Published: 11 August 2014
... with such signalling properties, and this molecule has been shown to affect a wide range of cellular functions. Its localized synthesis by the Nox (NADPH oxidase) family of enzymes and how these enzymes are regulated is of particular interest to those who work in the field of tumour biology. 1 To whom...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... be the result of genomic alterations such as PIK3CA mutation, PTEN (phosphatase and tensin homologue deleted on chromosome 10) loss or the activation of upstream protein tyrosine kinases. Not surprisingly, the PI3K signalling pathway has become an attractive therapeutic target, and numerous inhibitors...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 846–850.
Published: 11 August 2014
...John A. Pickett; Stephen Barasa; Michael A. Birkett The interaction between volatile and non-volatile, e.g. proteinaceous, components of pheromone and other semiochemical-based signalling systems presents a daunting set of problems for exploitation in the management of vertebrates, good or bad...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 965–970.
Published: 11 August 2014
... (reactive nitrogen species) necessary for the regulation of many proteins involved in excitation–contraction coupling. The magnitude and species of ROS/RNS generated by contracting muscles will have downstream effects on specific protein targets and cellular redox signalling. Redox modifications on specific...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
...Rebecca J. Holley; Kate A. Meade; Catherine L.R. Merry Differentiation and subsequent specialization of every cell within an organism is an intricate interwoven process. A complex network of signalling pathways eventually leads to the specification of a multitude of different cell types able...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling The IMS is the second aqueous compartment of mitochondria (the other being the matrix). The IMS is defined by the OMM and IMM and has emerged as a significant regulatory domain in the co-ordination...
Articles
Stephen Boulton, Madoka Akimoto, Bryan VanSchouwen, Kody Moleschi, Rajeevan Selvaratnam, Rajanish Giri, Giuseppe Melacini
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 302–307.
Published: 20 March 2014
...-dependent signalling pathways has a high translational potential. However, the ubiquity of eukaryotic CBDs also poses a challenge in terms of selectivity. Before the full translational potential of cAMP signalling can be tapped, it is critical to understand the structural basis for selective cAMP agonism...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
[email protected] ). 5 8 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Embryogenesis and neuronal development is controlled by central signalling pathways, such as Shh, TGFβ and Wnt. In embryogenesis, these pathways are essential for patterning, formation of the body axis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 887–888.
Published: 18 July 2013
... of ensuring its own clear nomenclature system, solve the problem on its own. Much like the TOR community has continued to use the name raptor instead of rptor, I suggest that we continue to use mammalian TOR (mTOR). The highly conserved TOR (target of rapamycin) signalling network is studied by a wide...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 995–1001.
Published: 18 July 2013
..., cytoskeletal remodelling, vesicular traffic and signalling are important tasks for future research. Exploring Kinomes: Pseudokinases and Beyond: A Biochemical Society Focused Meeting held at Robinson College, Cambridge, U.K., 24–26 March 2013. Organized by Dario Alessi (Dundee, U.K.), Patrick Eyers...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 939–943.
Published: 18 July 2013
... translation. In order for cells to control cellular homoeostasis during growth, there is close signalling interplay between mTORC1 and two other protein kinases, AMPK (AMP-activated protein kinase) and ULK1 (Unc-51-like kinase 1). This kinase triad collectively senses the energy and nutrient status...
Articles
Olli Silvennoinen, Daniela Ungureanu, Yashavanthi Niranjan, Henrik Hammaren, Rajintha Bandaranayake, Stevan R. Hubbard
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 1002–1007.
Published: 18 July 2013
...Olli Silvennoinen; Daniela Ungureanu; Yashavanthi Niranjan; Henrik Hammaren; Rajintha Bandaranayake; Stevan R. Hubbard JAK (Janus kinase) 2 plays a critical role in signal transduction through several cytokine receptors. JAKs contain a typical tyrosine kinase domain preceded by a pseudokinase [JH2...
Articles
Sophie Mary, Jean-Alain Fehrentz, Marjorie Damian, Pascal Verdié, Jean Martinez, Jacky Marie, Jean-Louis Banères
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 144–147.
Published: 29 January 2013
...Sophie Mary; Jean-Alain Fehrentz; Marjorie Damian; Pascal Verdié; Jean Martinez; Jacky Marie; Jean-Louis Banères The dynamic character of GPCRs (G-protein-coupled receptors) is essential to their function. However, the details of how ligands and signalling proteins stabilize a receptor conformation...
Articles
Sharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis, Ian A. Prior
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... to influence the spatiotemporal signalling of Ras. 1 Correspondence may be addressed to either of these authors (email [email protected] or [email protected] ). 15 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 compartmentalization nanocluster...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (6): 1512–1516.
Published: 21 November 2012
... To whom correspondence should be addressed (email [email protected] ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin biodiversity evolution quorum sensing signalling A recent study of the microbiomes of 242 healthy individuals found 1221...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 311–323.
Published: 21 March 2012
...Alena Krejčí There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription. Central metabolic pathways are under the control of signalling pathways and, vice versa, the cellular metabolic profile influences cell signalling through...
Articles
Catherine Andreadi, Catherine Noble, Bipin Patel, Hong Jin, Maria M. Aguilar Hernandez, Kathryn Balmanno, Simon J. Cook, Catrin Pritchard
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 67–72.
Published: 19 January 2012
...Catherine Andreadi; Catherine Noble; Bipin Patel; Hong Jin; Maria M. Aguilar Hernandez; Kathryn Balmanno; Simon J. Cook; Catrin Pritchard The strength and duration of intracellular signalling pathway activation is a key determinant of the biological outcome of cells in response to extracellular...
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