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Keywords: signalling
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Articles
Biochem Soc Trans (2023) 51 (3): 1143–1155.
Published: 12 June 2023
... a perspective on the potential relevance of this receptor as a therapeutic target for solid tumours. cancer cell adhesion signalling © 2023 The Author(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative...
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Biochem Soc Trans (2023) 51 (1): 13–20.
Published: 23 January 2023
...Maria Marti-Solano G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of biomolecules to activate intracellular signalling cascades that modulate key aspects of cell physiology. Apart from their crucial role in maintaining cell homeostasis, these critical sensory...
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Biochem Soc Trans (2022) 50 (3): 1227–1243.
Published: 13 June 2022
... of the Biochemical Society 2022 aryl hydrocarbon receptor bHLH–PAS transcription factors hypoxia inducible factors signalling transcription The basic helix-loop-helix Per-Arnt-Sim family of proteins (bHLH–PAS) are transcription factors that regulate diverse biological functions ( Figure 1 ). bHLH...
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Biochem Soc Trans (2021) 49 (3): 1171–1188.
Published: 22 June 2021
... in PKD is due to mutations in cilia-localising genes, resulting in changes in cellular signalling. As such, compounds that are currently in preclinical and clinical trials target some of these signalling pathways that are dysregulated in PKD. In this review, we highlight these pathways including cAMP...
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Biochem Soc Trans (2021) 49 (3): 1385–1395.
Published: 01 June 2021
... to be considered as therapeutic targets. In the past two decades, around 45 drugs targeting chemokine receptors have been developed, yet only three are clinically approved. The challenging factors include the limited understanding of aberrant chemokine signalling in malignant diseases, high redundancy...
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Biochem Soc Trans (2022) 50 (1): 335–345.
Published: 11 January 2021
... sciences. In recent years, the chemogenetic DAAO approach has proven beneficial to establish a new role for (patho)physiological oxidative stress on redox-dependent signaling and metabolic pathways in cultured cells and animal model systems. This mini-review covers established or emerging methods...
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Biochem Soc Trans (2020) 48 (5): 2015–2027.
Published: 14 October 2020
... by Leucine carboxyl methyltransferase-1 (LCMT1) that utilizes S-adenosyl-methionine (SAM) as the methyl donor and removed by protein phosphatase methylesterase 1 (PME1). For PP2A, methylation dictates regulatory subunit selection and thereby downstream phosphorylation signaling. Intriguingly, there are four...
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Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
...Harrison M. York; Joanne Coyle; Senthil Arumugam Living cells interpret a variety of signals in different contexts to elucidate functional responses. While the understanding of signalling molecules, their respective receptors and response at the gene transcription level have been relatively well...
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Biochem Soc Trans (2020) 48 (1): 95–101.
Published: 12 February 2020
... modification signalling © 2020 The Author(s) 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Open access for this article was enabled by the participation...
Articles
Biochem Soc Trans (2019) 47 (5): 1291–1305.
Published: 28 October 2019
...David Barneda; Sabina Cosulich; Len Stephens; Phillip Hawkins The phosphoinositide (PIPn) family of signalling phospholipids are central regulators in membrane cell biology. Their varied functions are based on the phosphorylation pattern of their inositol ring, which can be recognized by selective...
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Biochem Soc Trans (2019) 47 (5): 1355–1366.
Published: 11 October 2019
... of the Biochemical Society 2019 anchoring cAMP protein kinase A signalling cAMP-dependent protein kinase, also known as protein kinase A (PKA), is the major intracellular receptor for the ubiquitous second messenger cAMP. Phosphorylation of protein substrates by PKA catalytic (C) subunits following...
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Biochem Soc Trans (2019) 47 (5): 1415–1427.
Published: 11 October 2019
...Urszula Luchowska-Stańska; David Morgan; Stephen J. Yarwood; Graeme Barker The cellular signalling enzymes, EPAC1 and EPAC2, have emerged as key intracellular sensors of the secondary messenger cyclic 3′,5′-adenosine monophosphate (cyclic adenosine monophosphate) alongside protein kinase...
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Biochem Soc Trans (2018) 46 (6): 1673–1680.
Published: 04 December 2018
...Lilian Schimmel; Emma Gordon Endothelial cell–cell adhesion within the wall of the vasculature controls a range of physiological processes, such as growth, integrity and barrier function. The adhesive properties of endothelial cells are tightly controlled by a complex cascade of signals transmitted...
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Biochem Soc Trans (2018) 46 (6): 1681–1695.
Published: 12 November 2018
... on target proteins or in the form of ADP-ribose chains, with the latter called poly(ADP-ribosyl)ation. PARPs regulate many cellular processes, including the maintenance of genome stability and signal transduction. In this review, we focus on the PARP family members that possess the ability to modify...
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Biochem Soc Trans (2018) 46 (5): 1325–1332.
Published: 04 October 2018
...Stephanie P. Mo; Judy M. Coulson; Ian A. Prior RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent...
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Biochem Soc Trans (2018) 46 (5): 1063–1072.
Published: 21 September 2018
...Christian Makhoul; Prajakta Gosavi; Paul A. Gleeson An array of signalling molecules are located at the Golgi apparatus, including phosphoinositides, small GTPases, kinases, and phosphatases, which are linked to multiple signalling pathways. Initially considered to be associated predominantly...
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Biochem Soc Trans (2018) 46 (2): 391–401.
Published: 14 March 2018
... specificities recognised by CAR-T cells will broaden tumour antigen coverage, potentially overcoming tumour heterogeneity and limiting tumour antigen escape. Tuning the balance of signalling within bi-specific CAR-T cells may enable tumour targeting while sparing normal tissues, and thus minimise on-target, off...
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Biochem Soc Trans (2018) 46 (2): 453–466.
Published: 22 February 2018
...Miriam Walden; Safi Kani Masandi; Krzysztof Pawłowski; Elton Zeqiraj The ubiquitin (Ub) proteasome system and Ub signalling networks are crucial to cell biology and disease development. Deubiquitylases (DUBs) control cell signalling by removing mono-Ub and polyubiquitin chains from substrates. DUBs...
Includes: Supplementary data
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Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
... of the Biochemical Society 2017 deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate...
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Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
...Annette V. Jacobsen; James M. Murphy Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise ∼10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies...
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Biochem Soc Trans (2016) 44 (1): 293–298.
Published: 09 February 2016
...-established and potential new roles for phosphoinositides in β-cell function/dysfunction and discuss how our knowledge of phosphoinositide signalling could aid in the identification of potential strategies for treating or preventing type 2 diabetes. Additionally, PtdIns(4,5) P 2 was found...
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Biochem Soc Trans (2016) 44 (1): 13–17.
Published: 09 February 2016
... conditions. Polyphosphorylation detection was only possible through extensive biochemical characterization. Two targets have been identified: nuclear signal recognition 1 (Nsr1) and its interacting partner, topoisomerase 1 (Top1). Polyphosphorylation occurs within a conserved N-terminal p oly a cidic serine...
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Biochem Soc Trans (2015) 43 (5): 1049–1050.
Published: 09 October 2015
...Endre Kiss-Toth; Guillermo Velasco; Warren S. Pear 1 To whom correspondence should be addressed (email e.kiss-toth@sheffield.ac.uk ) . 2 6 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer lipids metabolism signalling tribbles ubiquitin...
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Biochem Soc Trans (2015) 43 (5): 1051–1056.
Published: 09 October 2015
...Andrew D. Rowan; Gary J. Litherland The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction...
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Biochem Soc Trans (2015) 43 (4): 687–689.
Published: 03 August 2015
... physiological and pathological processes has become widely recognized; these include redox signalling and redox homoeostasis, drug metabolism and disposition, intermediary metabolism, cellular adaptation to stress, chemoprevention and chemoresistance, toxicity, inflammation, neurodegeneration, lipogenesis...
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Biochem Soc Trans (2015) 43 (1): 97–103.
Published: 26 January 2015
... to nutrient signalling, thus coupling environmental stimuli to secretory capacity. 1 To whom correspondence should be addressed (email c.rabouille@hubrecht.eu ) . 10 11 2014 After synthesis in the ER, newly synthesized cargo leave the ER at dedicated sites called ER exit sites (ERESs...
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Biochem Soc Trans (2014) 42 (5): 1311–1315.
Published: 18 September 2014
..., the signalling pathways eliciting glycogen degradation inside astrocytes are themselves energy-demanding processes, a fact that has been emphasized in recent studies, demonstrating dependence of these signalling mechanisms on glycogenolytic ATP. Although the somata of noradrenergic neurons are confined to two...
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Biochem Soc Trans (2014) 42 (5): 1349–1355.
Published: 18 September 2014
...-kinase (PI3K)/Akt signalling cascade. Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism. Strikingly, non-redundant and even opposing functions of Akt isoforms in the regulation of phenotypes associated...
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Biochem Soc Trans (2014) 42 (4): 965–970.
Published: 11 August 2014
... (reactive nitrogen species) necessary for the regulation of many proteins involved in excitation–contraction coupling. The magnitude and species of ROS/RNS generated by contracting muscles will have downstream effects on specific protein targets and cellular redox signalling. Redox modifications on specific...
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Biochem Soc Trans (2014) 42 (4): 934–938.
Published: 11 August 2014
... with such signalling properties, and this molecule has been shown to affect a wide range of cellular functions. Its localized synthesis by the Nox (NADPH oxidase) family of enzymes and how these enzymes are regulated is of particular interest to those who work in the field of tumour biology. 1 To whom...
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Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... be the result of genomic alterations such as PIK3CA mutation, PTEN (phosphatase and tensin homologue deleted on chromosome 10) loss or the activation of upstream protein tyrosine kinases. Not surprisingly, the PI3K signalling pathway has become an attractive therapeutic target, and numerous inhibitors...
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Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
...Rebecca J. Holley; Kate A. Meade; Catherine L.R. Merry Differentiation and subsequent specialization of every cell within an organism is an intricate interwoven process. A complex network of signalling pathways eventually leads to the specification of a multitude of different cell types able...
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Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling The IMS is the second aqueous compartment of mitochondria (the other being the matrix). The IMS is defined by the OMM and IMM and has emerged as a significant regulatory domain in the co-ordination...
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Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
... autophagy regulators, including ULK1 and ULK2 (mammalian Atg1 orthologues), Atg13 and FIP200 [FAK (focal adhesion kinase)-family interacting protein of 200 kDa] [ 3 ]. autophagy degradation development embryogenesis neurogenesis signalling Autophagy is an evolutionarily conserved...
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Biochem Soc Trans (2013) 41 (4): 887–888.
Published: 18 July 2013
... email M.Hall@unibas.ch Talks About TORCs: Recent Advances in Target of Rapamycin Signalling: A Biochemical Society Focused Meeting held at Charles Darwin House, London, U.K., 14–15 March 2013. Organized by Dario Alessi (Dundee, U.K.) and Christopher Proud (Southampton, U.K.). Edited...
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Biochem Soc Trans (2013) 41 (4): 995–1001.
Published: 18 July 2013
... correspondence should be addressed (email wickstroem@age.mpg.de ). 23 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 actin cell adhesion extracellular matrix integrin-linked kinase (ILK) pseudokinase signalling In order to establish and maintain...
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Biochem Soc Trans (2013) 41 (4): 939–943.
Published: 18 July 2013
... translation. In order for cells to control cellular homoeostasis during growth, there is close signalling interplay between mTORC1 and two other protein kinases, AMPK (AMP-activated protein kinase) and ULK1 (Unc-51-like kinase 1). This kinase triad collectively senses the energy and nutrient status...
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Biochem Soc Trans (2013) 41 (4): 1002–1007.
Published: 18 July 2013
...Olli Silvennoinen; Daniela Ungureanu; Yashavanthi Niranjan; Henrik Hammaren; Rajintha Bandaranayake; Stevan R. Hubbard JAK (Janus kinase) 2 plays a critical role in signal transduction through several cytokine receptors. JAKs contain a typical tyrosine kinase domain preceded by a pseudokinase [JH2...
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Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... to influence the spatiotemporal signalling of Ras. 1 Correspondence may be addressed to either of these authors (email iprior@liverpool.ac.uk or henis@post.tau.ac.il ). 15 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 compartmentalization nanocluster...
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Biochem Soc Trans (2012) 40 (6): 1512–1516.
Published: 21 November 2012
... correspondence should be addressed (email monica.abrudan@postgrad.manchester.ac.uk ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin biodiversity evolution quorum sensing signalling Recent theoretical and experimental work suggests that bacteriocins might play a key role...
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Biochem Soc Trans (2012) 40 (2): 311–323.
Published: 21 March 2012
...Alena Krejčí There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription. Central metabolic pathways are under the control of signalling pathways and, vice versa, the cellular metabolic profile influences cell signalling through...
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Biochem Soc Trans (2012) 40 (1): 257–261.
Published: 19 January 2012
... subcellular locations, and the identification of a number of PtdIns5 P -binding proteins points to its involvement in a variety of key processes, including signal transduction, membrane trafficking and regulation of gene expression. Although the mechanisms that control its turnover are not yet fully...
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Biochem Soc Trans (2012) 40 (1): 67–72.
Published: 19 January 2012
...Catherine Andreadi; Catherine Noble; Bipin Patel; Hong Jin; Maria M. Aguilar Hernandez; Kathryn Balmanno; Simon J. Cook; Catrin Pritchard The strength and duration of intracellular signalling pathway activation is a key determinant of the biological outcome of cells in response to extracellular...
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Biochem Soc Trans (2012) 40 (1): 200–204.
Published: 19 January 2012
...Patricia Moussatche; Thomas J. Lyons The steroid hormone progesterone regulates many critical aspects of vertebrate physiology. The nuclear receptor for progesterone functions as a ligand-activated transcription factor, directly regulating gene expression. This type of signalling is referred...
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Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
... the first clue for specificity of signalling in endothelial cell activation, understanding the integrative response that drives angiogenesis requires a much broader perspective. The Advances in the Cellular and Molecular Biology of Angiogenesis meeting brought together researchers at the forefront...
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Biochem Soc Trans (2011) 39 (2): 431–436.
Published: 22 March 2011
..., an antibiotic and immunosuppressant, inhibits functions of TORC1. Use of this drug has revealed roles for TORC1 and its mammalian counterpart, mTORC1, in promoting many anabolic processes. mTORC1 signalling is activated by growth factors and nutrients. It is highly active in many cancers and plays a role...