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Keywords: sirtuins
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Articles
Biochem Soc Trans (2021) 49 (6): 2807–2819.
Published: 23 November 2021
.... In particular, we will examine the roles of NAD + dependant sirtuin deacetylases, which mediate mitochondrial acetylation, and how this post-translational modification provides an exquisite regulatory mechanism to co-ordinate mitochondrial function with metabolic demands of the cell. A key aspect...
Articles
Biochem Soc Trans (2020) 48 (3): 733–744.
Published: 23 June 2020
... glycolysis and mitochondrial respiration to support cell growth and survival. In addition, many key enzymes that regulate diverse cell functions ranging from gene expression to proteostasis require NAD + as a co-substrate for their catalytic activity. This includes the NAD + -dependent sirtuin family...
Articles
Biochem Soc Trans (2019) 47 (1): 119–130.
Published: 09 January 2019
... in the regulation of a multitude of fundamental cellular processes. This includes DNA repair, cell cycle regulation, gene expression and calcium signalling, in which NAD is a substrate for several families of regulatory proteins, such as sirtuins and ADP-ribosyltransferases. At the molecular level, NAD-dependent...
Articles
Biochem Soc Trans (2015) 43 (6): 1127–1132.
Published: 27 November 2015
... does not hold true in general. NAD-consuming reactions are common characteristics of NAD + -dependent signalling pathways and include mono- and poly-ADP-ribosylation of proteins, NAD + -dependent deacetylation by sirtuins and the formation of messenger molecules such as cyclic ADP-ribose (cADPR...