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Keywords: small molecule BMP inhibitors
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Biochem Soc Trans (2016) 44 (4): 1117–1134.
Published: 15 August 2016
... to its receptor. Smurf1/2 and SMAD6/7 can prevent phosphorylation of SMAD1/5/8 and binding to its co-factor SMAD4. Small molecule BMP inhibitors, such as dorsomorphin (DM) and DMH1, are competitive kinase inhibitors of BMP type I receptor. Inside the green insert are the non-canonical (SMAD-independent...