...Dunja Aksentijevic; Brett A. O'Brien; Thomas R. Eykyn; Michael J. Shattock Alterations in excitation–contraction coupling and elevated intracellular sodium (Na i ) are hallmarks of pathological cardiac remodelling that underline contractile dysfunction. In addition, changes in cardiac metabolism...

... lyase transcriptional activator) domains that bind cyclic nucleotides. Similarly, the CyaB1 and CyaB2 ACs (adenylate cyclases) of the cyanobacterium Anabaena PCC 7120 bind cAMP through one (CyaB1) or two (CyaB2) N-terminal GAF domains and mediate autoregulation of the AC domain. Sodium inhibits...