... to their conformational plasticity RNA pose a challenge for mainstream structural biology methods. Solid-state NMR (ssNMR) spectroscopy is an emerging technique that can be applied to biomolecular complexes of any size in close-to-native conditions. This review outlines recent methodological developments in ssNMR...

... for revolutionizing biomolecular and biomaterial research. Importance of the field : MAS-DNP has vastly broadened the horizon of solid-state NMR spectroscopy and enabled the atomic-level view of polymorphic biomolecules in their native cellular environments. The structural insights of protein machinery...

... © The Authors Journal compilation © 2012 Biochemical Society 2012 G-protein-coupled receptor (GPCR) retinal chromophore rhodopsin solid-state NMR transmembrane helix vision Rhodopsin is the visual pigment responsible for dim-light photoreception in vertebrates [ 1 – 3...

...D.A. Middleton Structure-based design has gained credibility as a valuable component of the modern drug discovery process. The technique of SSNMR (solid-state NMR) promises to be a useful counterpart to the conventional experimental techniques of X-ray crystallography and solution-state NMR...

...C. Ader; R. Schneider; K. Seidel; M. Etzkorn; M. Baldus ssNMR (solid-state NMR) spectroscopy provides increasing possibilities to study the structural and dynamic aspects of biological membranes. Here, we review recent ssNMR experiments that are based on MAS (magic angle spinning) and that provide...

... (surface plasmon resonance) approach, as well as by conventional radioligand binding measurements. These improvements in production of NTS1 now open up the possibility of direct structural studies, such as solid-state NMR to interrogate the NT-binding site, EM (electron microscopy), and X-ray...