... in the sperm head. Generally, screening for overall DNA damage is relatively commonplace in clinics, but aneuploidy assessment is less so and nuclear organisation studies form the basis of academic research. Several studies have focussed on the role of chromosome segregation, nuclear organisation and analysis...

...Karl Swann; F. Anthony Lai A series of intracellular oscillations in the free cytosolic Ca 2+ concentration is responsible for activating mammalian eggs at fertilization, thus initiating embryo development. It has been proposed that the sperm causes these Ca 2+ oscillations after membrane fusion...

...Michail Nomikos Egg activation is the first step of embryonic development and in mammals is triggered by a series of cytoplasmic calcium (Ca 2+ ) oscillations. Sperm–egg fusion initiates these Ca 2+ oscillations by introducing a sperm-specific protein factor into the egg cytoplasm. Substantial...

...Michael Jakob Clausen; Poul Nissen; Hanne Poulsen The sole purpose of a sperm cell is to carry genetic information from a male to a female egg. In order to accomplish this quest, the sperm cell must travel a long distance through a constantly changing environment. The success of this journey...

... +/+ homozygotes born from Kit tm1Alf /+ heterozygotes maintain and transmit to their progeny the white-spotted phenotype characteristic of the mutant heterozygote. Our observation of unusual amounts of RNA in the sperm of the paramutated ( Kit *) males had led us to consider the possibility of RNA-mediated...

...G. Halet; P. Marangos; G. FitzHarris; J. Carroll The mouse egg provided the first direct measurement of Ca 2+ oscillations in any cell type. These sperm-induced Ca 2+ oscillations occur at a relatively low frequency, and can be detected up to 18–20 h after sperm–egg fusion. The Ca 2+ oscillations...