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Biochem Soc Trans (2021) 49 (1): 107–118.
Published: 15 January 2021
... of the egg. Chromosome segregation is driven by a microtubule spindle, which captures and separates the paired chromosomes during meiosis I, and sister chromatids during meiosis II. Recent studies reveal that defects in the organization of the acentrosomal meiotic spindle contribute to human egg aneuploidy...
Biochem Soc Trans (2015) 43 (1): 7–12.
Published: 26 January 2015
...Lesley N. Weaver; Claire E. Walczak The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding...
Biochem Soc Trans (2013) 41 (6): 1761–1765.
Published: 20 November 2013
...John C. Meadows Correct transmission of genetic information from mother to daughter cells is necessary for development and survival. Accurate segregation is achieved by bipolar attachment of sister kinetochores in each chromatid pair to spindle microtubules emanating from opposite spindle poles...
Biochem Soc Trans (2011) 39 (5): 1154–1160.
Published: 21 September 2011
...David Vanneste; Vanessa Ferreira; Isabelle Vernos The bipolar spindle is a highly dynamic structure that assembles transiently around the chromosomes and provides the mechanical support and the forces required for chromosome segregation. Spindle assembly and chromosome movements rely...
Biochem Soc Trans (2009) 37 (5): 971–975.
Published: 21 September 2009
... of birth defects and the most common genetic alteration among solid tumours. This inspired the hypothesis that aneuploidy could be a contributing factor in carcinogenesis (reviewed in [ 5 ]). Attachment of chromosomes to spindle microtubules, a prerequisite for biorientation, is monitored by a cell-cycle...
Biochem Soc Trans (2006) 34 (5): 711–715.
Published: 25 October 2006
...M. Dasso The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear...
Biochem Soc Trans (2006) 34 (5): 716–721.
Published: 25 October 2006
...B. Goodman; Y. Zheng Assembly and disassembly of the mitotic spindle are essential for both chromosome segregation and cell division. The small G-protein Ran has emerged as an important regulator of spindle assembly. In this review, we look at the role of Ran in different aspects of spindle...