... for mitochondria make up a significant portion of all proteins produced in the cytosol. Therefore, import defects causing their mislocalization can significantly stress cellular protein homeostasis. Recognition of this phenomenon has increased interest in molecular mechanisms that respond to import-related stress...

... and function of synapses. Several lines of data in mice show that LRRK2-G2019S, the most common LRRK2 mutation, produces an abnormal gain of pathological function that affects synaptic activity, spine morphology, persistent forms of synapse plasticity and behavioral responses to social stress. Effects...

... physiological and pathological processes has become widely recognized; these include redox signalling and redox homoeostasis, drug metabolism and disposition, intermediary metabolism, cellular adaptation to stress, chemoprevention and chemoresistance, toxicity, inflammation, neurodegeneration, lipogenesis...

... pantetheinase in situations of increased tissue needs and propose that Vnn1 through recycling of pantothenate and release of cysteamine in tissues participates in the adaptive response of the tissue to stress. 1 Correspondence may be addressed to either of these authors (email [email protected]...

...Clare E. Simpson; Mark P. Ashe For most eukaryotic organisms, including Saccharomyces cerevisiae , the rapid inhibition of protein synthesis forms part of a response to stress. In order to balance the changing conditions, precise stress-specific alterations to the cell's proteome are required...

... compilation © 2011 Biochemical Society 2011 bioprocess control recombinant membrane protein production ribosome biogenesis stress yeast Membrane proteins are central to many cellular processes: they are involved in the uptake and export of diverse charged and uncharged molecules, as well...

... with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance. 1 Correspondence...

...Allan G. Rasmusson; Sabá V. Wallström NADPH and NADH mediate reductant flow between cellular processes, linking central carbon and energy metabolism with intermediary metabolism, stress defence and development. Recent investigations have revealed paths of functional interactions, and have suggested...

...Megan Cully; Julian Downward Cellular stresses can induce a wide range of biological responses, depending on the type of stress, the type of cell and the cellular environment. Stress-mediated changes in translational output cover a broad spectrum of potential responses, including an overall...

... that SUMO (small ubiquitin-related modifier) conjugation/deconjugation equilibrium is affected by various environmental stresses, including osmotic, hypoxic, heat, oxidative and genotoxic stresses. This regulation occurs either at the level of individual targets, through an interplay between stress-induced...

... are being assigned to a plethora of phosphorylated derivatives of inositol and phosphatidylinositol. Two such examples are discussed briefly: the activation by environmental stresses of the single phosphoinositidase C of yeast, which is related to the phospholipase C δs of other eukaryotes...

... be addressed (e-mail [email protected] ) 26 6 2000 © 2000 Biochemical Society 2000 Capsicum annuum fatty acid glycerolipid stress MGDG, monogalactosyldiacylglycerol DGDG, digalactosyldiacylglycerol PC, phosphatidylcholine TBA-rm, 2-thiobarbituric acid-reactive material...