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Keyword: stress granule
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Articles
Biochem Soc Trans (2015) 43 (6): 1277-1284.
Published: 27 November 2015
...) stress granule Eukaryotic cells rely on post-transcriptional control of gene expression to ensure the tight spatiotemporal control of protein production needed to fulfil their functions. One key feature of eukaryotic mRNAs is the co-transcriptionally added 3’-poly(A) tail which is important for...
Articles
Biochem Soc Trans (2014) 42 (4): 1256-1260.
Published: 11 August 2014
... associated with translational repression or activation. Furthermore, mRNA P-bodies (processing bodies) harbour much of the mRNA decay machinery and stress granules are thought to play a role in mRNA storage. In the present review, we explore the process of mRNA localization in the yeast Saccharomyces...
Articles
Biochem Soc Trans (2014) 42 (4): 1206-1210.
Published: 11 August 2014
...Dipen Rajgor; Catherine M. Shanahan In eukaryotic cells, non-translating mRNAs can accumulate into cytoplasmic mRNP (messenger ribonucleoprotein) granules such as P-bodies (processing bodies) and SGs (stress granules). P-bodies contain the mRNA decay and translational repression machineries and are...
Articles
Biochem Soc Trans (2010) 38 (6): 1537-1542.
Published: 24 November 2010
... translational level. More recently, we have shown that in cells overexpressing P-glycoprotein, MDR1 mRNA does not aggregate into translationally silent stress granules. Importantly, this is not unique for MDR1 , since other transcripts encoding transmembrane proteins, and which are thus translated at the...
Articles
Biochem Soc Trans (2010) 38 (4): 1131-1136.
Published: 26 July 2010
... body (P-body) stress granule translation control Nutrient signalling is intrinsically linked to cellular growth and the ability to sense fluctuations in nutrient levels allows cells to adapt to changing environments to ensure cell survival. Glucose is the most abundant monosaccharide in...
Articles
Biochem Soc Trans (2008) 36 (4): 648-652.
Published: 22 July 2008
... mark.p.ashe@manchester.ac.uk ). 10 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 EGP-body eukaryotic initiation factor (eIF) mRNA processing body (P-body) stress granule translation initiation In eukaryotic cells, the broad restriction of genetic...
Articles
Biochem Soc Trans (2008) 36 (4): 671-676.
Published: 22 July 2008
... cytoplasmic polyadenylation element-binding protein (CPEB) processing body (P-body) RNA decay stress granule translation initiation Regulation of gene expression at the level of translation is an important level of control in eukaryotes and is essential in early development and in neurons, in the...
Articles
Biochem Soc Trans (2008) 36 (3): 491-496.
Published: 21 May 2008
...-rich element cytokine mRNA degradation processing body stress granule tristetraprolin The role of TTP was uncovered by the careful analysis of TTP-knockout mice, which develop generalized inflammation characterized by cachexia, spontaneous arthritis, dermatitis and neutrophilia [ 1 ]. The...
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Articles
Biochem Soc Trans (2008) 36 (3): 534-536.
Published: 21 May 2008
... adenosine deaminase that acts on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation The role of dsRNA (double-stranded RNA) in cells has been the subject of much recent research following the finding that it is an essential component of the RNAi (RNA...
Articles
Biochem Soc Trans (2002) 30 (6): 963-969.
Published: 01 November 2002
...N. Kedersha; P. Anderson Mammalian stress granules (SGs) are cytoplasmic domains into which mRNAs are sorted dynamically in response to phosphorylation of eukaryotic initiation factor (eIF) 2α, a key regulatory step in translational initiation. The activation of one or more of the eIF2α kinases...