...J. Monty Watkins; James M. Burke Several biomolecular condensates assemble in mammalian cells in response to viral infection. The most studied of these are stress granules (SGs), which have been proposed to promote antiviral innate immune signaling pathways, including the RLR-MAVS, the protein...

...Noah S. Helton; Stephanie L. Moon Maintenance of proteostasis is of utmost importance to cellular viability and relies on the coordination of many post-transcriptional processes to respond to stressful stimuli. Stress granules (SGs) are RNA–protein condensates that form after translation initiation...

... for the cellular response to toxic injury. As part of the stress-induced inhibition of translation, mRNAs encoding non-essential housekeeping proteins are redirected from polysomes to stress granules (SGs) or processing bodies (P-bodies). These translationally inactive, membraneless cytoplasmic foci allow...

... localisation, but they mainly incorporate proteins and RNA. Examples of these ribonucleoprotein bodies (RNPBs) include eukaryotic mRNA processing bodies (P-bodies) and stress granules (SGs). While most of these structures have been widely studied for their capacity to bind, store and process mRNAs under...