... paraspeckle stress response TDP-43 Earlier findings on the contribution of TDP-43 self-association to its splicing competency were contradictory. TDP-43 autoregulation or target gene splicing were found to be compromised by NTD or CTD mutations impacting phase separation in some reports [ 43...

... in translation regulation beyond initiation have only begun to be elucidated. Methodological advances enabled critical discoveries on the control of translation elongation, highlighting its important role in translation repression and the synthesis of stress-response proteins. In this article, we discuss recent...

... dysfunction Parkinson's disease stress response CHCHD2 gene expression correlates closely with OXPHOS genes, suggesting that CHCHD2 expression may be scaled to the OXPHOS capacity of cells and tissues [ 35 ]. This may explain why CHCHD2 transcription has been associated with cancer...

... 16 2 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 gametogenesis HSF1 insulin/IGF-1 signaling proteostasis stress response Proteostasis refers to the cellular state in which proteins are properly synthesized, folded...

... was the discovery of a protein homeostasis mechanism driven by unassembled ribosomal proteins, referred to as the Ribosome Assembly Stress Response (RASTR), that controls RPG transcription through the reversible condensation of Ifh1. Correspondence: David Shore ( [email protected] ) or Benjamin Albert...

... to this domain likely affects several functions of this protein [ 13 ]. References 1 Deussing , J.M. and Chen , A. ( 2018 ) The corticotropin-releasing factor family: physiology of the stress response . Physiol. Rev. 98 , 2225 – 2286 10.1152/physrev.00042.2017 2 Cole , S.W...

... at the endoplasmic reticulum (ER), with its catalytic domain facing the ER lumen; here, ARTC1 can ADP-ribosylate GRP78/Bip, a protein involved in protein folding and ER stress response [ 43 ], resulting in its transient inactivation [ 44 , 45 ]. Despite these examples, the substrates of the different ARTCs, as well...

... granules stress response translation translational reprogramming Following exposure to a wide range of toxic agents, several gene regulation programmes are initiated to orchestrate the appropriate cellular response. An essential part of the cell stress response occurs post-transcriptionally...

... target recognition. Expression of many sRNAs is positively regulated by stress-responsive sigma factors like RpoE and RpoS, and two-component systems like PhoP/Q, Cpx and Rcs. Some of these regulatory RNAs act via a feedback mechanism on their own regulators, which is best reflected by recent discoveries...

... such as optineurin and NDP52 ( Figure 1 ). autophagy degradation mitochondria stress response Mitochondria perform a variety of essential physiological functions in all eukaryotic cells. The production of ATP by oxidative phosphorylation is clearly the best publicized of these roles. However, no less...

... by Portland Press Limited 2015 antioxidant response element hazard assessment Kelch-like ECH-associated protein 1 (Keap1) nuclear factor erythroid 2-related factor 2 (Nrf2) stress response toxicity The process of evolution has enabled mammalian cells to withstand continuous exposure...

... stress response vascular endothelial growth factor (VEGF) Angiogenesis inhibition has generated positive results in clinical trials in colon, kidney, lung and breast cancer. The discovery of a link between the VHL (von Hippel–Lindau) tumour-suppressor gene, HIF-1 (hypoxia-inducible factor 1...

... the expression of stress-responsive genes so that the Bacillus can survive the imposition of stress. Hence the stressosome acts as a hub, receiving manifold different stimuli to effect a single outcome. Using single-particle analysis of cryo-electron micrographs, we have been able to reconstruct a series...

... are microbial stress-response elements, although it was recently shown that knocking out all known chromosomally located TA loci in Escherichia coli did not have an impact on survival under certain types of stress. The hyperthermophilic crenarchaeon Sulfolobus solfataricus encodes at least 26 vapBC (where vap...

... of the genes induced by eIF2 phosphorylation are shared between different environmental stresses, eIF2 kinases function in conjunction with other stress-response pathways, such as those regulated by mitogen-activated protein kinases, to elicit gene expression programmes that are tailored for the specific...