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Articles

Understanding P-Rex regulation: structural breakthroughs and emerging perspectives

Gareth D. Jones, Andrew M. Ellisdon

Biochem Soc Trans (2024) 52 (4): 1849–1860.

https://doi.org/10.1042/BST20231546

Published: 18 July 2024

... and the Biochemical Society under a transformative agreement with CAUL. G-proteins GTPases guanine nucleotide exchange factor phosphatidylinositol Rac structural biology Correspondence: Andrew M. Ellisdon ( [email protected] ) 28 5 2024 2 7 2024 8 7 2024...

View articletitled, Understanding P-Rex regulation: structural breakthroughs and emerging perspectives

Articles

Structural insights into ferroportin mediated iron transport

Mika Jormakka

Biochem Soc Trans (2023) 51 (6): 2143–2152.

https://doi.org/10.1042/BST20230594

Published: 20 December 2023

... 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 iron metabolism membrane proteins structural biology transport Recently the BbFpn structures have been complemented by structures of human (HsFpn) and primate (TsFpn) proteins...

View articletitled, Structural insights into ferroportin mediated iron transport

Articles

The molecular mechanisms of human separase regulation

Jun Yu, David O. Morgan, Andreas Boland

Biochem Soc Trans (2023) 51 (3): 1225–1233.

https://doi.org/10.1042/BST20221400

Published: 04 May 2023

...–substrate interactions inhibition structural biology AIL2 is spatially closer positioned to the N-terminus of separase than AIL1 ( Figure 1b ) and blocks access to a hydrophobic channel near patch II in the TPR-like domain; this channel is occupied by a hydrophobic segment of securin in the securin...

View articletitled, The molecular mechanisms of human separase regulation

Articles

The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder

Katerina Cermakova, Vaclav Veverka, H. Courtney Hodges

Biochem Soc Trans (2023) 51 (1): 125–135.

https://doi.org/10.1042/BST20220342

Published: 18 January 2023

...(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . intrinsically disordered proteins molecular scaffolds structural biology transcription...

View articletitled, The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder

Articles

Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits

Joshua M. Hardy, Rhys A. Dunstan, Trevor Lithgow, Fasséli Coulibaly

Biochem Soc Trans (2022) 50 (1): 459–22W.

https://doi.org/10.1042/BST20210799

Published: 07 February 2022

..., (iii) sufficient potential energy stored in the packaging of the genomic DNA to drive the passage of the phage genomic DNA through the tail tube and into the cytoplasm. bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages...

View articletitled, Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits

Articles

Mechanism of action of nucleotide excision repair machinery

Areetha D'Souza, Alexandra M. Blee, Walter J. Chazin

Biochem Soc Trans (2022) 50 (1): 375–386.

https://doi.org/10.1042/BST20210246

Published: 25 January 2022

... ( [email protected] ) 4 11 2021 20 12 2021 22 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 DNA synthesis and repair nucleotide excision repair structural biology Removal of the damaged DNA depends...

View articletitled, Mechanism of action of nucleotide excision repair machinery

Articles

MsbA: an ABC transporter paradigm

Christian Bonifer, Clemens Glaubitz

Biochem Soc Trans (2021) 49 (6): 2917–2927.

https://doi.org/10.1042/BST20211030

Published: 25 November 2021

... spectroscopy NMR spectroscopy structural biology The superfamily of ABC transporters contains a variety of proteins from all domains of life that fulfil a multitude of functions in cellular processes. Defects in ABC transporters are connected to diseases such as cystic fibrosis [ 1 ], while fully...

View articletitled, MsbA: an ABC transporter paradigm

Articles

Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity

Benjamin S. Gully, Jamie Rossjohn, Martin S. Davey

Biochem Soc Trans (2021) 49 (5): 1985–1995.

https://doi.org/10.1042/BST20200890

Published: 13 September 2021

... Society under a transformative agreement with CAUL. immunology structural biology T-cells The human adaptive immune system has conserved a tripartite lymphocyte compartment comprising B cells, αβ and γδ T cells for over 450 million years of vertebrate evolution [ 1 ]. Whilst great strides...

View articletitled, Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity

Articles

Protein–membrane interactions in small GTPase signalling and pharmacology: perspectives from Arf GTPases studies

Agata Nawrotek, Mahel Zeghouf, Jacqueline Cherfils

Biochem Soc Trans (2020) 48 (6): 2721–2728.

https://doi.org/10.1042/BST20200482

Published: 18 December 2020

... Cherfils ( [email protected] ) 9 10 2020 12 11 2020 13 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 membranes small gtpases small molecules structural biology trafficking...

View articletitled, Protein–membrane interactions in small GTPase signalling and pharmacology: perspectives from Arf GTPases studies

Articles

A pocket guide on how to structure SARS-CoV-2 drugs and therapies

Dene R. Littler, Bruce J. MacLachlan, Gabrielle M. Watson, Julian P. Vivian, Benjamin S. Gully

Biochem Soc Trans (2020) 48 (6): 2625–2641.

https://doi.org/10.1042/BST20200396

Published: 01 December 2020

... numerous vaccination and clinical trials have emerged alongside an innumerable number of drug discovery studies currently in development for disease intervention. Informing every step of the viral replication cycle has been an unprecedented ‘call-to-arms' by the global structural biology community...

View articletitled, A pocket guide on how to structure SARS-CoV-2 drugs and therapies

Articles

Membrane protein crystallography in the era of modern structural biology

Tristan O. C. Kwan, Danny Axford, Isabel Moraes

Biochem Soc Trans (2020) 48 (6): 2505–2524.

https://doi.org/10.1042/BST20200066

Published: 10 November 2020

...Tristan O. C. Kwan; Danny Axford; Isabel Moraes The aim of structural biology has been always the study of biological macromolecules structures and their mechanistic behaviour at molecular level. To achieve its goal, multiple biophysical methods and approaches have become part of the structural...

View articletitled, Membrane protein crystallography in the era of modern structural biology

Articles

Condensin complexes: understanding loop extrusion one conformational change at a time

Erin E. Cutts, Alessandro Vannini

Biochem Soc Trans (2020) 48 (5): 2089–2100.

https://doi.org/10.1042/BST20200241

Published: 02 October 2020

... structural biology Organising DNA throughout the cell cycle to ensure correct gene expression, DNA replication, and chromosome division is a remarkable feat. Two structural maintenance of chromosomes complexes (SMCs), condensin and cohesin, contribute greatly to this process [ 1 ]. Accordingly...

View articletitled, Condensin complexes: understanding loop extrusion one conformational change at a time

Articles

The road to the structure of the mitochondrial respiratory chain supercomplex

Nikeisha J. Caruana, David A. Stroud

Biochem Soc Trans (2020) 48 (2): 621–629.

https://doi.org/10.1042/BST20190930

Published: 20 April 2020

... for interpreting our own functional data, we need to remind ourselves that they stand on the shoulders of a large body of previous structural studies, many of which are still appropriate for use in understanding our results. In this mini-review, we discuss the history of respiratory chain structural biology...

View articletitled, The road to the structure of the mitochondrial respiratory chain supercomplex

Articles

Diversity of molecular mechanisms used by anti-CRISPR proteins: the tip of an iceberg?

Pierre Hardouin, Adeline Goulet

Biochem Soc Trans (2020) 48 (2): 507–516.

https://doi.org/10.1042/BST20190638

Published: 20 March 2020

...-CRISPR proteins molecular interactions molecular mechanisms structural biology In the battle for survival, bacteria and archaea have evolved mechanistically diverse defense mechanisms to resist their predators [ 1 ]. The prokaryotic CRISPR–Cas immune system uniquely provides a memory of past...

View articletitled, Diversity of molecular mechanisms used by anti-CRISPR proteins: the tip of an iceberg?

Articles

Better together: building protein oligomers naturally and by design

Rebecca E.A. Gwyther, D. Dafydd Jones, Harley L. Worthy

Biochem Soc Trans (2019) 47 (6): 1773–1780.

https://doi.org/10.1042/BST20190283

Published: 05 December 2019

... representing the most commonly observed form in the Protein Databank [ 1 , 2 ]. expanded genetic code oligomerization protein complexes protein engineering structural biology synthetic biology © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019...

View articletitled, Better together: building protein oligomers naturally and by design

Articles

ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion

Aiman A. Zein, Rupinder Kaur, Toka O.K. Hussein, Gregory A. Graf, Jyh-Yeuan Lee

Biochem Soc Trans (2019) 47 (5): 1259–1268.

https://doi.org/10.1042/BST20190130

Published: 18 October 2019

... and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ATP-binding cassette transporters cardiovascular disease cholesterol transport lipid metabolism sitosterolemia structural biology ABCG5 and ABCG8 genes are situated head-to-head on opposite strands...

View articletitled, ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion

Articles

Twenty years of Mediator complex structural studies

Alexis Verger, Didier Monté, Vincent Villeret

Biochem Soc Trans (2019) 47 (1): 399–410.

https://doi.org/10.1042/BST20180608

Published: 07 February 2019

... the Creative Commons Attribution License 4.0 (CC BY) . Cryo-EM Mediator complex structural biology transcription The Mediator complex was initially identified in yeast in the early 1990s independently by the Kornberg and the Young laboratories. The Kornberg laboratory isolated Mediator...

View articletitled, Twenty years of Mediator complex structural studies

Includes: Supplementary data

Articles

Cryo-EM in drug discovery

In Collection

Awards

Tom Ceska, Chun-Wa Chung, Rob Cooke, Chris Phillips, Pamela A. Williams

Biochem Soc Trans (2019) 47 (1): 281–293.

https://doi.org/10.1042/BST20180267

Published: 15 January 2019

...Tom Ceska; Chun-Wa Chung; Rob Cooke; Chris Phillips; Pamela A. Williams The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including...

View articletitled, Cryo-EM in drug discovery

Articles

Structural mass spectrometry comes of age: new insight into protein structure, function and interactions

In Collection

Protein structure and function

Timothy M. Allison, Cherine Bechara

Biochem Soc Trans (2019) 47 (1): 317–327.

https://doi.org/10.1042/BST20180356

Published: 15 January 2019

.... mass spectrometry membrane proteins proteomics structural biology Mass spectrometry (MS) has evolved in recent years to become a pillar for integrative structural biology approaches. Structural MS provides a plethora of information, from protein primary structure and post-translational...

View articletitled, Structural mass spectrometry comes of age: new insight into protein structure, function and interactions

Articles

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

Brendan Farrell, Alexander L. Breeze

Biochem Soc Trans (2018) 46 (6): 1753–1770.

https://doi.org/10.1042/BST20180004

Published: 13 December 2018

...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases structural biology...

View articletitled, Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

Articles

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies

Jack Wright, Stephen P. Muench, Adrian Goldman, Alison Baker

Biochem Soc Trans (2018) 46 (6): 1475–1484.

https://doi.org/10.1042/BST20180146

Published: 04 December 2018

... structural biology ABC transporters are characterised by a common domain structure consisting of two transmembrane domains (TMDs), each consisting of multiple transmembrane α-helices, followed by two nucleotide-binding domains (NBDs) that extend into the cytosol ( Figure 1 ). The TMDs and NBDs...

View articletitled, Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies

Articles

Membrane protein nanoparticles: the shape of things to come

Kailene S. Simon, Naomi L. Pollock, Sarah C. Lee

Biochem Soc Trans (2018) 46 (6): 1495–1504.

https://doi.org/10.1042/BST20180139

Published: 21 November 2018

... © 2018 The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . membrane proteins protein purification structural biology structural...

View articletitled, Membrane protein nanoparticles: the shape of things to come

Articles

Membrane protein engineering to the rescue

Andrea E. Rawlings

Biochem Soc Trans (2018) 46 (6): 1541–1549.

https://doi.org/10.1042/BST20180140

Published: 31 October 2018

... structural biology transmembrane proteins Proteins tend to be classified into one of two broad categories, globular cytoplasmic proteins and integral membrane proteins (IMPs) [ 1 ]. This simple classification is defined by a proteins intrinsic ability to produce a stable, functional structure...

View articletitled, Membrane protein engineering to the rescue

Articles

Protein structure and computational drug discovery

Tracy L. Nero, Michael W. Parker, Craig J. Morton

Biochem Soc Trans (2018) 46 (5): 1367–1379.

https://doi.org/10.1042/BST20180202

Published: 21 September 2018

... biochemistry drug discovery and design structural biology Computational methods of drug discovery have a basis in the very earliest structural studies of protein molecules. The first structure of a protein, that of sperm whale myoglobin initially at 6 Å resolution [ 1 ] then refined to 2 Å resolution...

View articletitled, Protein structure and computational drug discovery

Articles

Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors

Tamako Nishimura, Nobuhiro Morone, Shiro Suetsugu

Biochem Soc Trans (2018) 46 (2): 379–389.

https://doi.org/10.1042/BST20170322

Published: 14 March 2018

... lipid-binding domains lipids membranes microfilaments structural biology Lipid membranes determine the shape of the cell surface and organelles. The lipid membrane is a bilayer consisting of phospholipids, sphingolipids, and cholesterol in various proportion [ 1 ]. Phospholipids...

View articletitled, Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors

Articles

Overcoming bottlenecks in the membrane protein structural biology pipeline

David Hardy, Roslyn M. Bill, Anass Jawhari, Alice J. Rothnie

Biochem Soc Trans (2016) 44 (3): 838–844.

https://doi.org/10.1042/BST20160049

Published: 09 June 2016

... the native lipid bilayer of a membrane protein during purification and biophysical analysis. Overcoming bottlenecks in the membrane protein structural biology pipeline, primarily by maintaining protein stability, will facilitate the elucidation of many more membrane protein structures in the near future...

View articletitled, Overcoming bottlenecks in the membrane protein structural biology pipeline

Articles

Carbohydrate-active enzymes: sequences, shapes, contortions and cells

Gideon J. Davies, Spencer J. Williams

Biochem Soc Trans (2016) 44 (1): 79–87.

https://doi.org/10.1042/BST20150186

Published: 09 February 2016

... Press Limited 2016 biofuels conformational analysis drug design glycobiology glycosidase structural biology Glycans are found almost everywhere, and the enzymes that synthesize, modify and degrade these complex molecules are central to human health and disease and our modern...

View articletitled, Carbohydrate-active enzymes: sequences, shapes, contortions and cells

Articles

Recent structural and mechanistic insights into protein O -GalNAc glycosylation

Ramon Hurtado-Guerrero

Biochem Soc Trans (2016) 44 (1): 61–67.

https://doi.org/10.1042/BST20150178

Published: 09 February 2016

... by Portland Press Limited 2016 GalNAc-Ts retention mechanism structural biology lectin domain flexible linker enzyme dynamics Glycosyltransferases (GTs) are an ubiquitous group of enzymes that catalyse the transfer of sugar moieties from activated donors, mostly nucleotide sugars...

View articletitled, Recent structural and mechanistic insights into protein O -GalNAc glycosylation

Articles

Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling

Helen R. Mott, Darerca Owen

Biochem Soc Trans (2014) 42 (1): 52–58.

https://doi.org/10.1042/BST20130231

Published: 23 January 2014

... to phospholipase D [ 13 ] and phospholipase Cδ1 [ 14 ], suggesting a role in lipid metabolism and membrane trafficking. GTPase NMR Ral Ral-binding protein 1 (RalBP1) Ral-interacting protein of 76 kDa (RLIP76) structural biology Although we know the structures of the recognizable domains in RLIP76...

View articletitled, Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling

Articles

Microbial hydrogen splitting in the presence of oxygen

Matthias Stein, Sandeep Kaur-Ghumaan

Biochem Soc Trans (2013) 41 (5): 1317–1324.

https://doi.org/10.1042/BST20130033

Published: 23 September 2013

... structural biology Hydrogen is one of the energy carriers of the future. The investigation of hydrogen metabolism from bacteria and archaea has a strong impact on possible scenarios for future energy supply [ 1 ]. Hydrogenases are enzymes which catalyse the reversible oxidation of molecular hydrogen...

View articletitled, Microbial hydrogen splitting in the presence of oxygen

Articles

The structural mechanisms that underpin mitotic kinase activation

Charlotte A. Dodson, Tamanna Haq, Sharon Yeoh, Andrew M. Fry, Richard Bayliss

Biochem Soc Trans (2013) 41 (4): 1037–1041.

https://doi.org/10.1042/BST20130066

Published: 18 July 2013

... should be addressed (email [email protected] ). 26 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 activation mechanism Aurora-A drug discovery Nek7 protein kinase structural biology On the basis of measurements of kinase activity and analysis...

View articletitled, The structural mechanisms that underpin mitotic kinase activation

Articles

Techniques to examine nucleotide binding by pseudokinases

Isabelle S. Lucet, Jeffrey J. Babon, James M. Murphy

Biochem Soc Trans (2013) 41 (4): 975–980.

https://doi.org/10.1042/BST20130075

Published: 18 July 2013

... correspondence should be addressed (email [email protected] ). 3 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 catalytic activity fluorescence-based assay kinase-affinity chromatography nucleotide binding pseudokinase structural biology...

View articletitled, Techniques to examine nucleotide binding by pseudokinases

Articles

Type IV secretion machinery: molecular architecture and function

Vidya Chandran

Biochem Soc Trans (2013) 41 (1): 17–28.

https://doi.org/10.1042/BST20120332

Published: 29 January 2013

... describes the best-characterized Type IVA secretion system where most of the structural biology efforts have been centred for many years revealing architectural details for various components of the T4S system. The nomenclature of genes in the archetypal A. tumefaciens VirB/D4 T4S system is the easiest...

View articletitled, Type IV secretion machinery: molecular architecture and function

Articles

The 2011 Joint Sino–U.K. Protein Symposium

Zengyi Chang, Neil Isaacs

Biochem Soc Trans (2011) 39 (5): 1311–1312.

https://doi.org/10.1042/BST0391311

Published: 21 September 2011

... of structural biology of proteins, presentations covering both historical and current research were given by a number of leading biochemists from both countries. Papers based on these talks have been prepared for this issue of Biochemical Society Transactions . 1 Correspondence may be addressed to either...

View articletitled, The 2011 Joint Sino–U.K. Protein Symposium

Articles

The stressosome: molecular architecture of a signalling hub

Jon Marles-Wright, Richard J. Lewis

Biochem Soc Trans (2010) 38 (4): 928–933.

https://doi.org/10.1042/BST0380928

Published: 26 July 2010

... Journal compilation © 2010 Biochemical Society 2010 Bacillus subtilis kinase signal transduction stressosome stress response structural biology The established model of Gram-positive micro-organisms is the soil-dwelling rod-shaped Bacillus subtilis . This organism has long been...

View articletitled, The stressosome: molecular architecture of a signalling hub

Articles

Crystallography and protein–protein interactions: biological interfaces and crystal contacts

Bostjan Kobe, Gregor Guncar, Rebecca Buchholz, Thomas Huber, Bohumil Maco, Nathan Cowieson, Jennifer L. Martin, Mary Marfori, Jade K. Forwood

Biochem Soc Trans (2008) 36 (6): 1438–1441.

https://doi.org/10.1042/BST0361438

Published: 19 November 2008

... Society 2008 acyl-CoA thioesterase 7 (Acot7) platelet glycoprotein Ibα protein–protein interaction structural biology thrombin X-ray crystallography The growth in combining other techniques with the traditional approaches of MX, NMR and EM (electron microscopy) shows both the benefits...

View articletitled, Crystallography and protein–protein interactions: biological interfaces and crystal contacts

Articles

The emerging role of MS in structure elucidation of protein–nucleic acid complexes

Yuliya Gordiyenko, Carol V. Robinson

Biochem Soc Trans (2008) 36 (4): 723–731.

https://doi.org/10.1042/BST0360723

Published: 22 July 2008

... topological arrangements of subunits and interactions within RNA–protein complexes studied in our laboratory over the last 5 years. These studies exemplify the emerging role and potential of MS as a complementary structural biology methodology and demonstrate its unique niche in investigations of dynamic...

View articletitled, The emerging role of MS in structure elucidation of protein–nucleic acid complexes

Articles

The structural biology of voltage-gated calcium channel function and regulation

F. Van Petegem, D.L. Minor, Jr

Biochem Soc Trans (2006) 34 (5): 887–893.

https://doi.org/10.1042/BST0340887

Published: 25 October 2006

...-dependent inactivation (CDI) calmodulin (CaM) IQ domain structural biology voltage-gated calcium channel (Ca V ) Voltage-gated calcium channels (Ca V s) play a unique role in the interplay between electrical and chemical signalling in biological systems [ 1 , 2 ]. Ca V s respond to membrane...

View articletitled, The structural biology of voltage-gated calcium channel function and regulation

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