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Keywords: structural biology
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Articles
Biochem Soc Trans (2021) BST20200890.
Published: 13 September 2021
... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. immunology structural biology T-cells The human adaptive immune system has conserved a tripartite lymphocyte compartment comprising B cells, αβ and γδ T cells for over...
Articles
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 membranes small gtpases small molecules structural biology trafficking Cytoplasmic small GTPases and most of their interacting proteins belong to the broad class of peripheral membrane proteins, which...
Articles
Biochem Soc Trans (2020) 48 (6): 2625–2641.
Published: 01 December 2020
... numerous vaccination and clinical trials have emerged alongside an innumerable number of drug discovery studies currently in development for disease intervention. Informing every step of the viral replication cycle has been an unprecedented ‘call-to-arms' by the global structural biology community...
Articles
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
...Tristan O. C. Kwan; Danny Axford; Isabel Moraes The aim of structural biology has been always the study of biological macromolecules structures and their mechanistic behaviour at molecular level. To achieve its goal, multiple biophysical methods and approaches have become part of the structural...
Articles
Biochem Soc Trans (2020) 48 (5): 2089–2100.
Published: 02 October 2020
... under the Creative Commons Attribution License 4.0 (CC BY) . chromosomes condensin DNA binding single-molecule SMC structural biology Organising DNA throughout the cell cycle to ensure correct gene expression, DNA replication, and chromosome division is a remarkable feat. Two...
Articles
Biochem Soc Trans (2020) 48 (2): 621–629.
Published: 20 April 2020
... for interpreting our own functional data, we need to remind ourselves that they stand on the shoulders of a large body of previous structural studies, many of which are still appropriate for use in understanding our results. In this mini-review, we discuss the history of respiratory chain structural biology...
Articles
Biochem Soc Trans (2020) 48 (2): 507–516.
Published: 20 March 2020
... anti-CRISPR proteins molecular interactions molecular mechanisms structural biology In the battle for survival, bacteria and archaea have evolved mechanistically diverse defense mechanisms to resist their predators [ 1 ]. The prokaryotic CRISPR–Cas immune system uniquely provides a memory...
Articles
Biochem Soc Trans (2019) 47 (6): 1773–1780.
Published: 05 December 2019
... 2019 15 11 2019 18 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 expanded genetic code oligomerization protein complexes protein engineering structural biology synthetic biology The vast expanse of protein...
Articles
Biochem Soc Trans (2019) 47 (5): 1259–1268.
Published: 18 October 2019
... and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ATP-binding cassette transporters cardiovascular disease cholesterol transport lipid metabolism sitosterolemia structural biology Cardiovascular diseases are the leading cause of death globally (∼50% deaths...
Articles
Biochem Soc Trans (2019) 47 (1): 399–410.
Published: 07 February 2019
... the Creative Commons Attribution License 4.0 (CC BY) . Cryo-EM Mediator complex structural biology transcription The Mediator complex was initially identified in yeast in the early 1990s independently by the Kornberg and the Young laboratories. The Kornberg laboratory isolated Mediator...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (1): 281–293.
Published: 15 January 2019
...Tom Ceska; Chun-Wa Chung; Rob Cooke; Chris Phillips; Pamela A. Williams The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including...
Articles
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
...@canterbury.ac.nz ) or Cherine Bechara ( cherine.bechara@igf.cnrs.fr ) 13 9 2018 27 11 2018 4 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 mass spectrometry membrane proteins proteomics structural biology Mass...
Articles
Biochem Soc Trans (2018) 46 (6): 1753–1770.
Published: 13 December 2018
...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases structural biology...
Articles
Biochem Soc Trans (2018) 46 (6): 1475–1484.
Published: 04 December 2018
... if the conformation is an inward one. Finally, it is clear from the direction of the field of structural biology as a whole that the membrane and local lipid environment should be considered when investigating membrane protein function. Thus, the hypothesis that ABC transporters behave in a spring-like fashion...
Articles
Biochem Soc Trans (2018) 46 (6): 1495–1504.
Published: 21 November 2018
... opportunities for exploiting SMALPs to expand our understanding of structural and functional properties of MPs. membrane proteins protein purification structural biology structural characterisation While the first three technologies are essential for MP science, they have been thoroughly reviewed...
Articles
Biochem Soc Trans (2018) 46 (6): 1541–1549.
Published: 31 October 2018
.... Correspondence: Andrea E. Rawlings ( a.rawlings@sheffield.ac.uk ) 4 8 2018 3 9 2018 5 9 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 protein engineering structural biology transmembrane proteins Proteins tend...
Articles
Biochem Soc Trans (2018) 46 (5): 1367–1379.
Published: 21 September 2018
...: Michael W. Parker ( mwp@unimelb.edu.au ) 27 6 2018 8 8 2018 13 8 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 computational biochemistry drug discovery and design structural biology Computational methods...
Articles
Biochem Soc Trans (2018) 46 (2): 379–389.
Published: 14 March 2018
Articles
Biochem Soc Trans (2016) 44 (3): 838–844.
Published: 09 June 2016
... the native lipid bilayer of a membrane protein during purification and biophysical analysis. Overcoming bottlenecks in the membrane protein structural biology pipeline, primarily by maintaining protein stability, will facilitate the elucidation of many more membrane protein structures in the near future...
Articles
Biochem Soc Trans (2016) 44 (1): 79–87.
Published: 09 February 2016
... structural biology Glycans are found almost everywhere, and the enzymes that synthesize, modify and degrade these complex molecules are central to human health and disease and our modern industrial society. The recent rebirth of interest in this field stems from three main sources (strongly...
Articles
Biochem Soc Trans (2016) 44 (1): 61–67.
Published: 09 February 2016
... by Portland Press Limited 2016 GalNAc-Ts retention mechanism structural biology lectin domain flexible linker enzyme dynamics GalNAc-Ts contain an N-terminal catalytic domain adopting a GT-A fold and a C-terminal lectin domain with a β-trefoil fold ( Figure 1 b) [ 17 ]. These enzymes...
Articles
Biochem Soc Trans (2014) 42 (1): 52–58.
Published: 23 January 2014
... ]. GTPase NMR Ral Ral-binding protein 1 (RalBP1) Ral-interacting protein of 76 kDa (RLIP76) structural biology © The Authors Journal compilation © 2014 Biochemical Society 2014 25 9 2013 1 Correspondence may be addressed to either author (email hrm28@cam.ac.uk or do202@cam.ac.uk...
Articles
Biochem Soc Trans (2013) 41 (5): 1317–1324.
Published: 23 September 2013
... bioenergetics hydrogen conversion iron–sulfur cluster (Fe–S cluster) oxygen-tolerant hydrogenase protein structural modelling structural biology Hydrogen is one of the energy carriers of the future. The investigation of hydrogen metabolism from bacteria and archaea has a strong impact on possible...
Articles
Biochem Soc Trans (2013) 41 (4): 1037–1041.
Published: 18 July 2013
... discovery Nek7 protein kinase structural biology The eukaryotic cell cycle is tightly regulated by protein phosphorylation, which peaks during mitosis and is associated with drastic reorganization of cellular structures and protein activities [ 1 ]. These mitotic phosphorylation events are co...
Articles
Biochem Soc Trans (2013) 41 (4): 975–980.
Published: 18 July 2013
... binding pseudokinase structural biology The breadth and functional diversity of the pseudokinase family have only started to emerge. Although pseudokinases display a typical kinase fold, constructed of the ten canonical subdomains [ 1 ], subtle alterations in the constellation of amino acids...
Articles
Biochem Soc Trans (2013) 41 (1): 17–28.
Published: 29 January 2013
Articles
Biochem Soc Trans (2011) 39 (5): 1311–1312.
Published: 21 September 2011
... of structural biology of proteins, presentations covering both historical and current research were given by a number of leading biochemists from both countries. Papers based on these talks have been prepared for this issue of Biochemical Society Transactions . 1 Correspondence may be addressed to either...
Articles
Biochem Soc Trans (2010) 38 (4): 928–933.
Published: 26 July 2010
... kinase signal transduction stressosome stress response structural biology The genes encoding the central stressosome components, RsbR, RsbS and RsbT, are found adjacent on the chromosome of B. subtilis , at the 5′-end of the eight gene rsbR – rsbS – rsbT – rsbU – rsbV – rsbW – sigB – rsbX...
Articles
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... Dumas J.J. Kumar R. Seehra J. Somers W.S. Mosyak L. Crystal structure of the GpIbα–thrombin complex essential for platelet aggregation Science 2003 301 222 226 19 Sadler J.E. Structural biology: a ménage à trois in two configurations Science 2003 301 177 179...
Articles
Biochem Soc Trans (2008) 36 (4): 723–731.
Published: 22 July 2008
... topological arrangements of subunits and interactions within RNA–protein complexes studied in our laboratory over the last 5 years. These studies exemplify the emerging role and potential of MS as a complementary structural biology methodology and demonstrate its unique niche in investigations of dynamic...
Articles
Biochem Soc Trans (2006) 34 (5): 887–893.
Published: 25 October 2006
...-dependent inactivation (CDI) calmodulin (CaM) IQ domain structural biology voltage-gated calcium channel (Ca V ) Voltage-gated calcium channels (Ca V s) play a unique role in the interplay between electrical and chemical signalling in biological systems [ 1 , 2 ]. Ca V s respond to membrane...