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Keywords: structural biology
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1849–1860.
Published: 18 July 2024
... and the Biochemical Society under a transformative agreement with CAUL. G-proteins GTPases guanine nucleotide exchange factor phosphatidylinositol Rac structural biology Correspondence: Andrew M. Ellisdon ( [email protected] ) 28 5 2024 2 7 2024 8 7 2024...
Articles
Structural insights into ferroportin mediated iron transport
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (6): 2143–2152.
Published: 20 December 2023
... 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 iron metabolism membrane proteins structural biology transport Recently the BbFpn structures have been complemented by structures of human (HsFpn) and primate (TsFpn) proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1225–1233.
Published: 04 May 2023
...–substrate interactions inhibition structural biology AIL2 is spatially closer positioned to the N-terminus of separase than AIL1 ( Figure 1b ) and blocks access to a hydrophobic channel near patch II in the TPR-like domain; this channel is occupied by a hydrophobic segment of securin in the securin...
Articles
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 125–135.
Published: 18 January 2023
...(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . intrinsically disordered proteins molecular scaffolds structural biology transcription...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
..., (iii) sufficient potential energy stored in the packaging of the genomic DNA to drive the passage of the phage genomic DNA through the tail tube and into the cytoplasm. bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages...
Articles
Mechanism of action of nucleotide excision repair machinery
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 375–386.
Published: 25 January 2022
... ( [email protected] ) 4 11 2021 20 12 2021 22 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 DNA synthesis and repair nucleotide excision repair structural biology Removal of the damaged DNA depends...
Articles
MsbA: an ABC transporter paradigm
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2917–2927.
Published: 25 November 2021
... spectroscopy NMR spectroscopy structural biology The superfamily of ABC transporters contains a variety of proteins from all domains of life that fulfil a multitude of functions in cellular processes. Defects in ABC transporters are connected to diseases such as cystic fibrosis [ 1 ], while fully...
Articles
Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 1985–1995.
Published: 13 September 2021
... Society under a transformative agreement with CAUL. immunology structural biology T-cells The human adaptive immune system has conserved a tripartite lymphocyte compartment comprising B cells, αβ and γδ T cells for over 450 million years of vertebrate evolution [ 1 ]. Whilst great strides...
Articles
Protein–membrane interactions in small GTPase signalling and pharmacology: perspectives from Arf GTPases studies
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
... Cherfils ( [email protected] ) 9 10 2020 12 11 2020 13 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 membranes small gtpases small molecules structural biology trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2625–2641.
Published: 01 December 2020
... numerous vaccination and clinical trials have emerged alongside an innumerable number of drug discovery studies currently in development for disease intervention. Informing every step of the viral replication cycle has been an unprecedented ‘call-to-arms' by the global structural biology community...
Articles
Membrane protein crystallography in the era of modern structural biology
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
...Tristan O. C. Kwan; Danny Axford; Isabel Moraes The aim of structural biology has been always the study of biological macromolecules structures and their mechanistic behaviour at molecular level. To achieve its goal, multiple biophysical methods and approaches have become part of the structural...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2089–2100.
Published: 02 October 2020
... structural biology Organising DNA throughout the cell cycle to ensure correct gene expression, DNA replication, and chromosome division is a remarkable feat. Two structural maintenance of chromosomes complexes (SMCs), condensin and cohesin, contribute greatly to this process [ 1 ]. Accordingly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 621–629.
Published: 20 April 2020
... for interpreting our own functional data, we need to remind ourselves that they stand on the shoulders of a large body of previous structural studies, many of which are still appropriate for use in understanding our results. In this mini-review, we discuss the history of respiratory chain structural biology...
Articles
Diversity of molecular mechanisms used by anti-CRISPR proteins: the tip of an iceberg?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 507–516.
Published: 20 March 2020
...-CRISPR proteins molecular interactions molecular mechanisms structural biology In the battle for survival, bacteria and archaea have evolved mechanistically diverse defense mechanisms to resist their predators [ 1 ]. The prokaryotic CRISPR–Cas immune system uniquely provides a memory of past...
Articles
Better together: building protein oligomers naturally and by design
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1773–1780.
Published: 05 December 2019
... representing the most commonly observed form in the Protein Databank [ 1 , 2 ]. expanded genetic code oligomerization protein complexes protein engineering structural biology synthetic biology © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019...
Articles
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1259–1268.
Published: 18 October 2019
... and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ATP-binding cassette transporters cardiovascular disease cholesterol transport lipid metabolism sitosterolemia structural biology ABCG5 and ABCG8 genes are situated head-to-head on opposite strands...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 399–410.
Published: 07 February 2019
... the Creative Commons Attribution License 4.0 (CC BY) . Cryo-EM Mediator complex structural biology transcription The Mediator complex was initially identified in yeast in the early 1990s independently by the Kornberg and the Young laboratories. The Kornberg laboratory isolated Mediator...
Includes: Supplementary data
Articles
Cryo-EM in drug discovery
Open AccessIn Collection
Awards
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 281–293.
Published: 15 January 2019
...Tom Ceska; Chun-Wa Chung; Rob Cooke; Chris Phillips; Pamela A. Williams The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including...
Articles
Structural mass spectrometry comes of age: new insight into protein structure, function and interactions
Available to PurchaseIn Collection
Protein structure and function
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
.... mass spectrometry membrane proteins proteomics structural biology Mass spectrometry (MS) has evolved in recent years to become a pillar for integrative structural biology approaches. Structural MS provides a plethora of information, from protein primary structure and post-translational...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1753–1770.
Published: 13 December 2018
...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases structural biology...
Articles
Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1475–1484.
Published: 04 December 2018
... structural biology ABC transporters are characterised by a common domain structure consisting of two transmembrane domains (TMDs), each consisting of multiple transmembrane α-helices, followed by two nucleotide-binding domains (NBDs) that extend into the cytosol ( Figure 1 ). The TMDs and NBDs...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1495–1504.
Published: 21 November 2018
... © 2018 The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . membrane proteins protein purification structural biology structural...
Articles
Membrane protein engineering to the rescue
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1541–1549.
Published: 31 October 2018
... structural biology transmembrane proteins Proteins tend to be classified into one of two broad categories, globular cytoplasmic proteins and integral membrane proteins (IMPs) [ 1 ]. This simple classification is defined by a proteins intrinsic ability to produce a stable, functional structure...
Articles
Protein structure and computational drug discovery
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1367–1379.
Published: 21 September 2018
... biochemistry drug discovery and design structural biology Computational methods of drug discovery have a basis in the very earliest structural studies of protein molecules. The first structure of a protein, that of sperm whale myoglobin initially at 6 Å resolution [ 1 ] then refined to 2 Å resolution...
Articles
Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 379–389.
Published: 14 March 2018
... lipid-binding domains lipids membranes microfilaments structural biology Lipid membranes determine the shape of the cell surface and organelles. The lipid membrane is a bilayer consisting of phospholipids, sphingolipids, and cholesterol in various proportion [ 1 ]. Phospholipids...
Articles
Overcoming bottlenecks in the membrane protein structural biology pipeline
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 838–844.
Published: 09 June 2016
... the native lipid bilayer of a membrane protein during purification and biophysical analysis. Overcoming bottlenecks in the membrane protein structural biology pipeline, primarily by maintaining protein stability, will facilitate the elucidation of many more membrane protein structures in the near future...
Articles
Carbohydrate-active enzymes: sequences, shapes, contortions and cells
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 79–87.
Published: 09 February 2016
... Press Limited 2016 biofuels conformational analysis drug design glycobiology glycosidase structural biology Glycans are found almost everywhere, and the enzymes that synthesize, modify and degrade these complex molecules are central to human health and disease and our modern...
Articles
Recent structural and mechanistic insights into protein O -GalNAc glycosylation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 61–67.
Published: 09 February 2016
... by Portland Press Limited 2016 GalNAc-Ts retention mechanism structural biology lectin domain flexible linker enzyme dynamics Glycosyltransferases (GTs) are an ubiquitous group of enzymes that catalyse the transfer of sugar moieties from activated donors, mostly nucleotide sugars...
Articles
Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 52–58.
Published: 23 January 2014
... to phospholipase D [ 13 ] and phospholipase Cδ1 [ 14 ], suggesting a role in lipid metabolism and membrane trafficking. GTPase NMR Ral Ral-binding protein 1 (RalBP1) Ral-interacting protein of 76 kDa (RLIP76) structural biology Although we know the structures of the recognizable domains in RLIP76...
Articles
Microbial hydrogen splitting in the presence of oxygen
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1317–1324.
Published: 23 September 2013
... structural biology Hydrogen is one of the energy carriers of the future. The investigation of hydrogen metabolism from bacteria and archaea has a strong impact on possible scenarios for future energy supply [ 1 ]. Hydrogenases are enzymes which catalyse the reversible oxidation of molecular hydrogen...
Articles
The structural mechanisms that underpin mitotic kinase activation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 1037–1041.
Published: 18 July 2013
... should be addressed (email [email protected] ). 26 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 activation mechanism Aurora-A drug discovery Nek7 protein kinase structural biology On the basis of measurements of kinase activity and analysis...
Articles
Techniques to examine nucleotide binding by pseudokinases
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 975–980.
Published: 18 July 2013
... correspondence should be addressed (email [email protected] ). 3 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 catalytic activity fluorescence-based assay kinase-affinity chromatography nucleotide binding pseudokinase structural biology...
Articles
Type IV secretion machinery: molecular architecture and function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 17–28.
Published: 29 January 2013
... describes the best-characterized Type IVA secretion system where most of the structural biology efforts have been centred for many years revealing architectural details for various components of the T4S system. The nomenclature of genes in the archetypal A. tumefaciens VirB/D4 T4S system is the easiest...
Articles
The 2011 Joint Sino–U.K. Protein Symposium
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1311–1312.
Published: 21 September 2011
... of structural biology of proteins, presentations covering both historical and current research were given by a number of leading biochemists from both countries. Papers based on these talks have been prepared for this issue of Biochemical Society Transactions . 1 Correspondence may be addressed to either...
Articles
The stressosome: molecular architecture of a signalling hub
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 928–933.
Published: 26 July 2010
... Journal compilation © 2010 Biochemical Society 2010 Bacillus subtilis kinase signal transduction stressosome stress response structural biology The established model of Gram-positive micro-organisms is the soil-dwelling rod-shaped Bacillus subtilis . This organism has long been...
Articles
Crystallography and protein–protein interactions: biological interfaces and crystal contacts
Available to PurchaseBostjan Kobe, Gregor Guncar, Rebecca Buchholz, Thomas Huber, Bohumil Maco, Nathan Cowieson, Jennifer L. Martin, Mary Marfori, Jade K. Forwood
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... Society 2008 acyl-CoA thioesterase 7 (Acot7) platelet glycoprotein Ibα protein–protein interaction structural biology thrombin X-ray crystallography The growth in combining other techniques with the traditional approaches of MX, NMR and EM (electron microscopy) shows both the benefits...
Articles
The emerging role of MS in structure elucidation of protein–nucleic acid complexes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 723–731.
Published: 22 July 2008
... topological arrangements of subunits and interactions within RNA–protein complexes studied in our laboratory over the last 5 years. These studies exemplify the emerging role and potential of MS as a complementary structural biology methodology and demonstrate its unique niche in investigations of dynamic...
Articles
The structural biology of voltage-gated calcium channel function and regulation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 887–893.
Published: 25 October 2006
...-dependent inactivation (CDI) calmodulin (CaM) IQ domain structural biology voltage-gated calcium channel (Ca V ) Voltage-gated calcium channels (Ca V s) play a unique role in the interplay between electrical and chemical signalling in biological systems [ 1 , 2 ]. Ca V s respond to membrane...