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Keyword: sumoylation
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Articles
Biochem Soc Trans (2019) BST20190534.
Published: 26 November 2019
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . DNA synthesis and repair double strand break DUB SENP sumoylation ubiquitin DNA double stranded breaks are highly toxic lesions that occur when both strands of DNA are broken. The breaks can be formed from...
Articles
Biochem Soc Trans (2017) 45 (5): 1137-1148.
Published: 22 September 2017
... Biochemical Society 2017 deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate to...
Articles
Biochem Soc Trans (2010) 38 (1): 54-59.
Published: 19 January 2010
... of these authors (email atalamillo@cicbiogune.es or rbarrio@cicbiogune.es ). 2 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 adrenal cortex small ubiquitin-related modifier (SUMO) steroidogenesis steroid receptor SUMOylation ubiquitylation...
Articles
Biochem Soc Trans (2009) 37 (5): 937-953.
Published: 21 September 2009
... © The Authors Journal compilation © 2009 Biochemical Society 2009 deubiquitinase linear ubiquitin lysine linkage NEDDylation phosphorylation SUMOylation ubiquitination There is hardly any protein in the cell that does not encounter a post-translational modification within its...
Articles
Biochem Soc Trans (2008) 36 (5): 868-873.
Published: 19 September 2008
...Ana Talamillo; Jonatan Sánchez; Rosa Barrio SUMOylation, a reversible process used as a ‘fine-tuning’ mechanism to regulate the role of multiple proteins, is conserved throughout evolution. This post-translational modification affects several cellular processes by the modulation of subcellular...
Articles
Biochem Soc Trans (2008) 36 (3): 445-448.
Published: 21 May 2008
... deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function. 1 To whom correspondence should be addressed (email cormac.taylor...
Articles
Biochem Soc Trans (2007) 35 (6): 1379-1384.
Published: 23 November 2007
...F.Z. Watts; A. Skilton; J.C.-Y. Ho; L.K. Boyd; M.A.M. Trickey; L. Gardner; F.-X. Ogi; E.A. Outwin SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that...
Articles
Biochem Soc Trans (2007) 35 (6): 1433-1435.
Published: 23 November 2007
...Y.-C. Wu; A.F. Deyrieux; V.G. Wilson SUMOylation of viral proteins is widespread and serves to modify or regulate the properties of those proteins. Papillomaviruses are a large group of small DNA viruses that infect the skin, leading to benign lesions (warts) that in some cases can progress to...
Articles
Biochem Soc Trans (2007) 35 (6): 1414-1418.
Published: 23 November 2007
...B. Guo; S.-H. Yang; J. Witty; A.D. Sharrocks The modification of proteins by SUMO (small ubiquitin-related modifier) conjugation is becoming increasingly recognized as an important regulatory event. Protein SUMOylation can control a whole range of activities, including subcellular localization...
Articles
Biochem Soc Trans (2007) 35 (6): 1419-1421.
Published: 23 November 2007
... enzyme 9)], and substrate modification, through the co-operation of Ubc9 and E3 protein ligases. Work from our laboratory has shown the first example of a viral protein, Gam1, that binds to the E1 heterodimer, inhibiting its function and causing a complete block of the SUMOylation pathway both in vivo...
Articles
Biochem Soc Trans (2007) 35 (6): 1422-1423.
Published: 23 November 2007
... conjugated to monomeric SUMO, all three SUMO family members are able to multimerize in vitro . In cells, SUMOs have the potential to multimerize via internal consensus sites for SUMOylation that are present in SUMO-2 and SUMO-3. A SUMO-binding motif in Ubc9 (ubiquitin-conjugating enzyme 9) contributes to...
Articles
Biochem Soc Trans (2007) 35 (6): 1397-1400.
Published: 23 November 2007
... and co-activators have been identified, little is known about the mechanism underlying SUMOylation-elicited transcriptional repression. Here, we summarize that SUMO modification of transcription factors such as androgen receptor, glucocorticoid receptor, Smad4 and CBP [CREB (cAMP-response-element...
Articles
Biochem Soc Trans (2007) 35 (6): 1401-1404.
Published: 23 November 2007
... 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chromobox 4 (Cbx4) E3 ligase polycomb 2 protein (Pc2) polycomb repressive complex (PRC) small ubiquitin-related modifier (SUMO)-binding motif (SBM) SUMOylation The human and mouse genomes each encode at...