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Keywords: supercoiling
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Articles
Biochem Soc Trans (2024) 52 (6): 2321–2331.
Published: 07 November 2024
... supercoiling topoisomerases In prokaryotic cells, DNA is compacted in the cytoplasm to form the nucleoid, a dynamic structure that undergoes various topological changes during the cell cycle. To maintain DNA homeostasis, bacteria use specialized enzymes called topoisomerases. These enzymes...
Articles
Biochem Soc Trans (2013) 41 (2): 565–570.
Published: 21 March 2013
... simulations. 1 To whom correspondence should be addressed (email [email protected] ). 2 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 atomistic simulation DNA circle minicircle supercoiling topoisomerase Although the role of DNA...
Articles
Biochem Soc Trans (2013) 41 (2): 554–558.
Published: 21 March 2013
...David Swigon; Sookkyung Lim; Yongsam Kim In the present article, we summarize our recent studies of DNA dynamics using the generalized immersed boundary method. Our analysis of the effects of electrostatic repulsion on the dynamics of DNA supercoiling revealed that, after perturbation, a pre...
Articles
Biochem Soc Trans (2013) 41 (2): 491–493.
Published: 21 March 2013
... by the topology of the DNA strands or polypeptide chains respectively. During DNA replication, transcription or recombination, DNA molecules become supercoiled, knotted or catenated (linked). These processes are dynamic and are modulated by the activity of site-specific recombinases, which break double-stranded...
Articles
Biochem Soc Trans (2013) 41 (2): 646–651.
Published: 21 March 2013
...Jorge B. Schvartzman; María-Luisa Martínez-Robles; Pablo Hernández; Dora B. Krimer DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases. In the present article...
Articles
Biochem Soc Trans (2010) 38 (2): 438–442.
Published: 22 March 2010
...Andrew D. Bates; Anthony Maxwell Type II DNA topoisomerases catalyse changes in DNA topology in reactions coupled to the hydrolysis of ATP. In the case of DNA gyrase, which can introduce supercoils into DNA, the requirement for free energy is clear. However, the non-supercoiling type II enzymes...
Articles
Biochem Soc Trans (2005) 33 (6): 1460–1464.
Published: 26 October 2005
... couples the free energy of ATP hydrolysis to the introduction of negative supercoiling, and the structural details of this process are now becoming clearer. The homologous type IIA enzymes such as topo IV and eukaryotic topo II also require ATP and it has more recently been shown that the energy...