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Keywords: synaptic plasticity
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Articles
Biochem Soc Trans (2018) 46 (6): 1697–1705.
Published: 04 December 2018
... kinase stress synapses synaptic plasticity Waves of protein-based signaling networks become activated and inactivated during development in a tightly orchestrated and genetically controlled process that produces appropriately wired neural circuits [ 1 ]. As young vertebrates interact...
Articles
Biochem Soc Trans (2016) 44 (5): 1313–1319.
Published: 19 October 2016
... phosphatase PP2B synaptic plasticity The present study focuses on how protein–protein interactions between protein phosphatase-2B (PP2B), also known as calcineurin, and substrates and anchoring proteins influence physiological processes controlled by this enzyme. Reversible protein...
Articles
Biochem Soc Trans (2015) 43 (3): 328–332.
Published: 01 June 2015
... translation, is required for synaptic plasticity, i.e., for learning and long-term memory [ 15 , 16 ] and that eEF2K is expressed in neurons. Figure 2 Signalling pathways that regulate eEF2K activity ( A ) Neural signals lead to elevated Ca 2+ -ion levels and the transient activation of eEF2K...
Articles
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... in the hippocampus from degradation and furthermore protected synaptic plasticity. Importantly, the Aβ plaque load and the total amount of Aβ in the brain was much reduced. Also, the chronic inflammatory response that is found in AD was also much reduced [ 47 ]. This result found in transgenic mice that started...
Articles
Biochem Soc Trans (2013) 41 (4): 815–820.
Published: 18 July 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) microRNA biogenesis nervous system neuropathogenesis synaptic plasticity Non-coding RNAs are vital functional and regulatory elements of all biological systems. A class of small phylogenetically conserved 21–22...
Articles
Biochem Soc Trans (2013) 41 (1): 241–244.
Published: 29 January 2013
... and RNAs contained in exosomes secreted by emitting neurons could directly modify signal transduction and protein expression in receiving cells. Exosomes may be an ideal mechanism for anterograde and retrograde information transfer across synapses underlying local changes in synaptic plasticity. Exosomes...
Articles
Biochem Soc Trans (2010) 38 (6): 1527–1530.
Published: 24 November 2010
... is modified by the frequency with which the synapses are stimulated. This modulation of synaptic strength, or synaptic plasticity, probably forms the cellular basis for learning and memory. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting...
Articles
Biochem Soc Trans (2010) 38 (2): 493–497.
Published: 22 March 2010
..., molecular and behavioural analyses of experimental animal models of PD. In PD, a host of cellular and synaptic changes occur in the striatum in response to the massive loss of DA innervation. Chronic L -dopa therapy restores physiological synaptic plasticity and behaviour in treated PD animals, but most...
Articles
Biochem Soc Trans (2009) 37 (6): 1369–1374.
Published: 19 November 2009
... in neuronal differentiation, neuronal migration, synaptogenesis, structural remodelling, long-lasting forms of synaptic plasticity and higher cognitive functions. NMDAR-mediated Ca 2+ signalling in dendritic spines is not static, but can be remodelled in a cell- and synapse-specific manner by NMDAR subunit...
Articles
Biochem Soc Trans (2009) 37 (6): 1323–1327.
Published: 19 November 2009
...- D -aspartate (NMDA) spatial learning synaptic plasticity Glutamate is the major excitatory neurotransmitter in the central nervous system, exerting its actions via both ionotropic and metabotropic receptors. There are multiple subtypes of glutamate receptors, and some of these subtypes...
Articles
Biochem Soc Trans (2009) 37 (6): 1375–1377.
Published: 19 November 2009
...Donna M. McDade; Ann-Marie Conway; Allan B. James; Brian J. Morris The regulation of synaptic glutamate receptor and GABA A R (γ-aminobutyric acid subtype A receptor) levels is a key component of synaptic plasticity. Most forms of neuronal plasticity are associated with the induction...
Articles
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
...), and evidence is accumulating that leptin modulates many neuronal functions. In particular, recent studies have indicated that leptin plays an important role in the regulation of hippocampal synaptic plasticity. Indeed leptin-insensitive rodents display impairments in hippocampal synaptic plasticity and defects...
Articles
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
... the role of localized translational control in synaptic plasticity. It remains to be seen if the high-throughput methods can be applied quantitatively to study the dynamics of RNP (ribonucleoprotein) remodelling in specific neuronal populations during the neurodegenerative process. It is certain, however...
Articles
Biochem Soc Trans (2009) 37 (6): 1359–1363.
Published: 19 November 2009
...Mascia Amici; Andrew Doherty; Jihoon Jo; David Jane; Kwangwook Cho; Graham Collingridge; Sheila Dargan Calcium entry plays a major role in the induction of several forms of synaptic plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can...
Articles
Biochem Soc Trans (2006) 34 (5): 939–941.
Published: 25 October 2006
... 2006 active zone Bruchpilot calcium channel neuromuscular junction synaptic plasticity vesicle fusion Several fundamental questions remain open. Is the heterogeneous speed of vesicle fusion upon Ca 2+ influx a general phenomenon or only found at specialized synapses? Are different...
Articles
Biochem Soc Trans (2006) 34 (5): 949–951.
Published: 25 October 2006
...J.R. Mellor Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA ( N -methyl- D -aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4...
Articles
Biochem Soc Trans (2006) 34 (4): 600–604.
Published: 21 July 2006
... B) to glutamate synapses makes this system attractive as a dynamic, activity-dependent regulator of excitatory transmission and synaptic plasticity in the adult brain. Development of stable LTP (long-term potentiation) in response to high-frequency stimulation requires new gene expression...
Articles
Biochem Soc Trans (2006) 34 (1): 59–63.
Published: 20 January 2006
... phosphoproteome protein function proteome synapse synaptic plasticity synaptosome In this era of fully sequenced genomes, the daily life of molecular biologists has been transformed by the simple expediency of looking up the sequence of the gene of interest and knowing its structure and similarity...
Articles
Biochem Soc Trans (2005) 33 (6): 1354–1356.
Published: 26 October 2005
... © 2005 The Biochemical Society 2005 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) calcium/calmodulin-dependent protein kinase (CaMKII) long-term potentiation (LTP) phosphorylation protein kinase A (PKA) synaptic plasticity AMPA α-amino-3-hydroxy...
Articles
Biochem Soc Trans (2005) 33 (6): 1345–1349.
Published: 26 October 2005
... and serine). Mouse KOs (knockouts) revealed that, in different types of synapses, RIM1α is essential for different forms of synaptic plasticity. In CA1-region Schaffer-collateral excitatory synapses and in GABAergic synapses (where GABA is γ-aminobutyric acid), RIM1α is required for maintaining normal...
Articles
Biochem Soc Trans (2005) 33 (5): 1029–1032.
Published: 26 October 2005
... display abnormal brain development and leptin actively participates in the development of the hypothalamus. In the hippocampus, leptin is a potential cognitive enhancer as genetically obese rodents with dysfunctional leptin receptors display impairments in hippocampal synaptic plasticity. Moreover, direct...