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Keyword: synaptic plasticity
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Articles
Biochem Soc Trans (2018) 46 (6): 1697–1705.
Published: 04 December 2018
... leucine-rich repeat kinase stress synapses synaptic plasticity Waves of protein-based signaling networks become activated and inactivated during development in a tightly orchestrated and genetically controlled process that produces appropriately wired neural circuits [ 1 ]. As young vertebrates...
Articles
Biochem Soc Trans (2016) 44 (5): 1313–1319.
Published: 19 October 2016
...@uw.edu ) 2 6 2016 9 7 2016 14 7 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 AKAP79 anchoring protein calcineurin phosphatase PP2B synaptic plasticity The present study focuses on how protein–protein...
Articles
Biochem Soc Trans (2015) 43 (3): 328–332.
Published: 01 June 2015
..., PO Box 11060, Adelaide, SA 5001, Australia. 2 email Christopher.proud@sahmri.com 22 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 eEF2 mRNA translation nutrient protein synthesis synaptic plasticity tumour Eukaryotic elongation...
Articles
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... neurodegeneration oxidative stress synaptic plasticity The majority of AD (Alzheimer's disease) and PD (Parkinson's disease) cases are ‘sporadic’, which means that there is no clear genetic pathway that causes the onset of the disease. This makes it more difficult to identify which factors trigger the...
Articles
Biochem Soc Trans (2013) 41 (4): 815–820.
Published: 18 July 2013
... Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) microRNA biogenesis nervous system neuropathogenesis synaptic plasticity Non-coding RNAs are vital functional and regulatory elements of all biological systems. A class of small phylogenetically conserved 21–22...
Articles
Biochem Soc Trans (2013) 41 (1): 241–244.
Published: 29 January 2013
... and RNAs contained in exosomes secreted by emitting neurons could directly modify signal transduction and protein expression in receiving cells. Exosomes may be an ideal mechanism for anterograde and retrograde information transfer across synapses underlying local changes in synaptic plasticity...
Articles
Biochem Soc Trans (2010) 38 (6): 1527–1530.
Published: 24 November 2010
... is modified by the frequency with which the synapses are stimulated. This modulation of synaptic strength, or synaptic plasticity, probably forms the cellular basis for learning and memory. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long...
Articles
Biochem Soc Trans (2010) 38 (2): 493–497.
Published: 22 March 2010
..., molecular and behavioural analyses of experimental animal models of PD. In PD, a host of cellular and synaptic changes occur in the striatum in response to the massive loss of DA innervation. Chronic L -dopa therapy restores physiological synaptic plasticity and behaviour in treated PD animals, but most of...
Articles
Biochem Soc Trans (2009) 37 (6): 1369–1374.
Published: 19 November 2009
... neuronal differentiation, neuronal migration, synaptogenesis, structural remodelling, long-lasting forms of synaptic plasticity and higher cognitive functions. NMDAR-mediated Ca 2+ signalling in dendritic spines is not static, but can be remodelled in a cell- and synapse-specific manner by NMDAR subunit...
Articles
Biochem Soc Trans (2009) 37 (6): 1375–1377.
Published: 19 November 2009
...Donna M. McDade; Ann-Marie Conway; Allan B. James; Brian J. Morris The regulation of synaptic glutamate receptor and GABA A R (γ-aminobutyric acid subtype A receptor) levels is a key component of synaptic plasticity. Most forms of neuronal plasticity are associated with the induction of the...
Articles
Biochem Soc Trans (2009) 37 (6): 1323–1327.
Published: 19 November 2009
...) hippocampus lesion N -methyl- D -aspartate (NMDA) spatial learning synaptic plasticity Glutamate is the major excitatory neurotransmitter in the central nervous system, exerting its actions via both ionotropic and metabotropic receptors. There are multiple subtypes of glutamate receptors, and...
Articles
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
... role of localized translational control in synaptic plasticity. It remains to be seen if the high-throughput methods can be applied quantitatively to study the dynamics of RNP (ribonucleoprotein) remodelling in specific neuronal populations during the neurodegenerative process. It is certain, however...
Articles
Biochem Soc Trans (2009) 37 (6): 1359–1363.
Published: 19 November 2009
...Mascia Amici; Andrew Doherty; Jihoon Jo; David Jane; Kwangwook Cho; Graham Collingridge; Sheila Dargan Calcium entry plays a major role in the induction of several forms of synaptic plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can...
Articles
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
... evidence is accumulating that leptin modulates many neuronal functions. In particular, recent studies have indicated that leptin plays an important role in the regulation of hippocampal synaptic plasticity. Indeed leptin-insensitive rodents display impairments in hippocampal synaptic plasticity and defects...
Articles
Biochem Soc Trans (2006) 34 (5): 939–941.
Published: 25 October 2006
... 2006 active zone Bruchpilot calcium channel neuromuscular junction synaptic plasticity vesicle fusion Synapses are specialized intercellular contact sites, required for the rapid transmission of signals between neurons and their target cells. Chemical synaptic communication is mediated...
Articles
Biochem Soc Trans (2006) 34 (5): 949–951.
Published: 25 October 2006
...J.R. Mellor Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA ( N -methyl- D -aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4...
Articles
Biochem Soc Trans (2006) 34 (4): 600–604.
Published: 21 July 2006
... B) to glutamate synapses makes this system attractive as a dynamic, activity-dependent regulator of excitatory transmission and synaptic plasticity in the adult brain. Development of stable LTP (long-term potentiation) in response to high-frequency stimulation requires new gene expression and...
Articles
Biochem Soc Trans (2006) 34 (1): 59–63.
Published: 20 January 2006
... function proteome synapse synaptic plasticity synaptosome In this era of fully sequenced genomes, the daily life of molecular biologists has been transformed by the simple expediency of looking up the sequence of the gene of interest and knowing its structure and similarity to all other genes...
Articles
Biochem Soc Trans (2005) 33 (6): 1345–1349.
Published: 26 October 2005
... serine). Mouse KOs (knockouts) revealed that, in different types of synapses, RIM1α is essential for different forms of synaptic plasticity. In CA1-region Schaffer-collateral excitatory synapses and in GABAergic synapses (where GABA is γ-aminobutyric acid), RIM1α is required for maintaining normal...
Articles
Biochem Soc Trans (2005) 33 (6): 1354–1356.
Published: 26 October 2005
... 2005 © 2005 The Biochemical Society 2005 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) calcium/calmodulin-dependent protein kinase (CaMKII) long-term potentiation (LTP) phosphorylation protein kinase A (PKA) synaptic plasticity A major component...
Articles
Biochem Soc Trans (2005) 33 (5): 1029–1032.
Published: 26 October 2005
... display abnormal brain development and leptin actively participates in the development of the hypothalamus. In the hippocampus, leptin is a potential cognitive enhancer as genetically obese rodents with dysfunctional leptin receptors display impairments in hippocampal synaptic plasticity. Moreover, direct...