...David G. Nicholls Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire...

... of their sites and can exchange strands directionally, despite the fact that there is no net release of chemical bond energy. The key to this regulation is that they are only active within a large intertwined complex called the ‘synaptosome’. Because substrate topology greatly facilitates (or, in other cases...

... Society 2010 calcium sensor intracellular calcium nerve terminal neurotransmitter release signalling synaptosome It is well established in presynaptic nerve terminals that depolarization-dependent Ca 2+ ec (extracellular Ca 2+ ) influx through VDCCs (voltage-dependent Ca 2+ channels...

.... Meskenaite V. Brunner E. Ruthishauser D. Walther P. Eng J. Aebersold R. Sonderegger P. Proteomic analysis of synaptosomes using isotope-coded affinity tags and mass spectrometry Proteomics 2005 5 2631 2641 22 Waseem T.V. Kolos V.A. Lapatsina L.P...

... © 2006 The Biochemical Society 2006 phosphoproteome protein function proteome synapse synaptic plasticity synaptosome In this era of fully sequenced genomes, the daily life of molecular biologists has been transformed by the simple expediency of looking up the sequence of the gene...