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Biochem Soc Trans (2018) 46 (4): 937–944.
Published: 31 July 2018
... 2018 25 6 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 co-translational folding silent SNP translation translation kinetics tRNA On the ribosome, proteins are synthesized from N- to C-terminus, and regulation...
Biochem Soc Trans (2017) 45 (2): 339–351.
Published: 13 April 2017
... code is degenerate, with 61 nucleotide triplet codons encoding 20 different amino acids [ 78 ]. As a result, all amino acids, except methionine and tryptophan, are encoded by two or more ‘synonymous’ codons. Adding to this complexity, most tRNA anticodon triplets can recognize more than one synonymous...
Biochem Soc Trans (2016) 44 (5): 1367–1375.
Published: 19 October 2016
... for protein synthesis during cell growth and division. Here, we review the regulatory mechanisms that control the levels of RNAPIII transcripts and discuss their potential physiological relevance. Recent analyses have revealed differential regulation of tRNA expression at all steps on its biogenesis...
Biochem Soc Trans (2016) 44 (4): 1073–1078.
Published: 15 August 2016
... non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in human disease, mutations associated with the more classically defined ncRNAs have also been increasingly recognized as causing disease. These classical ncRNAs are the tRNAs, small nuclear RNAs (snRNAs), telomerase RNA, small nucleolar RNAs (snoRNAs...
Biochem Soc Trans (2014) 42 (1): 160–165.
Published: 23 January 2014
... by controlling ribosome flux across the mRNA. Variations in the abundance of tRNA molecules cause different rates of translation of their counterpart codons. This, in turn, produces a variable landscape of translational rate across each and every mRNA, with the dynamic formation and deformation of ribosomal...
Biochem Soc Trans (2013) 41 (1): 411–415.
Published: 29 January 2013
... palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and tRNA in Nanoarchaeum equitans . The minimal and fragmented genome of this tiny archaeon permits a sequencing depth that enables the identification of processing intermediates in the study of RNA processing pathways. These intermediates include...
Biochem Soc Trans (2002) 30 (6): 1131–1137.
Published: 01 November 2002
... substrates, we showed that the 2'-OH group of the terminal adenosine is important for peptidyl transfer. These substrates were also used to investigate the metal ion dependency of the peptidyl transferase reaction. Key words: ribosomal complex, ribozyme, RNA metal-ion-binding site, tRNA. Abbreviations used...
Biochem Soc Trans (2002) 30 (6): 1159–1161.
Published: 01 November 2002
... Molecular movement is inherent in the mech- anism of translation. Each tRNA must move by distances of 20-70A during each step of the translocational elongation cycle [l]. There is in- creasing evidence that movement of tRNA is coupled to corresponding movements within the ribosome structure itself...