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Keywords: tRNA
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Articles
Biochem Soc Trans (2024) BST20230770.
Published: 26 April 2024
...-transcribed genes include tRNA genes, adenovirus VA RNA genes, SINE elements and others. The ICRs harbor an A-box and B-box which are recognized by TFIIIC, followed by TFIIIB recruitment [ 15 , 16 ]. Class III is composed of the U6 snRNA gene (except yeast), 7SL/7SK RNA genes and others. Transcription...
Articles
Biochem Soc Trans (2018) 46 (4): 937–944.
Published: 31 July 2018
... of the Biochemical Society 2018 co-translational folding silent SNP translation translation kinetics tRNA Major developments in high-throughput technologies for global analysis of translation, such as ribosome profiling [ 7 ], have greatly advanced our understanding of the impact...
Articles
Biochem Soc Trans (2017) 45 (2): 339–351.
Published: 13 April 2017
..., except methionine and tryptophan, are encoded by two or more ‘synonymous’ codons. Adding to this complexity, most tRNA anticodon triplets can recognize more than one synonymous codon. This occurs through non-Watson-Crick ‘wobble’ base pairing at the third position of the codon (the first anticodon...
Articles
Biochem Soc Trans (2016) 44 (5): 1367–1375.
Published: 19 October 2016
... for protein synthesis during cell growth and division. Here, we review the regulatory mechanisms that control the levels of RNAPIII transcripts and discuss their potential physiological relevance. Recent analyses have revealed differential regulation of tRNA expression at all steps on its biogenesis...
Articles
Biochem Soc Trans (2016) 44 (4): 1073–1078.
Published: 15 August 2016
... (TERC) tRNA Eukaryotic genomes are pervasively transcribed producing a plethora of RNA species. These RNAs are essential for many of the important functions in the cell, from the making of proteins to the copying of DNA during cell replication. It is, therefore, not surprising that mutations...
Articles
Biochem Soc Trans (2014) 42 (1): 160–165.
Published: 23 January 2014
... by controlling ribosome flux across the mRNA. Variations in the abundance of tRNA molecules cause different rates of translation of their counterpart codons. This, in turn, produces a variable landscape of translational rate across each and every mRNA, with the dynamic formation and deformation of ribosomal...
Articles
Biochem Soc Trans (2013) 41 (1): 411–415.
Published: 29 January 2013
... palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and tRNA in Nanoarchaeum equitans . The minimal and fragmented genome of this tiny archaeon permits a sequencing depth that enables the identification of processing intermediates in the study of RNA processing pathways. These intermediates include...
Articles
Biochem Soc Trans (2002) 30 (6): 1131–1137.
Published: 01 November 2002
... substrates, we showed that the 2'-OH group of the terminal adenosine is important for peptidyl transfer. These substrates were also used to investigate the metal ion dependency of the peptidyl transferase reaction. Key words: ribosomal complex, ribozyme, RNA metal-ion-binding site, tRNA. Abbreviations used...
Articles
Biochem Soc Trans (2002) 30 (6): 1159–1161.
Published: 01 November 2002
... Molecular movement is inherent in the mech- anism of translation. Each tRNA must move by distances of 20-70A during each step of the translocational elongation cycle [l]. There is in- creasing evidence that movement of tRNA is coupled to corresponding movements within the ribosome structure itself...