... by the participation of University of Liverpool in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. enzymology epidermal growth factor receptor mechanotransduction molecular scaffolds signalling talin...

... [email protected] ). 29 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 CD9 focal adhesion integrin migration talin tetraspanin 4th European Conference on Tetraspanins: An Independent Meeting held at the University of Birmingham, Birmingham, U.K...

... is the binding of talin to integrin β cytoplasmic domains. We used forward, reverse and synthetic genetics to engineer and order integrin activation pathways of a prototypic integrin, platelet αIIbβ3. PMA activated αIIbβ3 only after expression of both PKCα (protein kinase Cα) and talin at levels approximating...

...Iain D. Campbell Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction...

... that interact directly with the β-chain cytoplasmic domain, talin has emerged as playing a critical role in integrin activation and linkage to the actin cytoskeleton. Talin (2541 amino acids) is an elongated (60 nm) flexible antiparallel dimer, with a small globular head connected to an extended rod. The talin...

... The Biochemical Society 2006 folded protein guanine nucleotide dissociation inhibitor (GDI) Rho GTPase protein–protein interaction talin vinculin Figure 1 Structure of talin-(1843–1973), showing the four-helix bundle (colouring from blue at the N-terminus to red at the C-terminus) The helix...

...D.R. Critchley The cytoskeletal protein talin plays a key role in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton. In this paper I present a brief review on talin and summarize our recent studies, in which we have taken both genetic and structural approaches...

...D.R. Critchley The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly...

... their action on integrin cytoplasmic domains, induce conformational changes in integrin extracellular domains, resulting in increased affinity for the ligand. Recent results indicate that the binding of talin, a major actin-binding protein, to integrin β tails represents a final common step in integrin...