... © The Authors Journal compilation © 2013 Biochemical Society 2013 difference topology DNA knot Mu transpososome recombinase tangle topoisomerase The shape of DNA has many fascinating biological consequences. For example, high levels of compaction can lead to DNA knotting (e.g. [ 1...

... in this field has traditionally focused on understanding how hyperphosphorylated and aggregated tau mediates dysfunction and toxicity in tauopathies. Recent findings from both Drosophila and rodent models of tauopathy suggest that large insoluble aggregates such as tau filaments and tangles may not be the key...