Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Subjects
Article Type
Date
Availability
1-29 of 29
Keywords: tau
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 301–318.
Published: 13 February 2024
...Mohammed M. Alhadidy; Nicholas M. Kanaan Tau protein is associated with many neurodegenerative disorders known as tauopathies. Aggregates of tau are thought of as a main contributor to neurodegeneration in these diseases. Increasingly, evidence points to earlier, soluble conformations of abnormally...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (3): 827–838.
Published: 13 May 2019
..., and tau have been associated with familial and sporadic forms of the disease. aSyn is the major component of Lewy bodies and Lewy neurites, which are pathognomonic protein inclusions in PD. Hyperphosphorylated tau protein accumulates in neurofibrillary tangles in the brains of Alzheimer's disease patients...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1058–1062.
Published: 19 September 2012
... orchestrated by LRRK2 and deregulated under pathological conditions. 1 email [email protected] 7 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophosphorylation GTPase leucine-rich repeat kinase 2 (LRRK2) moesin Parkinson's disease tau...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1080–1085.
Published: 19 September 2012
... (LRRK2) Parkinson's disease tau Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene at the PARK8 locus cause incompletely penetrant autosomal dominant PD (Parkinson's disease), which is considered clinically and neuropathologically indistinguishable from sporadic PD. LRRK2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 693–697.
Published: 20 July 2012
...Catherine M. Cowan; Shmma Quraishe; Amritpal Mudher Insoluble aggregates of the microtubule-associated protein tau characterize a number of neurodegenerative diseases collectively termed tauopathies. These aggregates comprise abnormally hyperphosphorylated and misfolded tau proteins. Research...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 641–643.
Published: 20 July 2012
...Efthimios M.C. Skoulakis; Amritpal Mudher It is an exciting time for tau researchers as it is now generally accepted that abnormal tau species are required to mediate the toxic effects of amyloid β-peptide oligomers in Alzheimer's disease. Tau may play multiple roles in neurophysiology...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 687–692.
Published: 20 July 2012
...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 721–727.
Published: 20 July 2012
... and fibrils of the Aβ (amyloid β-peptide) and tau protein accumulate in specific brain regions. This is associated with the progressive destruction of synaptic circuits controlling memory and higher mental function. The primary signalling mechanisms that (i) become defective in AD to alter the normal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 667–671.
Published: 20 July 2012
...Sarah M. Ward; Diana S. Himmelstein; Jody K. Lancia; Lester I. Binder AD (Alzheimer's disease) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β-peptide and the intracellular accumulation of tau. Although there is much evidence linking tau...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 644–652.
Published: 20 July 2012
...Yipeng Wang; Eckhard Mandelkow Tau aggregates are present in several neurodegenerative diseases and correlate with the severity of memory deficit in AD (Alzheimer's disease). However, the triggers of tau aggregation and tau-induced neurodegeneration are still elusive. The impairment of protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 677–680.
Published: 20 July 2012
...Michael Niblock; Jean-Marc Gallo Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain. Several MAPT mutations causing the familial tauopathy, FTDP-17 (frontotemporal dementia...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 672–676.
Published: 20 July 2012
...Anne Rovelet-Lecrux; Dominique Campion Mutations of the MAPT (microtubule-associated protein tau) gene are associated with FTLD (frontotemporal lobar degeneration) with tau pathology. These mutations result in a decreased ability of tau to bind MTs (microtubules), an increased production of tau...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer Tauopathies are neurodegenerative diseases, including AD (Alzheimer's disease) and FTLD-T (tau-positive frontotemporal lobar degeneration), with shared pathology presenting as accumulation of detergent-insoluble hyperphosphorylated tau deposits...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1012–1015.
Published: 26 July 2010
...Amy M. Pooler; Diane P. Hanger Tau is an abundant microtubule-associated protein which regulates the stability of the cytoskeleton. Tau binds microtubules directly through microtubule-binding domains in its C-terminus. However, tau is not only located in the cytosol of cells, but also associated...
Articles
Kunie Ando, Karelle Leroy, Céline Heraud, Anna Kabova, Zehra Yilmaz, Michèle Authelet, Valèrie Suain, Robert De Decker, Jean-Pierre Brion
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1001–1005.
Published: 26 July 2010
...Kunie Ando; Karelle Leroy; Céline Heraud; Anna Kabova; Zehra Yilmaz; Michèle Authelet; Valèrie Suain; Robert De Decker; Jean-Pierre Brion We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 981–987.
Published: 26 July 2010
...Katerina Papanikolopoulou; Stylianos Kosmidis; Sofia Grammenoudi; Efthimios M.C. Skoulakis The heterogeneous pathology of tauopathies and the differential susceptibility of different neuronal types to WT (wild-type) and mutant tau suggest that phosphorylation at particular sites rather than...
Articles
NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease
Isabelle Landrieu, Arnaud Leroy, Caroline Smet-Nocca, Isabelle Huvent, Laziza Amniai, Malika Hamdane, Nathalie Sibille, Luc Buée, Jean-Michel Wieruszeski, Guy Lippens
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1006–1011.
Published: 26 July 2010
...Isabelle Landrieu; Arnaud Leroy; Caroline Smet-Nocca; Isabelle Huvent; Laziza Amniai; Malika Hamdane; Nathalie Sibille; Luc Buée; Jean-Michel Wieruszeski; Guy Lippens NMR spectroscopy was used to explore the different aspects of the normal and pathological functions of tau, but proved challenging...
Articles
Luc Buée, Laëtitia Troquier, Sylvie Burnouf, Karim Belarbi, Anneke Van der Jeugd, Tariq Ahmed, Francisco Fernandez-Gomez, Raphaelle Caillierez, Marie-Eve Grosjean, Séverine Begard, Bérangère Barbot, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Valérie Buée-Scherrer, Claude-Alain Maurage, Detlef Balschun, Rudi D'Hooge, Malika Hamdane, David Blum, Nicolas Sergeant
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 967–972.
Published: 26 July 2010
... Balschun; Rudi D'Hooge; Malika Hamdane; David Blum; Nicolas Sergeant Tau pathology is characterized by intracellular aggregates of abnormally and hyperphosphorylated tau proteins. It is encountered in many neurodegenerative disorders, but also in aging. These neurodegenerative disorders are referred...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 993–995.
Published: 26 July 2010
...Frank M. LaFerla Aβ (amyloid β-peptide) and tau are the main proteins that misfold and accumulate in amyloid plaques and NFTs (neurofibrillary tangles) of Alzheimer's disease and other neurological disorders. Historically, because plaques and NFTs accumulate in diverse cellular compartments, i.e...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1016–1020.
Published: 26 July 2010
...Diane P. Hanger; Selina Wray Deposition of highly phosphorylated tau in the brain is the most significant neuropathological and biochemical characteristic of the group of neurodegenerative disorders termed the tauopathies. The discovery of tau fragments in these diseases suggests that tau cleavage...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1021–1025.
Published: 26 July 2010
... on ApoE transcription, protein synthesis and secretion. In CSF (cerebrospinal fluid) collected form from patients with cognitive impairment (Alzheimer's disease and patients with mild cognitive impairment) the levels of ApoE, tau, p-tau (hyperphosphorylated tau) were significantly increased, together...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 953–954.
Published: 26 July 2010
...Efthimios M.C. Skoulakis; Amritpal Mudher Tauopathies are a clinically diverse group of neurodegenerative dementias involving perturbations of the level or phosphorylation state of the microtubule-binding axonal protein tau. Despite intense effort in recent years, the precise role of tau...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 973–976.
Published: 26 July 2010
...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer We previously developed a transgenic Caenorhabditis elegans model of human tauopathy disorders by expressing human tau in nematode worm neurons to explore genetic pathways contributing to tau-induced neurodegeneration. This animal model...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 996–1000.
Published: 26 July 2010
...] are still imperfectly understood. Many transgenic mice overexpressing wild-type or mutant tau proteins have been generated to investigate the physiopathology of tauopathies. Most of the mice overexpressing wild-type tau do not develop NFTs, but can develop a severe axonopathy, whereas overexpression...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 977–980.
Published: 26 July 2010
...Jesús Avila; Elena Gómez de Barreda; Tobias Engel; Jose J. Lucas; Félix Hernández The MAP (microtubule-associated protein) tau binds to tubulin, the main component of MTs (microtubules), which results in the stabilization of MT polymers. Tau binds to the C-terminal of tubulin, like other MAPs...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 955–961.
Published: 26 July 2010
...Yipeng Wang; Sarika Garg; Eva-Maria Mandelkow; Eckhard Mandelkow Tau aggregation is a hallmark of several neurodegenerative diseases, including AD (Alzheimer's disease), although the mechanism underlying tau aggregation remains unclear. Recent studies show that the proteolysis of tau plays...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 545–551.
Published: 22 March 2010
...Ayodeji A. Asuni; V. Hugh Perry; Vincent O'Connor Hyperphosphorylation of the microtubule-associated protein tau is a significant determinant in AD (Alzheimer's disease), where it is associated with disrupted axonal transport and probably causes synaptic dysfunction. Although less well studied...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 591–594.
Published: 01 August 2005
... the molecular mechanisms leading to dementia. The chief neuropathological changes during Alzheimer's disease, namely neurofibrillary tangles and amyloid plaques, have helped us to determine which molecules to focus upon in the animal models, specifically Aβ (amyloid β) and tau. This paper presents my...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 578–581.
Published: 01 August 2005
...J. Hardy Loci underlying autosomal dominant forms of most neurodegenerative disease have been identified: prion mutations cause Gerstmann Straussler syndrome and hereditary Creutzfeldt–Jakob disease, tau mutations cause autosomal dominant frontal temporal dementia and α-synuclein mutations cause...
