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Keywords: tau knockout
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Articles
Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model
Available to PurchaseKunie Ando, Karelle Leroy, Céline Heraud, Anna Kabova, Zehra Yilmaz, Michèle Authelet, Valèrie Suain, Robert De Decker, Jean-Pierre Brion
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1001–1005.
Published: 26 July 2010
... of human tauopathy. By crossing the Tg30tau line with TauKO (tau-knockout) mice, we have obtained a new mouse line called Tg30×TauKO that expresses only exogenous human double-mutant 4R1N tau. Whereas Tg30×TauKO mice express fewer tau proteins compared with Tg30tau, they exhibit augmented sarkosyl...
