... correspondence should be addressed (email [email protected] ) . 28 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Alzheimer’s disease astrocyte glia inflammation tauopathy Alzheimer's disease (AD) is a progressive neurodegenerative disease...

...Catherine M. Cowan; Shmma Quraishe; Amritpal Mudher Insoluble aggregates of the microtubule-associated protein tau characterize a number of neurodegenerative diseases collectively termed tauopathies. These aggregates comprise abnormally hyperphosphorylated and misfolded tau proteins. Research...

... and there may be further pathologically relevant tau alterations, besides hyperphosphorylation and aggregation. The recent Biology and Pathology of Tau and its Role in Tauopathies II meeting explored these various aspects of tau, and presentations at the meeting, described in the following articles...

...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...

...Kurt R. Brunden; Carlo Ballatore; Virginia M.-Y. Lee; Amos B. Smith, III; John Q. Trojanowski Neurons within the brains of those with AD (Alzheimer's disease) and related neurodegenerative disorders, collectively termed ‘tauopathies’, contain fibrillar inclusions composed of hyperphosphorylated tau...

...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer Tauopathies are neurodegenerative diseases, including AD (Alzheimer's disease) and FTLD-T (tau-positive frontotemporal lobar degeneration), with shared pathology presenting as accumulation of detergent-insoluble hyperphosphorylated tau deposits...

...Khalid Iqbal; Xiaochuan Wang; Julie Blanchard; Fei Liu; Cheng-Xin Gong; Inge Grundke-Iqbal Independent of the aetiology, AD (Alzheimer's disease) neurofibrillary degeneration of abnormally hyperphosphorylated tau, a hallmark of AD and related tauopathies, is apparently required for the clinical...

... the utility of Drosophila models for enhancing our understanding of the pathological mechanisms that underpin human neurodegenerative diseases. The Biology of Tau and its Role in Tauopathies: A Biochemical Society Focused Meeting held at Robinson College, Cambridge, U.K., 7–8 January 2010. Organized...

...Diane P. Hanger; Selina Wray Deposition of highly phosphorylated tau in the brain is the most significant neuropathological and biochemical characteristic of the group of neurodegenerative disorders termed the tauopathies. The discovery of tau fragments in these diseases suggests that tau cleavage...

...Efthimios M.C. Skoulakis; Amritpal Mudher Tauopathies are a clinically diverse group of neurodegenerative dementias involving perturbations of the level or phosphorylation state of the microtubule-binding axonal protein tau. Despite intense effort in recent years, the precise role of tau...

...Jean-Pierre Brion; Kunie Ando; Céline Heraud; Karelle Leroy NFTs (neurofibrillary tangles) in Alzheimer's disease and in tauopathies are hallmark neuropathological lesions whose relationship with neuronal dysfunction, neuronal death and with other lesions [such as Aβ (amyloid β-peptide) pathology...

... through unknown mechanisms, independently of tau aggregation. Blocking the truncation of tau thus may represent a promising therapeutic approach for AD or other tauopathies. In the present paper, we summarize our data on tau cleavage in a cell model of tauopathy and major results on tau cleavage reported...

...F. Chee; A. Mudher; T.A. Newman; M. Cuttle; S. Lovestone; D. Shepherd Synaptic dysfunction is believed to be an early pathological change in neurodegenerative diseases and may cause the earliest clinical symptoms. We have used Drosophila to model a tauopathy in order to analyse the earliest...

... in explaining the phenotypic variability that is so typical of neurodegeneration in general. In this review, we will explore the clinicopathological diversity of the tau-related disorders with specific reference to three of the most common tauopathies, frontotemporal dementia (familial and sporadic...