..., neurodegenerative diseases such as Alzheimer's and prion diseases, bacterial infection and inflammatory diseases such as heart attack, stroke and asthma. However, targetting ADAM10 is likely to result in toxic side effects. The tetraspanins are a superfamily of 33 four-transmembrane proteins in mammals which...

...Rebecca L. Bailey; John M. Herbert; Kabir Khan; Victoria L. Heath; Roy Bicknell; Michael G. Tomlinson Tetraspanins function as organizers of the cell surface by recruiting specific partner proteins into tetraspanin-enriched microdomains, which regulate processes such as cell adhesion, signalling...

...Hong-Xing Wang; Qinglin Li; Chandan Sharma; Konstantin Knoblich; Martin E. Hemler Among the 33 human tetraspanin proteins, CD151, CD9 and Tspan12 play particularly important roles in cancer. Tetraspanin CD151, in partnership with integrins α6β1 and α6β4, modulates tumour cell growth, invasion...

... rejection have been attributed to aberrant fusion. Members of the tetraspanin protein superfamily have been ascribed multiple roles in membrane biology, forming extensive lateral associations and regulating the function of effector molecules by clustering them in specific areas of the membrane. The present...

...Markus Thali By virtue of their multiple interactions with partner proteins and due to their strong propensity to multimerize, tetraspanins create scaffolds in membranes, recruiting or excluding specific proteins needed for particular cellular processes. We and others have shown that (i) HIV-1...

...Michelle J. Farquhar; Helen J. Harris; Jane A. McKeating CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry...

... promising therapeutic tool for multiple diseases. However, whereas knowledge on the composition of exosomes is rapidly increasing, the mode of selective recruitment into exosomes as well as target cell selection is poorly understood. We suggest that at least part of this task is taken over by tetraspanins...

...Eric Rubinstein Tetraspanins compose a family of structurally related molecules with four transmembrane domains. A total of 33 tetraspanins are present in the human genome, and tetraspanins are also found in plants and certain fungi. A well-known property of tetraspanins is their ability...

...Jean-François Haeuw; Liliane Goetsch; Christian Bailly; Nathalie Corvaia CD151 is a plasma membrane protein belonging to the tetraspanin superfamily which is expressed on normal cells such as endothelial cells and platelets and frequently overexpressed on cancer cells. It is known...

...Eleanor Livingston Jones; Maria C. Demaria; Mark D. Wright Tetraspanins are a superfamily of integral membrane proteins involved in the organization of microdomains that consist of both cell membrane proteins and cytoplasmic signalling molecules. These microdomains are important in regulating...

...Nicklas Bonander; Mohammed Jamshad; Ke Hu; Michelle J. Farquhar; Zania Stamataki; Peter Balfe; Jane A. McKeating; Roslyn M. Bill Tetraspanins are thought to exert their biological function(s) by co-ordinating the lateral movement and trafficking of associated molecules into tetraspanin-enriched...

...Annemiek B. van Spriel The tetraspanins represent a large superfamily of four-transmembrane proteins that are expressed on all nucleated cells. Tetraspanins play a prominent role in the organization of the plasma membrane by co-ordinating the spatial localization of transmembrane proteins...

...Dale Powner; Petra M. Kopp; Susan J. Monkley; David R. Critchley; Fedor Berditchevski Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked...

...María Yáñez-Mó; Francisco Sánchez-Madrid; Carlos Cabañas TEMs (tetraspanin-enriched microdomains) are specialized platforms in the plasma membrane that include adhesion receptors and enzymes. Insertion into TEMs dictates the local concentration of these molecules, regulates their internalization...

... rupture of atherosclerotic plaques. Current anti-platelet therapy is not effective in all patients and carries a risk of bleeding. As such, a major goal in platelet research is to identify new drug targets to specifically inhibit platelets in disease processes. Tetraspanins are potential candidates...

... responses and can be regulated through the formation of multimolecular complexes. Tetraspanins as facilitators and building blocks of specialized microdomains may be involved in this process. In the present study, we demonstrated that, in contrast with previous reports, integrin-mediated adhesion did...

.... Marsh M. In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53 J. Cell Biol. 2007 177 329 341 13 Welsch S. Keppler O.T. Habermann A. Allespach I. Krijnse-Locker J. Krausslich H.G. HIV-1 buds...

... Society 2007 plasminogen plasminogen activator tetraspanin transmembrane serine protease type II transmembrane serine protease (TTSP) urokinase plasminogen activator receptor (uPAR) Surprisingly, CD82 and uPAR did not co-localize on the cell surface, although uPAR was found...

..., prion protein tPA, tissue plasminogen activator uPA, urokinase-type plasminogen activator uPAR, uPA receptor VSMC, vascular smooth muscle cell plasminogen plasminogen activator prion tetraspanin urokinase-type plasminogen activator receptor Non-Haemostatic Role for Blood Coagulation...