... on the significant immunoregulatory role of SEMA4D and the associated underlying mechanisms, as well as the potential application of SEMA4D as a diagnostic marker and therapeutic target for the treatment of immunological diseases. Correspondence: Dongzhe Song ( [email protected] ) or Dingming Huang...

... propose that copper-binding and/or -chaperoning proteins, especially MTs, are potential therapeutic targets for HD. Pairwise comparisons were conducted using a two-tailed Student's t test and 95% (*) or 99% (**) confidence intervals were used for calculating significance. The number of experiments...

... is implicating serine proteases within apoptotic processing, particularly in the generation of nuclear events such as condensation, fragmentation and DNA degradation observed in late-stage apoptosis. Serine proteases therefore are emerging as providing additional or alternative therapeutic targets...

... been shown to act as negative regulators of the apoptotic cascade [ 3 ]. Thus hsps have a dual functionality and can act both as modulators of survival and death-signalling pathways and as protein chaperones. They are therefore an attractive choice for therapeutic targeting in neurodegenerative...