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Keyword: therapeutics
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Biochem Soc Trans (2019) 47 (5): 1209-1222.
Published: 10 September 2019
... and it has been demonstrated that disruption of some of these proteins can cause cancer-specific inhibition of cell growth. For certain targets therapeutically relevant interventions are being investigated, for example, small molecule inhibitors, although none are yet in clinical trials. As the field...
Biochem Soc Trans (2018) 46 (4): 891-909.
Published: 19 July 2018
...Ruby Macdonald; Katy Barnes; Christopher Hastings; Heather Mortiboys Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for...
Biochem Soc Trans (2017) 45 (1): 101-112.
Published: 15 February 2017
... Biochemical Society 2017 neurodegeneration protein phosphatases therapeutics translation factors unfolded protein response With the greater access to healthcare, many countries have seen sharp increases in the lifespan of their populations. This in turn has contributed to a rising global...
Biochem Soc Trans (2017) 45 (1): 79-88.
Published: 15 February 2017
...Galina Semenova; Jonathan Chernoff p21-Activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small...
Biochem Soc Trans (2016) 44 (5): 1483-1490.
Published: 19 October 2016
...Carlo Viscomi Mitochondrial disorders are a group of genetic diseases affecting the energy-converting process of oxidative phosphorylation. The extreme variability of symptoms, organ involvement, and clinical course represent a challenge to the development of effective therapeutic interventions...
Biochem Soc Trans (2015) 43 (4): 593-594.
Published: 03 August 2015
... pharmacology therapeutics TSPO In search of the mechanisms underlying human and animal physiopathology, it is a necessity to comprehend how body, tissues and cells adapt to continuous stimuli coming from the environment [ 1 ]. Whether these are physical, psychosocial or chemical adaptation to these...
Biochem Soc Trans (2010) 38 (2): 507-510.
Published: 22 March 2010
... s.till@ed.ac.uk 24 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 cognitive impairment development Fragile X mental retardation protein (FMRP) Fragile X syndrome (FXS) therapeutics The Fragile X clinical phenotype is associated with deficits in...
Biochem Soc Trans (2007) 35 (4): 767-769.
Published: 20 July 2007
... for biomedical research and, as witnessed in 2007, candidate and emerging therapeutics. Thus it is anticipated that the further refinement of CPP technologies will provide drug-delivery vectors, cellular imaging tools, nanoparticulate devices and molecular therapeutics that will have a positive impact...
Biochem Soc Trans (2007) 35 (1): 1-6.
Published: 22 January 2007
... © 2007 The Biochemical Society 2007 diagnostics epidermal growth factor receptor (EGFR) growth factor signalling therapeutics This short review describes the work that I have been doing for the last 45 years on growth factors, their receptors and signal transduction mechanisms. When I...
Biochem Soc Trans (2005) 33 (1): 306-310.
Published: 01 February 2005
... ‘GK-switch’. The case of GK research illustrates how basic science may culminate in therapeutic advances of human medicine. 1 To whom correspondence should be addressed (email matsch@mail.med.upenn.edu ). 2 9 2004 © 2005 The Biochemical Society 2005 drug discovery genetics...