... drug discovery [ 3 ]. Owing to the inherent instability of GPCRs when removed from membranes, considerable attention is paid to finding conditions to maximize stability and minimize unfolding. Thermostability can be used to assess whether the solubilizing conditions are optimal. This can...

... than stabilizing purposes. 1 To whom correspondence should be addressed (e-mail [email protected] ). Thermophiles 2003, a held at University of Exeter, 15–19 September 2003 19 September 2003 © 2004 Biochemical Society 2004 hyperthermophile thermostability...

... channelling molecular physiology thermostability Abbreviations used: CP, carbamoyl phosphate; CPSase, carbamoyl phosphate synthetase; CKase, carbamate kinase; OTCase, ornithine carbamoyltransferase; ATCase, aspartate carbamoyltransferase. 306 Biochemical Society Transactions (2004) Volume 32...

... fusion thermostability Abbreviation used: 4HB, four-helix bundle. Thermophiles 2003 227 Archaeal histones: structures, stability and DNA binding J.N. Reeve1, K.A. Bailey, W-t. Li, F. Marc, K. Sandman and D.J. Soares Department of Microbiology, Ohio State University, Columbus, OH 43210...

... dismutases from archaeal prokaryotes. The mechanism and the extreme thermostability of superoxide dismutase from Sulfolobus acidocaldarius are discussed on the basis of its high-resolution X-ray structure. An alternating-site mechanism and an evolutionary origin of superoxide dismutases under...