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Keywords: thioesterase
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Biochem Soc Trans (2020) 48 (1): 281–290.
Published: 24 December 2019
... plasticity, endocytosis, vesicle trafficking, membrane transport and biased-receptor signalling. As a consequence, zDHHC-protein acyl transferases (zDHHC-PATs), enzymes that catalyse the addition of fatty acid groups to specific cysteine residues on target proteins, and acyl proteins thioesterases, proteins...
Biochem Soc Trans (2017) 45 (4): 913–921.
Published: 16 June 2017
... 4 2017 7 4 2014 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 ABHD17A ABHD17B ABHD17C APT1 palmostatin B thioesterase The Ras family of proteins consists of small GTPases (guanosine triphosphatases) that play a role...
Biochem Soc Trans (2016) 44 (3): 774–782.
Published: 09 June 2016
... the lipid bilayer to release CoA, and ultimately re-esterified in the peroxisome lumen by ACSs which interact with the transporter. We propose that this solves the biophysical problem of moving an amphipathic molecule across the peroxisomal membrane, since the intrinsic thioesterase activity...
Biochem Soc Trans (2015) 43 (5): 959–965.
Published: 09 October 2015
... thioesterase activity of the transporter releases fatty acids which may be flip-flopped in the membrane and released into the peroxisome, where they are re-esterified by the activity of LACS6 and 7. A pool of LACS6/7 protein is physically associated with CTS on the lumenal side of the membrane [ 45 ] and ATP...
Biochem Soc Trans (2015) 43 (2): 193–198.
Published: 07 April 2015
... thioesterases (APTs). Although initially identified as lysophospholipases, increasing evidence suggests APT1 and APT2 are the major APTs that mediate the depalmitoylation of diverse cellular substrates. Here, we describe the conserved functions of APT1 and APT2 across organisms and discuss the possibility...
Biochem Soc Trans (2013) 41 (1): 43–49.
Published: 29 January 2013
... are the enzymes that catalyse palmitoylation and depalmitoylation? mass spectrometry (MS) palmitoylation post-translational modification proteomics thioesterase Protein palmitoylation was first discovered over 30 years ago in classic experiments using tritiated palmitate for metabolic...