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Keywords: thymocyte
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 651–656.
Published: 22 May 2014
... cells into mature CD4 + or CD8 + T-lymphocytes. We have characterized the requirements for differentiation within these cultures and used this system to compare the ability of CD34 + cells derived from different sources to produce mature thymocytes. The TREC (T-cell receptor excision circle) assay...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 177–180.
Published: 20 March 2007
... thymocyte The class IB catalytic isoform p110γ is well established as a regulator of chemotaxis in neutrophils [ 2 ]. In T-cells, p110γ appears to be a more minor player in chemokine-driven homing and motility, for which another signalling pathway regulated by DOCK2 (dedicator of cytokinesis 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 167–171.
Published: 20 March 2007
..., we review the role of PI3Ks in T-cell development and function. colitis forkhead box O (Foxo) p110δ phosphoinositide 3-kinase (PI3K) T-cell thymocyte The PI3K p110δ plays a key role in the context of antigen receptor signalling. The dual impact of p110δ on Th and Treg development...