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Keywords: thymocyte
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Biochem Soc Trans (2014) 42 (3): 651–656.
Published: 22 May 2014
... cells into mature CD4 + or CD8 + T-lymphocytes. We have characterized the requirements for differentiation within these cultures and used this system to compare the ability of CD34 + cells derived from different sources to produce mature thymocytes. The TREC (T-cell receptor excision circle) assay...
Biochem Soc Trans (2007) 35 (2): 177–180.
Published: 20 March 2007
... (PI3K) regulatory T-cell (Treg) T-cell thymocyte Table 1 Phenotypes of mice lacking individual class I PI3K isoforms pAkt, phosphorylated Akt. Targeted gene Class Type Thymocyte development T-cell signalling and function P110δ [ 8 , 9 , 18 ] IA Catalytic Normal...
Biochem Soc Trans (2007) 35 (2): 167–171.
Published: 20 March 2007
... thymocyte T-cells are generated in the thymus from bone-marrow-derived precursor cells. Progenitor T-cells (thymocytes) are subject to three key selection events referred to as β-selection, positive selection and negative selection. During β-selection, immature CD4 − CD8 − DN (double negative...