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Keywords: topoisomerase
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Articles
Biochem Soc Trans (2013) 41 (2): 565–570.
Published: 21 March 2013
... simulations. 1 To whom correspondence should be addressed (email tony.maxwell@jic.ac.uk ). 2 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 atomistic simulation DNA circle minicircle supercoiling topoisomerase Although the role of DNA...
Articles
Biochem Soc Trans (2013) 41 (2): 571–575.
Published: 21 March 2013
...Ksenia Terekhova; John F. Marko; Alfonso Mondragón Topoisomerases are the enzymes responsible for maintaining the supercoiled state of DNA in the cell and also for many other DNA-topology-associated reactions. Type IA enzymes alter DNA topology by breaking one DNA strand and passing another strand...
Articles
Biochem Soc Trans (2013) 41 (2): 601–605.
Published: 21 March 2013
... © The Authors Journal compilation © 2013 Biochemical Society 2013 difference topology DNA knot Mu transpososome recombinase tangle topoisomerase The shape of DNA has many fascinating biological consequences. For example, high levels of compaction can lead to DNA knotting (e.g. [ 1...
Articles
Biochem Soc Trans (2013) 41 (2): 491–493.
Published: 21 March 2013
... ( andrzej.stasiak@unil.ch ). 24 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 catenane chromatin chromosome DNA knot protein folding recombinase supercoiling topoisomerase The structure and function of DNA and proteins are affected by the topology...
Articles
Biochem Soc Trans (2013) 41 (2): 646–651.
Published: 21 March 2013
...Jorge B. Schvartzman; María-Luisa Martínez-Robles; Pablo Hernández; Dora B. Krimer DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases. In the present article...
Articles
Biochem Soc Trans (2011) 39 (1): 58–63.
Published: 19 January 2011
... (email m.ciaramella@ibp.cnr.it ). 8 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 architectural protein chromosome structure DNA topology genome stability topoisomerase Maintaining the appropriate sign and density of DNA supercoiling is vital...
Articles
Biochem Soc Trans (2010) 38 (2): 381–383.
Published: 22 March 2010
... of remarkable enzymes has evolved, which includes translocases, polymerases/replicases, helicases, nucleases, topoisomerases, transposases, recombinases, repair enzymes and ribosomes. An understanding of how these enzymes function is essential if we are to have a clear view of the molecular biology of the cell...
Articles
Biochem Soc Trans (2010) 38 (2): 438–442.
Published: 22 March 2010
...Andrew D. Bates; Anthony Maxwell Type II DNA topoisomerases catalyse changes in DNA topology in reactions coupled to the hydrolysis of ATP. In the case of DNA gyrase, which can introduce supercoils into DNA, the requirement for free energy is clear. However, the non-supercoiling type II enzymes...
Articles
Biochem Soc Trans (2009) 37 (1): 69–73.
Published: 20 January 2009
...Giuseppe Perugino; Anna Valenti; Anna D'Amaro; Mosè Rossi; Maria Ciaramella Reverse gyrase is a DNA topoisomerase that is peculiar in many aspects: it has the unique ability to introduce positive supercoils into DNA molecules; it comprises a type IA topoisomerase fused to a helicase-like domain...
Articles
Biochem Soc Trans (2005) 33 (6): 1460–1464.
Published: 26 October 2005
...A. Maxwell; L. Costenaro; S. Mitelheiser; A.D. Bates Type IIA topos (topoisomerases) catalyse topological conversions of DNA through the passage of one double strand through a transient break in another. In the case of the archetypal enzyme, DNA gyrase, it has always been apparent that the enzyme...
Articles
Biochem Soc Trans (2005) 33 (6): 1465–1470.
Published: 26 October 2005
...A.J. Schoeffler; J.M. Berger DNA topos (topoisomerases) are complex, multisubunit enzymes that remodel DNA topology. Members of the type II topo family function by passing one segment of duplex DNA through a transient break in another, a process that consumes two molecules of ATP and requires...
Articles
Biochem Soc Trans (2004) 32 (6): 957–958.
Published: 26 October 2004
... cancer DNA repair helicase recombination topoisomerase The RecQ family of DNA helicases has received considerable interest due to their putative roles in suppression of cancer and premature ageing in humans [ 1 ]. Mutations in three different human RecQ helicase genes cause BS (Bloom's syndrome...
Articles
Biochem Soc Trans (2001) 29 (2): 201–204.
Published: 01 May 2001
.... 1 To whom correspondence should be addressed (e-mail hickson@icrf.icnet.uk ) 24 10 2000 © 2001 Biochemical Society 2001 cancer genetic recombination RecQ helicase topoisomerase BS, Bloom's syndrome RPA, replication protein A New Frontiers in DNA Repair 23 24 25 26...