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Keywords: trafficking
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2477–2486.
Published: 06 December 2024
... protein abundance at the plasma membrane (PM). Each of the mechanisms described in the text are illustrated in the context of a cell. The PM composition of a cell can be altered when: ( i ) lysosomal exocytosis delivers endolysosomal components to the PM; ( ii ) vesicular trafficking and sorting...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1473–1487.
Published: 12 June 2024
... Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement. cilia ciliopathy G-protein-coupled receptors intraflagellar transport trafficking TULP3 The primary cilium is a microtubule-based dynamic cellular appendage found in many...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 505–515.
Published: 17 April 2024
...Edward J. Chocano-Coralla; Luis Vidali In eukaryotic cells, organelle and vesicle transport, positioning, and interactions play crucial roles in cytoplasmic organization and function. These processes are governed by intracellular trafficking mechanisms. At the core of that trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 41–53.
Published: 22 February 2024
... in cardiomyocytes have begun to unveil essential functions for these enzymes in regulating cardiac development, homeostasis, and pathogenesis. Palmitoylation co-ordinates cardiac electrophysiology through direct modulation of ion channels and transporters to impact their trafficking or gating properties as well...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1621–1633.
Published: 03 August 2023
... and nucleus. GBP1, GBP2, and GBP5 can translocate to the Golgi after IFNγ stimulation and aluminium fluoride treatment (binds to produce a complex resembling the GTP hydrolysis transition state) [ 17 , 19 ]. This trafficking requires farnesylation, leading to membrane anchoring and the formation of larger...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 971–981.
Published: 19 June 2023
... is associated with the asthmatic disease state [ 75 ]. Cell-surface trafficking of LMAN1 is also involved in transporting pathogen proteins. Cholix, which is secreted by the intestinal pathogen Vibro cholera, undergoes transcytosis from apical vesicles to the basolateral region of cells by interacting...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1057–1069.
Published: 30 May 2023
... converges on multiple trafficking processes to deliver the glucose transporter GLUT4 to the cell surface. Impaired insulin-stimulated GLUT4 translocation in these tissues underlies insulin resistance, which is a major risk factor for type 2 diabetes and other metabolic diseases. Despite this, the precise...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 579–585.
Published: 09 March 2023
... trafficking for certain cell surface proteins and receptors. We recently found that disabling macropinocytosis by depletion of CYRI proteins led to enhanced surface integrin accumulation, enhancing invasiveness and adhesion of cancer cells [ 14 ]. Integrin is a known cargo of circular dorsal ruffles [ 27...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 331–342.
Published: 23 February 2023
... of new functions that include lipogenesis and Golgi vesicle trafficking. Here, we review recent insights into the role of CaMKK2 in membrane trafficking mechanisms and discuss the functional implications in a cellular context and for disease. Correspondence: Emma Evergren ( [email protected]...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 315–330.
Published: 11 January 2023
... scaling. The different AMPA receptor subunits (GluA1–GluA4) share a common modular structure and membrane topology, and their intracellular C-terminus tail is responsible for the interaction with intracellular proteins important in receptor trafficking. The latter sequence differs between subunits...
Articles
Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 507–517.
Published: 22 February 2021
...-endothelial trafficking of these substrates, may in fact be an early contributor towards the establishment of metabolic dysfunction and subsequent cardiovascular disease. Understanding the molecular mechanisms that underpin substrate trafficking through the endothelium represents an important area within...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 379–391.
Published: 22 February 2021
.../dephosphorylation protein–protein interactions trafficking Cellulose provides a potentially almost inexhaustible source of renewable carbon. Due to its high strength and stiffness, cellulose is a good candidate for producing biodegradable, non-toxic and high-strength materials at low cost [ 1 ]. Cellulose...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 467–476.
Published: 05 February 2021
... (Hh), the precise, cell cycle dependent orchestration of the MAPK-pathway appears to relay Ras activation in this context. We will examine how non-canonical activities of K-Ras4B (hereafter K-Ras) could be enabled by its trafficking chaperones calmodulin and PDE6D/PDEδ. Both dynamically localize...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...Agata Nawrotek; Mahel Zeghouf; Jacqueline Cherfils Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2261–2272.
Published: 14 October 2020
... trafficking Membrane trafficking is essential for human health and physiology. Trafficking pathways control and maintain the spatio-temporal organization of transmembrane proteins (sometimes called protein cargoes) within cells. Trafficking pathways enable diverse physiological processes, including...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
...-explored, how exactly does a single cell interpret a plethora of time-varying signals? Furthermore, how their subsequent responses at the single cell level manifest in the larger context of a developing tissue is unknown. At the same time, the biophysics and chemistry of how receptors are trafficked...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 83–93.
Published: 17 February 2020
... endowed with low and high affinity for ECM ligands. Increasing evidence proves that, differently to what hypothesized in the past, detachment from the ECM and conformational inactivation are not mandatory for integrin to get endocytosed and trafficked. Specific transmembrane and cytosolic proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 43–50.
Published: 22 December 2017
... trafficking [Int. J. Mol. Sci. (2013) 14 , 18670–18681; Traffic (2000) 1 , 836–851]. How then does the cell organize this enormous transfer of material in its crowded internal environment? And how specifically do vesicles carrying proteins and lipids recognize and fuse with the correct compartment...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... to be associated with canonical membrane trafficking, but several mechanistic details are still missing. In this review, the current understanding and potential mechanisms by which membrane trafficking participates in macroautophagy are described, with a focus on the enigma of the membrane protein Atg9, for which...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 771–779.
Published: 15 June 2017
... through its Bin–Amphiphysin–Rvs and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (2): 489–497.
Published: 13 April 2017
..., CD81, and CD63 and their interaction partners in host cell entry by human cytomegalo- and human papillomaviruses. Moreover, we discuss a model for tetraspanin assembly into trafficking platforms at the plasma membrane. These platforms might persist during intracellular viral trafficking. Figure 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1737–1744.
Published: 02 December 2016
... protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans , have revealed both that dimerization of this protein is essential for correct trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1273–1280.
Published: 19 October 2016
... with ADP ribosylation factor-like 13b (Arl13b) [ 13 – 15 ], suggesting the importance of GSF trafficking in healthy ciliogenesis. Figure 1. GSFs share structural fold with RhoGDI and bind to lipid-modified cargo and Arl2 via two different interfaces. ( A ) Superimposition of PDE6D (cyan), UNC119...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 891–897.
Published: 09 June 2016
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endosomal sorting lysosomes receptors trafficking vacuole The plant vacuole was first discovered in 1676 by a Dutch scientist Antonie van...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 185–190.
Published: 09 February 2016
...Heather Currinn; Thomas Wassmer Phosphoinositides are important components of eukaryotic membranes that are required for multiple forms of membrane dynamics. Phosphoinositides are involved in defining membrane identity, mediate cell signalling and control membrane trafficking events. Due...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 508–512.
Published: 01 June 2015
... regulating the trafficking of the cardiac sodium channel Na V 1.5 to the membrane. 1 To whom correspondence should be addressed (email [email protected] ) . 25 2 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 Cx43 intercalated disc microtubule Nav1.5...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
..., distribution and reproduction in any medium, provided the original work is properly cited. calcium fission fusion gliotransmission mitophagy trafficking Ca 2+ signalling is central for the regulation of astrocyte functions and for astrocyte–neuron communication. Mitochondria actively uptake...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
... by reintroduction of wild-type, but not kinase-dead, PI3K-C2α. These data indicate a selective role for PI3K-C2α in primary cilium elongation [ 12 ]. Further investigation revealed that PI3K-C2α specifically regulates the Sonic Hedgehog signalling pathway mainly by modulating trafficking of ciliary components [ 12...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
...Nicol Birsa; Rosalind Norkett; Nathalie Higgs; Guillermo Lopez-Domenech; Josef T. Kittler Correct mitochondrial dynamics are essential to neuronal function. These dynamics include mitochondrial trafficking and quality-control systems that maintain a precisely distributed and healthy mitochondrial...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (2): 681–686.
Published: 21 March 2013
... (glycogen synthase kinase 3), TSC2 and FOXO transcription factors. © The Authors Journal compilation © 2013 Biochemical Society 2013 cytotoxic T-lymphocyte glycolysis hypoxia-inducible factor 1α (HIF1α) mammalian target of rapamycin complex 1 (mTORC1) protein kinase B (PKB) trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 225–230.
Published: 29 January 2013
... platelets trafficking variants It is now well established that P2Y 12 receptor stimulation promotes platelet activation and thereby plays a central role in maintaining the physiological integrity of the vascular system while also playing a major role in the pathological development of thrombosis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 137–143.
Published: 29 January 2013
... trafficking With almost 1000 members, the heptahelical GPCRs (G-protein-coupled receptors) comprise the largest family of cell-surface receptors. They allow cells to detect and respond to extraordinarily diverse environmental and endogenous stimuli, and they participate in most aspects...
Articles
Sharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis, Ian A. Prior
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (6): 1409–1415.
Published: 21 November 2012
... of the Rab11 pathway in the trafficking, assembly and budding steps of these viruses. Figure 3 IAV budding in the presence or absence of normal levels of Rab11 ( A ) A549 cells were transfected with a non-targeting siRNA (control) or siRNA targeting Rab11a and Rab11b for 72 h and then infected with IAV...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
... have demonstrated the essential role of these proteins in lysosomal acidification, transport of metabolites resulting from hydrolytic degradation and interaction and fusion with other cellular membrane systems. In addition, trafficking pathways of lysosomal membrane proteins are closely linked...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1012–1015.
Published: 26 July 2010
..., membrane-associated tau is dephosphorylated at serine/threonine residues, suggesting that the phosphorylation state of tau regulates its intracellular trafficking. Dephosphorylation of tau may increase the association of tau with trafficking proteins which target tau to the plasma membrane. Thus...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 460–465.
Published: 22 March 2010
...Jonathan G. Hanley An important mechanism for the regulation of excitatory synaptic transmission in the hippocampus involves tight control of AMPAR [AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor] trafficking to alter the number or subtype of synaptic receptors...
Articles
Claudia S. Bauer, Wahida Rahman, Alexandra Tran-Van-Minh, Rafael Lujan, Anthony H. Dickenson, Annette C. Dolphin
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 525–528.
Published: 22 March 2010
... neuropathic pain pregabalin spinal nerve ligation trafficking voltage-gated calcium channel Unlike nociceptive or acute pain, neuropathic pain occurs without continuous noxious peripheral input. Patients with neuropathic pain experience spontaneous pain that is described as ‘electric-shock-like...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
...). In addition, leptin promotes rapid alterations in hippocampal dendritic morphology and synaptic density, which are likely to contribute to the effects of this hormone on excitatory synaptic strength. Recent studies have demonstrated that trafficking of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1060–1063.
Published: 25 October 2007
... but by inhibition of hERG/ I Kr trafficking to the cell surface. Important examples are antineoplastic Hsp90 (heat-shock protein 90) inhibitors such as (i) geldanamycin, (ii) the leukaemia drug arsenic trioxide, (iii) the antiprotozoical pentamidine, (iv) probucol, a cholesterol-lowering drug, and (v) fluoxetine...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1069–1073.
Published: 25 October 2007
...D.F. Steele; A. Dehghani Zadeh; M.E. Loewen; D. Fedida The proper trafficking and localization of cardiac potassium channels is profoundly important to the regulation of the regionally distinct action potentials across the myocardium. These processes are only beginning to be unravelled and involve...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
..., it has been shown that disease pathogenesis in LQT1 can be influenced by the abnormal trafficking of KCNQ1. In comparison, whether defective trafficking of KCNE1 plays a role in LQT5 is less well established. 5 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1077–1079.
Published: 25 October 2007
... drugs. 1 email [email protected] 24 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 action potential antiepileptic drug epilepsy mutation ion channel neuronal excitability trafficking Epilepsy is one of the most common...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
... trafficking in macrophages. 1 To whom correspondence should be addressed (email [email protected] ). 25 7 2006 © 2006 The Biochemical Society 2006 cholesterol liver X receptor (LXR) macrophage peroxisome-proliferator-activated receptor α (PPARα) trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 877–881.
Published: 25 October 2006
...F.A. Stephenson The fidelity of synaptic function is dependent on the expression of the appropriate neurotransmitter receptor subtype, the targeting and trafficking of receptors to synapses as well as the regulation of the actual number of receptors at synapses. GABA A (γ-aminobutyric acid type...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 48–50.
Published: 20 January 2006
...K. Pozo; F.A. Stephenson GRIF-1 [GABA A (γ-aminobutyric acid A ) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1040–1044.
Published: 26 October 2004
... of small G-proteins with GPCRs and GPCR-regulatory proteins may influence GPCR signalling and intracellular trafficking. 1 To whom correspondence should be addressed, at Cell Biology Research Group, Robarts Research Institute (email [email protected] ). 21 6 2004 © 2004...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 1–14.
Published: 01 February 2004
... and function, are trafficked to their required destination. Endocytosis plays, therefore, an important role in cell signalling, nutrient uptake, cellular homoeostasis and the interaction of the cell with its external environment. The formation of clathrin-coated endocytic vesicles requires the complex...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (4): 885–888.
Published: 01 August 2003
... with respect to its physiology and pharmacology, its cell-biological properties, such as subunit assembly, post-translational processing and trafficking in neurons, are only beginning to be addressed. Critical to many of the functions of the NMDA receptor are the multiple proteins with which it interacts...
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