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Keywords: transcription factors
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Articles
Biochem Soc Trans (2024) 52 (2): 821–830.
Published: 25 March 2024
... the parent cell's gene expression pattern, allowing for efficient transcriptional memory after division. Early studies in mammalian cells suggested that transcription factors (TFs) mark genes for swift reactivation, a phenomenon termed ‘mitotic bookmarking’, but conflicting data emerged regarding TF presence...
Articles
Biochem Soc Trans (2024) 52 (2): 617–626.
Published: 13 March 2024
... and less reactive, ceasing the production of newborn neurons. Although many genes involved in the regulation of NSCs have been identified using genetic manipulation and omics analyses, the entire regulatory network is complicated and ambiguous. In this review, we focus on transcription factors, whose...
Articles
Biochem Soc Trans (2023) 51 (6): 2163–2172.
Published: 28 November 2023
... cells. After entry into meiosis, several forms of regulatory events control the orderly progression of meiosis and the timely entry into post-meiotic sperm differentiation. Among other mechanisms, changes to gene expression are controlled by key transcription factors. In this review, we will discuss...
Articles
Biochem Soc Trans (2022) 50 (6): 1941–1952.
Published: 16 December 2022
...Sabab Hasan Khan; C. Denise Okafor The key players in transcriptional regulation are transcription factors (TFs), proteins that bind specific DNA sequences. Several mechanisms exist to turn TFs ‘on’ and ‘off’, including ligand binding which induces conformational changes within TFs, subsequently...
Articles
Biochem Soc Trans (2021) 49 (6): 2711–2726.
Published: 02 December 2021
...David M. Wood; Renwick C.J. Dobson; Christopher R. Horne Transcription is the principal control point for bacterial gene expression, and it enables a global cellular response to an intracellular or environmental trigger. Transcriptional regulation is orchestrated by transcription factors, which...
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Biochem Soc Trans (2020) 48 (5): 2205–2212.
Published: 20 October 2020
... a large pool of transcription factors and signaling proteins available, the pool of existing switches lacks the substrate specificities and activities required for certain applications. Therefore, a large number of techniques have been applied to engineer switches with novel properties. Here we discuss...
Articles
Biochem Soc Trans (2020) 48 (5): 2213–2227.
Published: 11 September 2020
... of transcription (STATs) are a family of transcription factors that are hyper-activated in most cancer types and while STATs are widely understood to be activated by the JAK family of kinases, many additional activators have been discovered. A growing number of examples of Rho-family driven STAT activation...
Articles
Biochem Soc Trans (2018) 46 (5): 1083–1091.
Published: 21 September 2018
... from proliferation to differentiation, revealing multiple bidirectional interactions between the cell cycle machinery and factors driving differentiation. Here, we focus on a direct mechanistic link involving phosphorylation of differentiation-associated transcription factors by cell cycle-associated...
Articles
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... by which homeostasis is maintained during health, in order to uncover strategies to boost homeostasis in disease. A case in point is redox homeostasis, maintained by antioxidant defences co-ordinately regulated by the transcription factor Nrf2, and capable of preventing not only oxidative stress but also...
Articles
Biochem Soc Trans (2016) 44 (5): 1367–1375.
Published: 19 October 2016
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . RNA polymerase III transcription elongation transcription factors tRNA The basic machinery for RNA transcription evolved prior to the last common ancestor of all extant organisms. Bacteria and Archaea retain a single...
Articles
Biochem Soc Trans (2002) 30 (2): 93–98.
Published: 01 April 2002
..., and expression can be increased by up to 100-fold by cytokines. There is a tissue-specific promoter for the liver, and alternative promoters for other tissues that express AAT. Basal AAT expression is regulated by the synergistic action of the tissue-specific transcription factors hepatocyte nuclear factors 1α...