... : several cancers, including lung, pancreatic, brain, liver and breast cancer; Arid2-IR : ureteral obstructive nephropathy; lincRNA-p21 : rheumatoid arthritis; PACER : several cancers including osteosarcoma. biomarkers disease gene expression inflammation lncRNA transcriptional regulation...

... expression and activity is essential. This regulation is exerted at multiple levels, including transcriptional regulation and proteasomal degradation. Recent studies revealed important roles of miRNAs (miRs) in the control of NRF2 activity through direct targeting of the NRF2 mRNA and of mRNAs encoding...

... global genome organization linked to transcriptional regulation Nucleic Acids Res. 2010 38 8164 8177 31 Osborne C.S. Chakalova L. Brown K.E. Carter D. Horton A. Debrand E. Goyenechea B. Mitchell J.A. Lopes S. Reik W. Active genes dynamically...

... or inactive [ 14 ], and gene expression from such promoters has to be activated from an upstream activation sequence such as the ara -box element. © The Authors Journal compilation © 2011 Biochemical Society 2011 activator archaeon transcriptional regulation transcription factor B-recognition...

... ]. Studies have shown that individual chromosomes have preferential neighbours in nuclei [ 3 ]; an organization which appears to be cell-type-specific [ 4 ]. gene positioning genome organization lamin protein nuclear matrix (NM) transcription factory transcriptional regulation Specific...

... [email protected] ). 11 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 genomics metal-regulatory transcription factor 1 (MTF1) small interfering RNA (siRNA) transcriptional regulation zinc MTF1 (metal-regulatory transcription factor 1...

... in transcriptional regulation. In the present paper, we shall review the literature demonstrating the action of p68 and, where data are available, p72 as transcriptional co-regulators for a range of transcription factors, namely ERα (oestrogen receptor α), the tumour suppressor p53, the myogenic regulator MyoD...

..., the challenge to understand how the individual genes are regulated within the cell remains. Here, I provide an overview of current computational methods to investigate transcriptional regulation. I will first discuss how representing protein–DNA interactions as a network provides us with a conceptual framework...

... and clinical settings. Transcriptional regulation, the ability to turn genes on and off, lies at the heart of these processes of lineage commitment and specification. We have focused on fully understanding how these decisions are made at a single mammalian gene locus, the α-globin genes, which become up...

... Biochemical Society 2008 chromatin switching ion channel oncogene transcriptional regulation tumour suppressor vascular disease Eukaryotic DNA is wrapped around histone proteins forming a complex known as chromatin. Although initially thought to solely serve a structural role, facilitating...

...-binding protein nucleotide analogue σ 54 transcriptional regulation bEBPs (bacterial enhancer-binding proteins) are AAA+ (ATPase associated with various cellular activities) family members involved in regulating bacterial gene expression. Regulated transcription in bacteria requires...

... The Authors Journal compilation © 2008 Biochemical Society 2008 ATPase associated with various cellular activites (AAA+) enhancer-binding protein σ 54 small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) transcriptional regulation Bacteria must adapt to environmental changes...

...F.V. Fuller-Pace; A.-M.F. Jacobs; S.M. Nicol SUMO (small ubiquitin-related modifier) modification is known to have diverse effects on the activity of transcriptional regulators, often through alterations in their localization or interactions with other factors, and in most of the cases...

...-shock protein 90 (Hsp90) heat-shock transcription factor (HSF) mitogen-activated protein kinase signalling (MAPK signalling) Slt2(Mpk1)p transcriptional regulation yeast cell integrity Our work has been supported by BBSRC (Biotechnology and Biological Sciences Research Council) grants 31...

... transcriptional regulation Altered macrophage functions contribute to the pathogenesis of many infectious, immunological and inflammatory disease processes. Pharmacological modulation of macrophage gene expression therefore represents an important strategy for the prevention and treatment of inflammation...

...S. Rinaldo; G. Giardina; M. Brunori; F. Cutruzzolà All denitrifiers can keep the steady-state concentrations of nitrite and nitric oxide (NO) below cytotoxic levels by controlling the expression of denitrification gene clusters by redox signalling through transcriptional regulators belonging...

... ). 21 6 2005 © 2005 The Biochemical Society 2005 chromatin immunoprecipitation–DNA microarray (ChIP-chip) gene circuit metabolism network component analysis (NCA) transcriptional regulation transcription factor Organisms respond to their environment through a series...

.... 1 To whom correspondence should be addressed (email [email protected] ). 20 6 2005 © 2005 The Biochemical Society 2005 DNA methylation epigenetic mechanism histone deacetylase methyl-CpG-binding domain protein transcriptional regulation tumorigenesis Another finding...

... for physiological studies. 1 To whom correspondence should be addressed (email [email protected] ). 25 9 2004 © 2005 The Biochemical Society 2005 anaerobiosis hybrid-cluster protein iron–sulphur–oxygen cluster nitrogen cycle transcription start mapping transcriptional regulation...

.../[ANS] tot will be linear for a fixed protein concentration with a common abscissa intercept of −1/ K , for different protein concentrations [ 12 ]. anaerobiosis denitrification nitric oxide Pseudomonas aeruginosa sensor transcriptional regulation In denitrifying bacteria...

... The Biochemical Society 2005 H 2 sensor HupUV HupT/HupR integration host factor (IHF) RegA Rhodobacter capsulatus transcriptional regulation In contrast, hydrogenase activity is practically nil in hupR mutants [ 6 , 7 ]. The difference with the wild-type is more striking when...

.... Kubilis J. Ferrante R.J. Ross B.D. Neve R. Ratan R.R. J. Neurosci. 2003 23 3597 3606 © 2004 The Biochemical Society 2004 Nramp1 oxidant stress specificity protein 1 (Sp1) transcriptional regulation Nramp1 (murine natural resistance-associated...

.... Lin X. Mol. Cell 2002 9 133 143 initiator element Miz-1 Nramp1 transcriptional regulation A single gene, termed Nramp1 / Slc11a1 (murine natural resistance-associated macrophage protein 1 gene/solute carrier family 11 member a1), confers resistance/susceptibility...