... in this model to accommodate the observations that wide-ranging translational stresses trigger its activation. collided ribosomes Gcn2 Gcn4 ribosome quality control the integrated stress response translational control Maintaining cellular homeostasis is a defining feature of life. To do so...

... their sensitivity, specificity, and resolution. In this review, we outline emerging Ribo-seq derivatives that overcome barriers in low inputs, rRNA contamination, data calibration, and single-cell applications. These advances enable detailed insights into translational control across diverse biological contexts...

...-apoptotic properties of eIF4E play an important role in attenuating chemo- and radiotherapy [ 41–43 ]. © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 cancer therapy eIF4F translational control Eukaryotic cytoplasmic translation...

... Attribution License 4.0 (CC BY-NC-ND) . ageing protein biosynthesis ribosome RNA translation translational control Cellular ageing refers to the progressive deterioration of cellular functions over time, often leading to cell cycle arrest (senescence) or cell death [ 1–3 ]. Ageing...

...Huili Guo The control of translation is increasingly recognized as a major factor in determining protein levels in the cell. The ribosome — the cellular machine that mediates protein synthesis — is typically seen as a key, but invariant, player in this process. This is because translational control...

... is modified by the frequency with which the synapses are stimulated. This modulation of synaptic strength, or synaptic plasticity, probably forms the cellular basis for learning and memory. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting...

... The Biochemical Society 2006 apoptosis eukaryotic initiation factor 2 (eIF2) protein kinase stress response translational control UV irradiation Phosphorylation of eIF2 reduces global protein synthesis concomitant with induced translation of selected mRNAs, such as those encoding the bZIP...

... that binding of the ligand tetracycline leads to a pseudoknot-like linkage within the aptamer structure, thereby inhibiting the initial steps of translation. A second translational control element was designed by combining a theophylline aptamer with a communication module for which a 1 nt slipping mechanism...

... factors. Arabidopsis homologues of ATB2 / AtbZIP11 , which harbour the conserved uORF, also show SIRT. Therefore, SIRT emerges as a general sucrose translational control mechanism of a group of transcription factors. SIRT might be part of a sucrose-specific signalling pathway, controlling expression...

... is only targeted to the mitochondria. This result raises intriguing questions on the translational control mechanisms that regulate how the protein products of a single transcript are targeted to more than one cellular compartment. 1 To whom correspondence should be addressed (email...