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Keywords: translational control
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Articles
Insights into the role of collided ribosomes during the activation of the integrated stress response
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (03): 615–626.
Published: 28 May 2025
... in this model to accommodate the observations that wide-ranging translational stresses trigger its activation. collided ribosomes Gcn2 Gcn4 ribosome quality control the integrated stress response translational control Maintaining cellular homeostasis is a defining feature of life. To do so...
Articles
Advances in ribosome profiling technologies
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (03): 555–564.
Published: 16 May 2025
... their sensitivity, specificity, and resolution. In this review, we outline emerging Ribo-seq derivatives that overcome barriers in low inputs, rRNA contamination, data calibration, and single-cell applications. These advances enable detailed insights into translational control across diverse biological contexts...
Articles
Therapeutic targeting of eukaryotic initiation factor (eIF) 4E
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 113–124.
Published: 20 January 2023
...-apoptotic properties of eIF4E play an important role in attenuating chemo- and radiotherapy [ 41–43 ]. © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 cancer therapy eIF4F translational control Eukaryotic cytoplasmic translation...
Articles
Translational control in cell ageing: an update
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2853–2869.
Published: 16 December 2021
... Attribution License 4.0 (CC BY-NC-ND) . ageing protein biosynthesis ribosome RNA translation translational control Cellular ageing refers to the progressive deterioration of cellular functions over time, often leading to cell cycle arrest (senescence) or cell death [ 1–3 ]. Ageing...
Articles
Specialized ribosomes and the control of translation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 855–869.
Published: 09 July 2018
...Huili Guo The control of translation is increasingly recognized as a major factor in determining protein levels in the cell. The ribosome — the cellular machine that mediates protein synthesis — is typically seen as a key, but invariant, player in this process. This is because translational control...
Articles
Translational control of synaptic plasticity
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1527–1530.
Published: 24 November 2010
... is modified by the frequency with which the synapses are stimulated. This modulation of synaptic strength, or synaptic plasticity, probably forms the cellular basis for learning and memory. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting...
Articles
Coping with stress: eIF2 kinases and translational control
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 7–11.
Published: 20 January 2006
... The Biochemical Society 2006 apoptosis eukaryotic initiation factor 2 (eIF2) protein kinase stress response translational control UV irradiation Phosphorylation of eIF2 reduces global protein synthesis concomitant with induced translation of selected mRNAs, such as those encoding the bZIP...
Articles
Engineered riboswitches control gene expression by small molecules
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 474–476.
Published: 01 June 2005
... that binding of the ligand tetracycline leads to a pseudoknot-like linkage within the aptamer structure, thereby inhibiting the initial steps of translation. A second translational control element was designed by combining a theophylline aptamer with a communication module for which a 1 nt slipping mechanism...
Articles
Sucrose-induced translational repression of plant bZIP-type transcription factors
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 272–275.
Published: 01 February 2005
... factors. Arabidopsis homologues of ATB2 / AtbZIP11 , which harbour the conserved uORF, also show SIRT. Therefore, SIRT emerges as a general sucrose translational control mechanism of a group of transcription factors. SIRT might be part of a sucrose-specific signalling pathway, controlling expression...
Articles
Choice of a start codon in a single transcript determines DNA ligase 1 isoform production and intracellular targeting in Arabidopsis thaliana
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (4): 614–616.
Published: 01 August 2004
... is only targeted to the mitochondria. This result raises intriguing questions on the translational control mechanisms that regulate how the protein products of a single transcript are targeted to more than one cellular compartment. 1 To whom correspondence should be addressed (email...