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Keywords: tryptophanyl-tRNA synthetase
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Biochem Soc Trans (2024) 52 (3): 1149–1158.
Published: 30 May 2024
... of Trp causes a reduction in extracellular Trp and initiates immune suppression. Recent studies demonstrate that both IDO1 and tryptophanyl-tRNA synthetase (TrpRS), whose expression levels are up-regulated by IFN-γ, play a pivotal role in high-affinity Trp uptake into human cells. Furthermore...